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Sincalide
Kinevac (sincalide) is a protein pharmaceutical. Sincalide was first approved as Kinevac on 1982-01-01. It is known to target gastrin/cholecystokinin type B receptor and cholecystokinin receptor type A.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
Kinevac
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Sincalide
Tradename
Company
Number
Date
Products
KINEVACBracco DiagnosticsN-017697 RX1982-01-01
1 products, RLD, RS
SINCALIDEMAIA BiotechnologyN-210850 RX2022-11-22
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
kinevacNew Drug Application2018-12-01
sincalide New Drug Application2023-02-03
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Sincalide, Sincalide, Maia Pharms Inc
111100632038-04-20DPU-3481, U-3482, U-3483
113181002038-04-20DPU-3477, U-3478, U-3479, U-3480
ATC Codes
V: Various drug classes in atc
— V04: Diagnostic agents
— V04C: Other diagnostic agents in atc
— V04CC: Diagnostic agents for bile duct patency testing
— V04CC03: Sincalide
HCPCS
Code
Description
J2805
Injection, sincalide, 5 micrograms
Clinical
Clinical Trials
43 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
ColonoscopyD003113——14—5
Irritable bowel syndromeD043183EFO_0000555K581——113
ColicD003085HP_0011848R10.83—1—113
DiarrheaD003967HP_0002014R19.7——11—2
Colonic neoplasmsD003110C18———112
Relapsing-remitting multiple sclerosisD020529EFO_0003929———1—1
Chronic renal insufficiencyD051436N18———1—1
Colonic polypsD003111K63.5———1—1
Stomach neoplasmsD013274EFO_0003897C16———1—1
IleusD045823K56.7———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Colorectal neoplasmsD015179——1—34
Female infertilityD007247EFO_0008560N97——1——1
DyspepsiaD004415EFO_0008533K30——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Stomach diseasesD013272—1——12
Otitis mediaD010033EFO_0004992H66.9—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—3———14
Abdominal painD015746R10.91————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Capsule endoscopyD053704————11
PolypsD011127EFO_0000662————11
AdenomaD000236————11
Lactose intoleranceD007787E73————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameSINCALIDE
INNsincalide
Description
Sincalide is an oligopeptide.
Classification
Peptide
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Identifiers
PDB—
CAS-ID25126-32-3
RxCUI9800
ChEMBL IDCHEMBL1121
ChEBI ID—
PubChem CID9833444
DrugBankDB09142
UNII IDM03GIQ7Z6P (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CCKBR
CCKBR
CCKAR
CCKAR
Organism
Homo sapiens
Gene name
CCKBR
Gene synonyms
CCKRB
NCBI Gene ID
887
Protein name
gastrin/cholecystokinin type B receptor
Protein synonyms
CCK-B receptor, CCK2 receptor, CCK2-R, Cholecystokinin-2 receptor, gastrin receptor
Uniprot ID
P32239
Mouse ortholog
Cckbr (12426)
gastrin/cholecystokinin type B receptor (P56481)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 531 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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4,537 adverse events reported
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