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Repatha(evolocumab)
Repatha (evolocumab) is an antibody pharmaceutical. Evolocumab was first approved as Repatha on 2015-07-17. It is used to treat atherosclerosis and hypercholesterolemia in the USA. It has been approved in Europe to treat dyslipidemias and hypercholesterolemia. The pharmaceutical is active against proprotein convertase subtilisin/kexin type 9.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
cardiovascular diseasesD002318
nutritional and metabolic diseasesD009750
Trade Name
FDA
EMA
Repatha
Drug Products
FDA
EMA
Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Evolocumab
Tradename
Proper name
Company
Number
Date
Products
RepathaevolocumabAmgenN-125522 RX2015-08-27
3 products
Labels
FDA
EMA
Brand Name
Status
Last Update
repathaBiologic Licensing Application2023-06-07
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
atherosclerosisEFO_0003914D050197I25.1
hypercholesterolemiaHP_0003124D006937
Agency Specific
FDA
EMA
Expiration
Code
evolocumab, Repatha, Amgen Inc.
2028-09-24Orphan excl.
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
C10: Lipid modifying agents
C10A: Lipid modifying agents, plain
C10AX: Other lipid modifying agents in atc
C10AX13: Evolocumab
HCPCS
No data
Clinical
Clinical Trials
110 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypercholesterolemiaD006937HP_00031243112218
HyperlipidemiasD006949EFO_0003774E78.52310217
Hyperlipoproteinemia type iiD006938EFO_0004911E78.00452110
Acute coronary syndromeD054058EFO_000567221238
DyslipidemiasD050171HP_00031195128
Coronary artery diseaseD003324I25.111327
Type 2 diabetes mellitusD003924EFO_0001360E111146
St elevation myocardial infarctionD000072657134
AtherosclerosisD050197EFO_0003914I25.11214
Cardiovascular diseasesD002318EFO_0000319I98213
Show 17 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Coronary diseaseD003327112
Hiv infectionsD015658EFO_0000764B2011
Covid-19D000086382U07.111
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Non-small-cell lung carcinomaD002289111
Hereditary spastic paraplegiaD015419EFO_0000529G11.4111
SepsisD018805A41.911
Heart failureD006333EFO_0003144I5011
HivD006678O98.711
Lung neoplasmsD008175C34.9011
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PharmacokineticsD01059911
Healthy volunteers/patients11
GlioblastomaD005909EFO_000051511
GliomaD005910EFO_000052011
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
InflammationD00724911
Genetic polymorphismD01111011
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameEVOLOCUMAB
INNevolocumab
Description
Evolocumab (human mab)
Classification
Antibody
Drug classmonoclonal antibodies
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Identifiers
PDB
CAS-ID1256937-27-5
RxCUI1665684
ChEMBL IDCHEMBL2364655
ChEBI ID
PubChem CID
DrugBankDB09303
UNII IDLKC0U3A8NJ (ChemIDplus, GSRS)
Target
Agency Approved
PCSK9
PCSK9
Organism
Homo sapiens
Gene name
PCSK9
Gene synonyms
NARC1
NCBI Gene ID
Protein name
proprotein convertase subtilisin/kexin type 9
Protein synonyms
convertase subtilisin/kexin type 9 preproprotein, NARC-1, neural apoptosis regulated convertase 1, Neural apoptosis-regulated convertase 1, PC9, Proprotein convertase 9, Subtilisin/kexin-like protease PC9
Uniprot ID
Mouse ortholog
Pcsk9 (100102)
proprotein convertase subtilisin/kexin type 9 (Q8CFT6)
Alternate
No data
Variants
Clinical Variant
No data
Financial
Repatha - Amgen
$
£
Mock data
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 3,150 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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43,206 adverse events reported
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