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Guanadrel
Hylorel (guanadrel) is a small molecule pharmaceutical. Guanadrel was first approved as Hylorel on 1982-12-29. It is used to treat hypertension in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
cardiovascular diseasesD002318
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Guanadrel sulfate
Tradename
Company
Number
Date
Products
HYLORELPharmacia & UpjohnN-018104 DISCN1982-12-29
2 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
hypertensionEFO_0000537D006973I10
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
3 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Non-alcoholic fatty liver diseaseD065626EFO_0003095K75.8111
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Multiple sclerosisD009103EFO_0003885G3511
Relapsing-remitting multiple sclerosisD020529EFO_000392911
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Bone neoplasmsD001859EFO_0003820D1611
Neoplasm metastasisD009362EFO_000970811
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameGUANADREL
INNguanadrel
Description
Guanadrel is a spiroketal resulting from the formal condensation of the keto group of cyclohexanone with the hydroxy groups of 1-(2,3-dihydroxypropyl)guanidine. A postganglionic adrenergic blocking agent formerly used (generally as the sulfate salt) for the management of hypertension, it has been largely superseded by other drugs less likely to cause orthostatic hypotension (dizzy spells on standing up or stretching). It has a role as an antihypertensive agent and an adrenergic antagonist. It is a member of guanidines and a spiroketal. It is a conjugate base of a guanadrel(1+).
Classification
Small molecule
Drug classantihypertensives (guanidine deriviatives)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
N=C(N)NCC1COC2(CCCCC2)O1
Identifiers
PDB
CAS-ID40580-59-4
RxCUI26296
ChEMBL IDCHEMBL1037
ChEBI ID5555
PubChem CID38521
DrugBankDB00226
UNII ID765C9332T4 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 44 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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19 adverse events reported
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