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Sulfinpyrazone
Anturane (sulfinpyrazone) is a small molecule pharmaceutical. Sulfinpyrazone was first approved as Anturane on 1982-01-01. It is used to treat angina pectoris, coronary disease, gout, and myocardial infarction in the USA. The pharmaceutical is active against solute carrier family 22 member 12. In addition, it is known to target fMet-Leu-Phe receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
musculoskeletal diseasesD009140
cardiovascular diseasesD002318
hereditary congenital and neonatal diseases and abnormalitiesD009358
nutritional and metabolic diseasesD009750
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Sulfinpyrazone
Tradename
Company
Number
Date
Products
ANTURANENovartisN-011556 DISCN1982-01-01
2 products, RLD
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
angina pectorisEFO_0003913D000787I20
coronary disease—D003327—
goutEFO_0004274D006073M10
myocardial infarctionEFO_0000612D009203I21
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
M: Musculo-skeletal system drugs
— M04: Antigout preparations
— M04A: Antigout preparations
— M04AB: Preparations increasing uric acid excretion
— M04AB02: Sulfinpyrazone
HCPCS
No data
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameSULFINPYRAZONE
INNsulfinpyrazone
Description
Sulfinpyrazone is a sulfoxide and a member of pyrazolidines. It has a role as a uricosuric drug.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=C1C(CC[S+]([O-])c2ccccc2)C(=O)N(c2ccccc2)N1c1ccccc1
Identifiers
PDB—
CAS-ID57-96-5
RxCUI10205
ChEMBL IDCHEMBL832
ChEBI ID9342
PubChem CID5342
DrugBankDB01138
UNII IDV6OFU47K3W (ChemIDplus, GSRS)
Target
Agency Approved
SLC22A12
SLC22A12
Organism
Homo sapiens
Gene name
SLC22A12
Gene synonyms
OATL4, URAT1
NCBI Gene ID
116085
Protein name
solute carrier family 22 member 12
Protein synonyms
Organic anion transporter 4-like protein, Renal-specific transporter, RST, solute carrier family 22 (organic anion/cation transporter), member 12, solute carrier family 22 (organic anion/urate transporter), member 12, URAT1, Urate anion exchanger 1, urate anion transporter 1, urate transporter 1, Urate:anion antiporter SLC22A12
Uniprot ID
Q96S37
Mouse ortholog
—
—
Alternate
FPR1
FPR1
Organism
Homo sapiens
Gene name
FPR1
Gene synonyms
NCBI Gene ID
2357
Protein name
fMet-Leu-Phe receptor
Protein synonyms
fMLP receptor, FPR, N-formyl peptide receptor, N-formylpeptide chemoattractant receptor
Uniprot ID
Q9NS48
Mouse ortholog
Fpr1 (14293)
fMet-Leu-Phe receptor (Q3UV01)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 1,488 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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136 adverse events reported
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