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Enflurane
Ethrane (enflurane) is a small molecule pharmaceutical. Enflurane was first approved as Ethrane on 1982-01-01. It is used to treat status asthmaticus and ventricular premature complexes in the USA.
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Therapeutic Areas
Therapeutic Area
MeSH
respiratory tract diseasesD012140
cardiovascular diseasesD002318
immune system diseasesD007154
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Enflurane
Tradename
Company
Number
Date
Products
ETHRANEBaxterN-017087 DISCN1982-01-01
1 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
status asthmaticus—D013224—
ventricular premature complexes—D018879I49.3
Agency Specific
FDA
EMA
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Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N01: Anesthetics
— N01A: Anesthetics, general
— N01AB: Halogenated hydrocarbons, general anesthetics
— N01AB04: Enflurane
HCPCS
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Clinical
Clinical Trials
1 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
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Indications Phases 1
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Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameENFLURANE
INNenflurane
Description
Enflurane is an ether in which the oxygen atom is connected to 2-chloro-1,1,2-trifluoroethyl and difluoromethyl groups. It has a role as an anaesthetic. It is an organofluorine compound, an organochlorine compound and an ether. It is functionally related to a methoxyethane.
Classification
Small molecule
Drug classgeneral inhalation anesthetics (halogenated alkane derivatives)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
FC(F)OC(F)(F)C(F)Cl
Identifiers
PDB—
CAS-ID13838-16-9
RxCUI3920
ChEMBL IDCHEMBL1257
ChEBI ID4792
PubChem CID3226
DrugBankDB00228
UNII ID91I69L5AY5 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
Identifier
Target mutation
Effect
Evaluation
Status
VCV000575733CACNA1S, 520C>T, Arg174Trpdrug response2021-03-241A
VCV000017626CACNA1S, 3257G>A, Arg1086Hisdrug response2021-03-241A
VCV000012984RYR1, 14545G>A, Val4849Iledrug response2021-03-241A
VCV000012972RYR1, 7373G>A, Arg2458Hisdrug response2021-03-241A
Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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46 adverse events reported
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