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Fosinopril
Monopril, Monopril-hct (fosinopril) is a small molecule pharmaceutical. Fosinopril was first approved as Monopril on 1991-05-16. It is used to treat diabetic nephropathies, heart failure, hypertension, and left ventricular dysfunction in the USA. The pharmaceutical is active against angiotensin-converting enzyme.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
urogenital diseasesD000091642
cardiovascular diseasesD002318
endocrine system diseasesD004700
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Fosinopril sodium
Tradename
Company
Number
Date
Products
MONOPRILBristol Myers SquibbN-019915 DISCN1991-05-16
3 products, RLD
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Fosinopril sodium
+
Hydrochlorothiazide
Tradename
Company
Number
Date
Products
MONOPRIL-HCTBristol Myers SquibbN-020286 DISCN1994-11-30
2 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
fosinopril sodiumANDA2023-06-15
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
diabetic nephropathiesEFO_0000401D003928
heart failureEFO_0003144D006333I50
hypertensionEFO_0000537D006973I10
left ventricular dysfunctionD018487
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
C09: Agents acting on the renin-angiotensin system
C09A: Ace inhibitors, plain
C09AA: Ace inhibitors, plain
C09AA09: Fosinopril
C09B: Ace inhibitors, combinations
C09BA: Ace inhibitors and diuretics
C09BA09: Fosinopril and diuretics
HCPCS
No data
Clinical
Clinical Trials
29 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hiv infectionsD015658EFO_0000764B207442623
Cytomegalovirus retinitisD017726EFO_10013022421413
Cytomegalovirus infectionsD003586EFO_0001062B25213
HypocalcemiaD006996HP_0002901E83.5111
Hematologic diseasesD006402EFO_0005803D75.911
Herpes zosterD006562EFO_0006510B0211
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Herpes simplexD006561B001124
Acquired immunodeficiency syndromeD000163EFO_0000765B2011
Papillomavirus infectionsD03036111
Gastrointestinal diseasesD00576711
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Graft vs host diseaseD006086D89.8111
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Brain diseasesD001927HP_0001298G93.4011
RadiculopathyD011843M54.111
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Myelodysplastic syndromesD009190D4611
Myeloid leukemia acuteD015470C92.011
Non-hodgkin lymphomaD008228C85.911
Extranodal nk-t-cell lymphomaD054391C86.011
Essential thrombocythemiaD013920D47.311
Polycythemia veraD011087D4511
Primary myelofibrosisD055728D47.411
Multiple myelomaD009101C90.011
Precursor cell lymphoblastic leukemia-lymphomaD054198C91.011
B-cell chronic lymphocytic leukemiaD015451C91.111
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameFOSINOPRIL
INNfosinopril
Description
Fosinopril is a phosphinate ester-containing N-acyl derivative of (4S)-cyclohexyl-L-proline. It is used for the treatment of hypertension and heart failure. A pro-drug, it is hydrolysed in vivo to the corresponding phosphininc acid, fosinoprilat, which is the active metabolite. It has a role as an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor, a prodrug and an antihypertensive agent. It is a phosphinic ester and a L-proline derivative. It is functionally related to a fosinoprilat. It is a conjugate acid of a fosinopril(1-).
Classification
Small molecule
Drug classphosphoro-derivatives; antihypertensives (ACE inhibitors)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCC(=O)O[C@@H](O[P@](=O)(CCCCc1ccccc1)CC(=O)N1C[C@H](C2CCCCC2)C[C@H]1C(=O)O)C(C)C
Identifiers
PDB
CAS-ID1217600-34-4
RxCUI
ChEMBL IDCHEMBL3039598
ChEBI ID
PubChem CID55891
DrugBankDB00492
UNII IDR43D2573WO (ChemIDplus, GSRS)
Target
Agency Approved
ACE
ACE
Organism
Homo sapiens
Gene name
ACE
Gene synonyms
DCP, DCP1
NCBI Gene ID
Protein name
angiotensin-converting enzyme
Protein synonyms
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1, carboxycathepsin, CD143, CD143 antigen, dipeptidyl carboxypeptidase 1, Dipeptidyl carboxypeptidase I, Kininase II, peptidase P
Uniprot ID
Mouse ortholog
Ace (11421)
angiotensin-converting enzyme (P09470)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
Black-box warning for: Fosinopril sodium
Adverse Events
Top Adverse Reactions
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1,889 adverse events reported
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