Ethotoin
Peganone (ethotoin) is a small molecule pharmaceutical. Ethotoin was first approved as Peganone on 1982-01-01. It is used to treat complex partial epilepsy, epilepsy, seizures, and tonic-clonic epilepsy in the USA.
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Ethotoin
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| PEGANONE | Recordati | N-010841 DISCN | 1982-01-01 | 2 products |
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Indications
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Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| complex partial epilepsy | EFO_1000877 | D017029 | — |
| epilepsy | EFO_0000474 | D004827 | G40.9 |
| seizures | HP_0007359 | D012640 | G40.4 |
| tonic-clonic epilepsy | EFO_0007262 | D004830 | — |
Agency Specific
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Clinical
Clinical Trials
10 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Epilepsy | D004827 | EFO_0000474 | G40.9 | — | — | 1 | — | 1 | 2 |
| Irritable bowel syndrome | D043183 | EFO_0000555 | K58 | — | 1 | 1 | — | — | 2 |
| Seizures | D012640 | G40.4 | — | — | 1 | — | — | 1 | |
| Absence epilepsy | D004832 | G40.A | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neuralgia | D009437 | EFO_0009430 | — | 2 | — | — | — | 2 | |
| Complex regional pain syndromes | D020918 | EFO_1001998 | — | 1 | — | — | — | 1 | |
| Pain | D010146 | EFO_0003843 | R52 | — | 1 | — | — | — | 1 |
| Neoplasms | D009369 | C80 | — | 1 | — | — | — | 1 | |
| Peripheral nervous system diseases | D010523 | G64 | — | 1 | — | — | — | 1 | |
| Migraine disorders | D008881 | EFO_0003821 | G43 | 1 | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Treatment-resistant depressive disorder | D061218 | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | ETHOTOIN |
| INN | ethotoin |
| Description | Ethotoin is an imidazolidine-2,4-dione that is hydantoin substituted by ethyl and phenyl at positions 3 and 5, respectively. An antiepileptic, it is less toxic than phenytoin but also less effective. It has a role as an anticonvulsant. |
| Classification | Small molecule |
| Drug class | antiepileptics (hydantoin derivatives) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CCN1C(=O)NC(c2ccccc2)C1=O |
Identifiers
| PDB | — |
| CAS-ID | 86-35-1 |
| RxCUI | 4136 |
| ChEMBL ID | CHEMBL1095 |
| ChEBI ID | 4888 |
| PubChem CID | 3292 |
| DrugBank | DB00754 |
| UNII ID | 46QG38NC4U (ChemIDplus, GSRS) |
Target
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Safety
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985 adverse events reported
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