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Sumatriptan
Imitrex, Onzetra, Tosymra, Treximet, Zembrace (sumatriptan) is a small molecule pharmaceutical. Sumatriptan was first approved as Imitrex on 1992-12-28. It is used to treat cluster headache and migraine disorders in the USA. The pharmaceutical is active against 5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine receptor 1D. In addition, it is known to target 5-hydroxytryptamine receptor 1F, 5-hydroxytryptamine receptor 6, 5-hydroxytryptamine receptor 1A, 5-hydroxytryptamine receptor 7, 5-hydroxytryptamine receptor 5A, and 5-hydroxytryptamine receptor 1E.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
Trade Name
FDA
EMA
Imitrex, Imitrex statdose, Onzetra, Tosymra, Zembrace (generic drugs available since 2009-02-06, discontinued: Alsuma, Sumavel dosepro, Zecuity)
Combinations
Treximet (generic drugs available since 2009-02-06)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Naproxen sodium
+
Sumatriptan succinate
Tradename
Company
Number
Date
Products
TREXIMETCurrax PharmaceuticalsN-021926 RX2008-04-15
1 products, RLD, RS
Show 1 discontinued
Sumatriptan
Tradename
Company
Number
Date
Products
IMITREXGSKN-020626 RX1997-08-26
2 products, RLD, RS
TOSYMRAUpsher-Smith LaboratoriesN-210884 RX2019-01-25
1 products, RLD, RS
Show 1 discontinued
Sumatriptan succinate
Tradename
Company
Number
Date
Products
ONZETRA XSAILCurrax PharmaceuticalsN-206099 RX2016-01-27
1 products, RLD, RS
IMITREX STATDOSEGSKN-020080 RX1996-12-23
2 products, RLD, RS
IMITREXGSKN-020080 RX1992-12-28
1 products, RLD, RS
IMITREXGSKN-020132 RX1995-06-01
3 products, RLD
ZEMBRACE SYMTOUCHUpsher-Smith LaboratoriesN-208223 RX2016-01-28
1 products, RLD
Show 3 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
imitrexNew Drug Application2023-02-08
onzetra xsailNew Drug Application2021-07-13
sumatriptan succinateANDA2023-03-01
sumavel doseproNew Drug Application2014-02-07
tosymraNew Drug Application2021-09-02
treximetNew Drug Application2021-05-04
zembrace symtouchNew Drug Application2021-04-08
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
cluster headacheHP_0012199D003027G44.00
migraine disordersEFO_0003821D008881G43
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Sumatriptan Succinate, Zembrace Symtouch, Upsher Smith Labs
105375542036-01-29U-72
113642242036-01-29U-72
Sumatriptan Succinate, Onzetra Xsail, Currax
100766142034-10-20DP
104785742033-11-04U-2404
89786472030-12-06DP
96494562030-10-21DPU-1719, U-2010, U-2011
88992292030-08-18DP
85500732029-10-22DP
100766152029-07-30U-2010, U-2011, U-2404
107226672028-12-30DP
88757042028-04-07DPU-1809
103988592027-12-19DP
101241322027-03-06DPU-1719, U-2010, U-2011
115715312026-02-23U-1809
85905302025-09-15DPU-1809
91080152025-09-15DP
79756902025-08-18DPU-1809
91199322024-04-23DP
83278442023-10-03U-1809
80472022023-07-02DP
Sumatriptan Succinate, Zecuity, Teva Branded Pharm
93271142032-10-08DPU-1328
89835942030-11-19DPU-1328
83666002029-04-21U-1327
92721372027-09-07DP
79730582027-04-12U-1328
81557372027-04-12U-1328
84708532027-04-12U-1328
85972722027-04-12DP
94275782027-04-12DPU-1328
67450712023-02-21DP
Sumatriptan, Tosymra, Upsher Smith Labs
92112822031-07-19DPU-1719
96102802030-06-16DPU-1719
99747702030-06-16DPU-1719
106033052030-06-16DPU-1719
113379622030-06-16DPU-1719
82687912026-05-09DP
84406312026-05-09DPU-1719
92832802026-05-09DP
Sumatriptan Succinate, Alsuma, Meridian Medcl
