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Hydrocodone
Allay, Anexsia, Azdone, Bancap, Co-gesic, Codamine, Duradyne Dhc, Flowtuss, Hy-phen, Hycodan, Hycofenix, Hysingla, Lorcet-hd, Lortab, Norcet, Norco, Obredon, Reprexain, Rezira, Tycolet, Vicodin, Vicoprin, Vicoprofen, Vituz, Xtrelus, Zutripro, Zydone, Zyfrel (hydrocodone) is a small molecule pharmaceutical. Hydrocodone was first approved as Vicodin on 1982-01-01. It is used to treat cough, obstructive lung diseases, and postoperative pain in the USA. The pharmaceutical is active against mu-type opioid receptor. In addition, it is known to target kappa-type opioid receptor.
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Top Prescription Drugs
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
respiratory tract diseasesD012140
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Hysingla (generic drugs available since 1983-03-03, discontinued: Vantrela, Zohydro)
Combinations
Hycodan (generic drugs available since 1983-03-03, discontinued: Allay, Anexsia, Azdone, Bancap, Co-gesic, Codamine, Duradyne dhc, Flowtuss, Hy-phen, Hycofenix, Hydropane, Lorcet-hd, Lortab, Norcet, Norco, Obredon, Reprexain, Rezira, Tussigon, Tycolet, Vicodin, Vicoprin, Vicoprofen, Vituz, Xtrelus, Zutripro, Zydone, Zyfrel)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Chlorpheniramine maleate
+
Hydrocodone bitartrate
Tradename
Company
Number
Date
Products
VITUZPersion PharmaceuticalsN-204307 DISCN2013-02-20
1 products, RLD
Hide discontinued
Chlorpheniramine maleate
+
Hydrocodone bitartrate
+
Pseudoephedrine hydrochloride
Tradename
Company
Number
Date
Products
ZUTRIPROPersion PharmaceuticalsN-022439 DISCN2011-06-08
1 products, RLD
Hide discontinued
Guaifenesin
+
Hydrocodone bitartrate
Tradename
Company
Number
Date
Products
FLOWTUSSChartwell PharmaceuticalsN-022424 DISCN2015-05-14
1 products
XTRELUSECI PharmaceuticalsN-208085 DISCN2018-04-25
1 products, RLD
OBREDONSovereign PharmaceuticalsN-205474 DISCN2014-11-14
1 products, RLD
Hide discontinued
Guaifenesin
+
Hydrocodone bitartrate
+
Pseudoephedrine hydrochloride
Tradename
Company
Number
Date
Products
HYCOFENIXChartwell PharmaceuticalsN-022279 DISCN2015-05-14
1 products, RLD
Hide discontinued
Homatropine methylbromide
+
Hydrocodone bitartrate
Tradename
Company
Number
Date
Products
HYCODANGenus LifesciencesN-005213 RX1988-07-26
2 products, RLD
Hydrocodone bitartrate
Tradename
Company
Number
Date
Products
HYSINGLA ERPurdue PharmaN-206627 RX2014-11-20
7 products, RLD
Show 2 discontinued
Hydrocodone bitartrate
+
Ibuprofen
Tradename
Company
Number
Date
Products
VICOPROFENAbbVieN-020716 DISCN1997-09-23
1 products, RLD
Hide discontinued
Hydrocodone bitartrate
+
Pseudoephedrine hydrochloride
Tradename
Company
Number
Date
Products
REZIRAPersion PharmaceuticalsN-022442 DISCN2011-06-08
1 products, RLD
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
hycodanNew Drug Application2021-12-29
hydrocodone bitartrate and acetaminophenANDA2023-06-12
hysingla erNew Drug Application2021-03-01
lortabANDA2022-01-28
norcoANDA2023-03-20
obredonNew Drug Application2021-09-30
reprexainANDA2009-10-27
vicoprofenNew Drug Application2011-08-12
zohydroNew Drug Application2015-02-25
zydoneANDA2010-07-13
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
coughHP_0012735D003371R05
obstructive lung diseasesHP_0006536D008173
postoperative painD010149G89.18
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Guaifenesin / Hydrocodone Bitartrate, Obredon, Sovereign Pharms
95499072035-11-13DS, DPU-2023
98084312035-11-13DS, DPU-2023
101053242035-11-13DS, DPU-2023
Hydrocodone Bitartrate, Zohydro Er, Recro Gainesville
91320962034-09-12DP
94521632034-09-12U-55
94864512034-09-12U-55
97136112034-09-12DPU-55
100925592034-09-12U-55
92657602033-07-25U-1810
93269822033-07-25U-1810
93332012033-07-25U-1810
93394992033-07-25U-1810
94212002033-07-25U-1810
94336192033-07-25U-1810
96102862033-07-25U-1810
100289462033-07-25U-1810
103221202033-07-25DP
104563932033-07-25U-1810
107225112033-07-25U-1810
Hydrocodone Bitartrate, Hysingla Er, Purdue Pharma Lp
88087402031-12-21DPU-1556
95727792031-12-21DP
97507032031-12-21DP
98615842031-12-21DP
98728372031-12-21DP
