Fluocinonide
Lidex, Vanos (fluocinonide) is a small molecule pharmaceutical. Fluocinonide was first approved as Lidex on 1982-01-01. It is used to treat facial dermatoses, foot dermatoses, hand dermatoses, inflammation, and leg dermatoses amongst others in the USA. The pharmaceutical is active against glucocorticoid receptor.
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Commercial
Trade Name
FDA
EMA
Lidex, Vanos (generic drugs available since 1987-06-10)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| fluocinonide cream | ANDA | 2023-06-08 |
| vanos | New Drug Application | 2017-05-01 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| facial dermatoses | — | D005148 | — |
| foot dermatoses | — | D005533 | — |
| hand dermatoses | — | D006229 | — |
| inflammation | MP_0001845 | D007249 | — |
| leg dermatoses | — | D007868 | — |
| pruritus | HP_0000989 | D011537 | L29 |
| scalp dermatoses | — | D012536 | — |
Agency Specific
FDA
EMA
No data
ATC Codes
C: Cardiovascular system drugs
— C05: Vasoprotectives
— C05A: Agents for treatment of hemorrhoids and anal fissures for topical use
— C05AA: Corticosteroids, topical for treatment of hemorrhoids and anal fissures
— C05AA11: Fluocinonide
D: Dermatologicals
— D07: Corticosteroids, dermatological preparations
— D07A: Corticosteroid dermatological preparations, plain
— D07AC: Corticosteroids, potent (group iii)
— D07AC08: Fluocinonide
— D07C: Corticosteroids, combinations with antibiotics
— D07CC: Corticosteroids, potent, combinations with antibiotics
— D07CC05: Fluocinonide and antibiotics
HCPCS
No data
Clinical
Clinical Trials
55 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Macular edema | D008269 | — | 4 | 5 | 4 | 1 | 12 | ||
| Uveitis | D014605 | EFO_1001231 | H20.9 | 1 | — | 1 | 3 | 3 | 8 |
| Melanosis | D008548 | EFO_0003963 | L81.1 | — | 1 | 1 | 4 | — | 5 |
| Posterior uveitis | D015866 | EFO_1001119 | — | 1 | 2 | 1 | 2 | 5 | |
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | — | 1 | — | 2 | — | 3 |
| Hypersensitivity | D006967 | EFO_0003785 | T78.40 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Intermediate uveitis | D015867 | EFO_1000986 | — | — | 1 | — | 1 | 2 | |
| Otitis externa | D010032 | EFO_0009560 | H60 | — | — | 1 | — | — | 1 |
| Anterior uveitis | D014606 | EFO_1000811 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | 1 | 3 | — | — | — | 4 |
| Retinal vein occlusion | D012170 | EFO_1001157 | H34.81 | 1 | 1 | — | — | 1 | 3 |
| Exanthema | D005076 | R21 | — | 1 | — | — | — | 1 | |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Psoriasis | D011565 | EFO_0000676 | L40 | 2 | — | — | — | — | 2 |
| Choroidal neovascularization | D020256 | 1 | — | — | — | — | 1 | ||
| Glaucoma | D005901 | EFO_0000516 | H40 | 1 | — | — | — | — | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | FLUOCINONIDE |
| INN | fluocinonide |
| Description | Fluocinonide is an organic molecular entity. |
| Classification | Small molecule |
| Drug class | topical steroids (acetal derivatives) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CC(=O)OCC(=O)[C@@]12OC(C)(C)O[C@@H]1C[C@H]1[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]12C |
Identifiers
| PDB | — |
| CAS-ID | 356-12-7 |
| RxCUI | 4462 |
| ChEMBL ID | CHEMBL1501 |
| ChEBI ID | — |
| PubChem CID | 9642 |
| DrugBank | DB01047 |
| UNII ID | 2W4A77YPAN (ChemIDplus, GSRS) |
Target
Agency Approved
NR3C1
NR3C1
Organism
Homo sapiens
Gene name
NR3C1
Gene synonyms
GRL
NCBI Gene ID
Protein name
glucocorticoid receptor
Protein synonyms
Nuclear receptor subfamily 3 group C member 1, nuclear receptor subfamily 3 group C member 1 variant hGR-B(54), nuclear receptor subfamily 3 group C member 1 variant hGR-B(77), nuclear receptor subfamily 3 group C member 1 variant hGR-B(93), nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Uniprot ID
Mouse ortholog
Nr3c1 (14815)
glucocorticoid receptor (Q61629)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 721 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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2,251 adverse events reported
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