78112542027-08-26DPU-1083
Sumatriptan Succinate, Sumavel Dosepro, Endo Ventures Ltd
77760072026-11-22DP
79013852026-07-31DP
82874892024-12-06DP
81187712023-08-10DP
82412432023-08-10DP
82679032023-03-18DP
Naproxen Sodium / Sumatriptan Succinate, Treximet, Currax
73321832025-10-02DPU-867, U-1719
ATC Codes
N: Nervous system drugs
— N02: Analgesics
— N02C: Antimigraine preparations
— N02CC: Selective serotonin (5ht1) agonists
— N02CC01: Sumatriptan
HCPCS
Code
Description
J3030
Injection, sumatriptan succinate, 6 mg (code may be used for medicare when drug administered under the direct supervision of a physician, not for use when drug is self administered)
Clinical
Clinical Trials
8 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Adrenocortical carcinomaD018268——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Pancreatic neoplasmsD010190EFO_0003860C25—2———2
Islet cell adenomaD007516EFO_0007331D13.7—2———2
NeoplasmsD009369C80—1———1
Brain neoplasmsD001932EFO_0003833C71—1———1
GlioblastomaD005909EFO_0000515—1———1
GliomaD005910EFO_0000520—1———1
AstrocytomaD001254EFO_0000271—1———1
OligodendrogliomaD009837EFO_0000631—1———1
Neoplasm metastasisD009362EFO_0009708—1———1
Zollinger-ellison syndromeD015043E16.4—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Colorectal neoplasmsD0151791————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameSUMATRIPTAN
INNsumatriptan
Description
Sumatriptan is a sulfonamide that consists of N,N-dimethyltryptamine bearing an additional (N-methylsulfamoyl)methyl substituent at position 5. Selective agonist for a vascular 5-HT1 receptor subtype (probably a member of the 5-HT1D family). Used (in the form of its succinate salt) for the acute treatment of migraine with or without aura in adults. It has a role as a serotonergic agonist and a vasoconstrictor agent. It is a sulfonamide and a member of tryptamines. It is functionally related to a N,N-dimethyltryptamine. It is a conjugate acid of a sumatriptan(1+).
Classification
Small molecule
Drug classantimigraine agents (5-HT1 receptor agonists); sumatriptan derivatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1
Identifiers
PDB—
CAS-ID103628-46-2
RxCUI37418
ChEMBL IDCHEMBL128
ChEBI ID10650
PubChem CID5358
DrugBankDB00669
UNII ID8R78F6L9VO (ChemIDplus, GSRS)
Target
Agency Approved
HTR1B
HTR1B
HTR1D
HTR1D
Organism
Homo sapiens
Gene name
HTR1B
Gene synonyms
HTR1DB
NCBI Gene ID
3351
Protein name
5-hydroxytryptamine receptor 1B
Protein synonyms
5-HT-1D-beta, 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled, S12, Serotonin 1D beta receptor, Serotonin receptor 1B
Uniprot ID
Q4VAY7
Mouse ortholog
Htr1b (15551)
5-hydroxytryptamine receptor 1B (P28334)
Alternate
HTR1F
HTR1F
HTR6
HTR6
HTR1A
HTR1A
HTR7
HTR7
HTR5A
HTR5A
HTR1E
HTR1E
Organism
Homo sapiens
Gene name
HTR1F
Gene synonyms
HTR1EL
NCBI Gene ID
3355
Protein name
5-hydroxytryptamine receptor 1F
Protein synonyms
5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled, Serotonin receptor 1F
Uniprot ID
P30939
Mouse ortholog
Htr1f (15557)
5-hydroxytryptamine receptor 1F (Q02284)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 4,592 documents
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Safety
Black-box Warning
Black-box warning for: Treximet
Adverse Events
Top Adverse Reactions
Mock data
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134 adverse events reported
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