90848162027-08-24DP
90956142027-08-24U-1556
90956152027-08-24DP
94864122027-08-24DP
94864132027-08-24DP
94923892027-08-24DP
94923902027-08-24U-1556
94923912027-08-24U-1556
95453802027-08-24U-1556
97639332027-08-24DP
97704162027-08-24DP
97758092027-08-24DP
113049082027-08-24DP
113049092027-08-24U-1556
83090602023-11-20DPU-1556
101305912023-11-20DPU-1819
96756102023-06-16DP
103691092023-06-16DP
Hydrocodone Bitartrate, Vantrela Er, Teva Branded Pharm
84450182029-07-31DP
92161762027-09-13DP
95728032027-09-13DP
ATC Codes
R: Respiratory system drugs
R05: Cough and cold preparations
R05D: Cough suppressants, excl. combinations with expectorants
R05DA: Opium alkaloids and derivatives, cough suppressants
R05DA03: Hydrocodone
HCPCS
No data
Clinical
Clinical Trials
129 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PainD010146EFO_0003843R524766225
Postoperative painD010149G89.182269221
Chronic painD059350HP_0012532325
Acute painD059787R522114
NauseaD009325HP_0002018R11.0213
Postoperative nausea and vomitingD020250EFO_0004888112
Rotator cuff injuriesD000070636M75.1112
Pain managementD05940822
ConstipationD003248HP_0002019K59.022
ToothacheD014098K08.89112
Show 29 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Low back painD017116HP_0003419M54.51416
OsteoarthritisD010003EFO_0002506M15-M19112
Anterior cruciate ligament injuriesD000070598122
Shoulder painD020069HP_0030834M25.51112
Head and neck neoplasmsD006258112
VomitingD014839HP_0002013R11.122
Postoperative complicationsD01118311
Tibial meniscus injuriesD00007060011
Multiple myelomaD009101C90.011
LymphomaD008223C85.911
Show 8 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Musculoskeletal painD059352112
Corneal injuriesD065306HP_000055911
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients77
Drug interactionsD004347112
Opioid-related disordersD009293EFO_0005611F1122
Intervertebral disc degenerationD055959HP_000841911
SpondylolisthesisD013168EFO_0007493M43.111
Ankle fracturesD064386S82.511
StomatitisD013280EFO_1001904K12.111
Substance-related disordersD019966EFO_0003890F1311
Hepatic insufficiencyD04855011
Renal insufficiencyD051437HP_0000083N1911
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hip fracturesD006620EFO_0003964S72.0011
AnesthesiaD00075811
Breast neoplasmsD001943EFO_0003869C5011
ThyroidectomyD01396511
Soft tissue injuriesD01769511
LacerationsD02212511
MethodsD00872211
Tooth migrationD01408511
DysmenorrheaD004412HP_0100607N94.611
SleepD012890GO_003043111
Show 2 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameHYDROCODONE
INNhydrocodone
Description
Hydrocodone is a morphinane-like compound that is a semi-synthetic opioid synthesized from codeine. It has a role as a mu-opioid receptor agonist, an opioid analgesic and an antitussive. It is an organic heteropentacyclic compound and a morphinane-like compound. It derives from a hydride of a morphinan.
Classification
Small molecule
Drug class
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COc1ccc2c3c1O[C@H]1C(=O)CC[C@H]4[C@@H](C2)N(C)CC[C@]314
Identifiers
PDB
CAS-ID125-29-1
RxCUI5489
ChEMBL IDCHEMBL1457
ChEBI ID5779
PubChem CID5284569
DrugBankDB00956
UNII ID6YKS4Y3WQ7 (ChemIDplus, GSRS)
Target
Agency Approved
OPRM1
OPRM1
Organism
Homo sapiens
Gene name
OPRM1
Gene synonyms
MOR1
NCBI Gene ID
Protein name
mu-type opioid receptor
Protein synonyms
hMOP, MOP, Mu opiate receptor, Mu opioid receptor, mu opioid receptor hMOR-1a
Uniprot ID
Mouse ortholog
Oprm1 (18390)
mu-type opioid receptor (P42866)
Alternate
OPRK1
OPRK1
Organism
Homo sapiens
Gene name
OPRK1
Gene synonyms
OPRK
NCBI Gene ID
Protein name
kappa-type opioid receptor
Protein synonyms
kappa opioid receptor, Opiate receptor, kappa-1
Uniprot ID
Mouse ortholog
Oprk1 (18387)
kappa-type opioid receptor (P33534)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 15,805 documents
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Safety
Black-box Warning
Black-box warning for: Hycodan, Hydrocodone bitartrate and acetaminophen, Hysingla er, Lortab, Norco, Obredon, Zohydro
Adverse Events
Top Adverse Reactions
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83,315 adverse events reported
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