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Gemfibrozil
Lopid (gemfibrozil) is a small molecule pharmaceutical. Gemfibrozil was first approved as Lopid on 1982-01-01. It is used to treat coronary artery disease, hypercholesterolemia, hyperlipoproteinemias, and hypertriglyceridemia in the USA. The pharmaceutical is active against peroxisome proliferator-activated receptor alpha. In addition, it is known to target solute carrier organic anion transporter family member 2B1, solute carrier organic anion transporter family member 1B1, solute carrier organic anion transporter family member 1B3, and albumin.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
cardiovascular diseasesD002318
nutritional and metabolic diseasesD009750
Trade Name
FDA
EMA
Lopid (generic drugs available since 1993-09-27)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Gemfibrozil
Tradename
Company
Number
Date
Products
LOPIDPfizerN-018422 RX1986-11-20
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
gemfibrozilANDA2023-06-19
lopidNew Drug Application2020-12-17
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
coronary artery disease—D003324I25.1
hypercholesterolemiaHP_0003124D006937—
hyperlipoproteinemias—D006951—
hypertriglyceridemiaEFO_0004211D015228—
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C10: Lipid modifying agents
— C10A: Lipid modifying agents, plain
— C10AB: Fibrates, lipid modifying drugs, plain
— C10AB04: Gemfibrozil
HCPCS
Code
Description
G9507
Documentation that the patient is on a statin medication or has documentation of a valid contraindication or exception to statin medications; contraindications/exceptions that can be defined by diagnosis codes include pregnancy during the measurement period, active liver disease, rhabdomyolysis, end stage renal disease on dialysis and heart failure; provider documented contraindications/exceptions include breastfeeding during the measurement period, woman of child-bearing age not actively taking birth control, allergy to statin, drug interaction (hiv protease inhibitors, nefazodone, cyclosporine, gemfibrozil, and danazol) and intolerance (with supporting documentation of trying a statin at least once within the last 5 years or diagnosis codes for myostitis or toxic myopathy related to drugs)
Clinical
Clinical Trials
28 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
InfectionsD007239EFO_0000544———13619
Helicobacter pyloriD016480NCBITaxon_210B96.81———213
GastritisD005756EFO_0000217K29.7———213
Stomach neoplasmsD013274EFO_0003897C16———2—2
Duodenal ulcerD004381EFO_0004607K26———1—1
Peptic ulcerD010437HP_0004398K27———1—1
DyspepsiaD004415EFO_0008533K30———1—1
Stomach ulcerD013276K25———1—1
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameGEMFIBROZIL
INNgemfibrozil
Description
Gemfibrozil is an aromatic ether. It has a role as an antilipemic drug. It is functionally related to a valeric acid.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cc1ccc(C)c(OCCCC(C)(C)C(=O)O)c1
Identifiers
PDB7QFE
CAS-ID25812-30-0
RxCUI4719
ChEMBL IDCHEMBL457
ChEBI ID5296
PubChem CID3463
DrugBankDB01241
UNII IDQ8X02027X3 (ChemIDplus, GSRS)
Target
Agency Approved
PPARA
PPARA
Organism
Homo sapiens
Gene name
PPARA
Gene synonyms
NR1C1, PPAR
NCBI Gene ID
5465
Protein name
peroxisome proliferator-activated receptor alpha
Protein synonyms
Nuclear receptor subfamily 1 group C member 1, peroxisome proliferative activated receptor, alpha
Uniprot ID
Q9Y3N1
Mouse ortholog
Ppara (19013)
peroxisome proliferator-activated receptor alpha (P23204)
Alternate
SLCO2B1
SLCO2B1
SLCO1B1
SLCO1B1
SLCO1B3
SLCO1B3
ALB
ALB
Organism
Homo sapiens
Gene name
SLCO2B1
Gene synonyms
KIAA0880, OATP2B1, OATPB, SLC21A9
NCBI Gene ID
11309
Protein name
solute carrier organic anion transporter family member 2B1
Protein synonyms
OATP-B, OATP-RP2, OATP2B1, OATPRP2, Organic anion transporter B, Organic anion transporter polypeptide-related protein 2, Organic anion transporting polypeptide 2B1, solute carrier family 21 (organic anion transporter), member 9, Solute carrier family 21 member 9
Uniprot ID
O94956
Mouse ortholog
Slco2b1 (101488)
solute carrier organic anion transporter family member 2B1 (Q8BXB6)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 5,252 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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30 adverse events reported
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