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Reserpine
Cam-ap-es, Demi-regroton, Diupres, Diutensen-r, Dralserp, H.r, Hiserpia, Hydrap-es, Hydro-reserp, Hydro-serp, Hydromox, Hydropres, Hydroserpine (r), Metatensin, Naqua, Naquival, Rau-sed, Regroton, Renese-r, Salutensin, Salutensin-demi, Sandril, Ser-a-gen, Ser-ap-es, Serpalan, Serpanray, Serpasil, Serpasil-apresoline, Serpasil-esidrix, Serpate, Serpivite, Unipres (reserpine) is a small molecule pharmaceutical. Reserpine was first approved as Chlorothiazide w/ reserpine on 1982-01-01. It is used to treat dyskinesias, hypertension, and schizophrenia in the USA. The pharmaceutical is active against synaptic vesicular amine transporter. In addition, it is known to target chromaffin granule amine transporter.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
mental disordersD001523
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Chlorothiazide
+
Reserpine
Tradename
Company
Number
Date
Products
DIUPRES-250Merck KGaAN-011635 DISCN1987-08-26
1 products
DIUPRES-500Merck KGaAN-011635 DISCN1987-08-26
1 products
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Chlorthalidone
+
Reserpine
Tradename
Company
Number
Date
Products
REGROTONSanofiN-015103 DISCN1982-01-01
1 products
DEMI-REGROTONSanofiN-015103 DISCN1982-01-01
1 products
Hide discontinued
Hydralazine hydrochloride
+
Hydrochlorothiazide
+
Reserpine
Tradename
Company
Number
Date
Products
SER-AP-ESNovartisN-012193 DISCN1982-01-01
1 products
Hide discontinued
Hydralazine hydrochloride
+
Reserpine
Tradename
Company
Number
Date
Products
SERPASIL-APRESOLINENovartisN-009296 DISCN1982-01-01
2 products
Hide discontinued
Hydrochlorothiazide
+
Reserpine
Tradename
Company
Number
Date
Products
HYDROPRES 25Merck KGaAN-011958 DISCN1982-01-01
1 products
HYDROPRES 50Merck KGaAN-011958 DISCN1982-01-01
1 products
SERPASIL-ESIDRIX #1NovartisN-011878 DISCN1982-01-01
1 products
SERPASIL-ESIDRIX #2NovartisN-011878 DISCN1982-01-01
1 products
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Hydroflumethiazide
+
Reserpine
Tradename
Company
Number
Date
Products
SALUTENSINShireN-012359 DISCN1982-01-01
1 products
SALUTENSIN-DEMIShireN-012359 DISCN1982-01-01
1 products
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Methyclothiazide
+
Reserpine
Tradename
Company
Number
Date
Products
DIUTENSEN-RMedpointe Pharm HlcN-012708 DISCN1982-01-01
1 products
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Polythiazide
+
Reserpine
Tradename
Company
Number
Date
Products
RENESE-RMylanN-013636 DISCN1982-01-01
1 products
Hide discontinued
Quinethazone
+
Reserpine
Tradename
Company
Number
Date
Products
HYDROMOX RLederle LaboratoriesN-013927 DISCN1982-01-01
1 products
Hide discontinued
Reserpine
Tradename
Company
Number
Date
Products
HISERPIABowman PharmaceuticalsN-009631 DISCN1982-01-01
2 products
RAU-SEDBristol Myers SquibbN-009357 DISCN1982-01-01
4 products
RESERPINECM BundyN-009663 DISCN1982-01-01
2 products
RESERPINECycle PharmaceuticalsN-009859 DISCN1982-01-01
2 products
RESERPINEEveryLife Foundation for Rare DiseasesN-010441 DISCN1982-01-01
4 products
RESERPINEImpax LaboratoriesN-009627 DISCN1982-01-01
2 products
RESERPINETevaN-011185 DISCN1982-01-01
2 products
SERPALANLannettN-010124 DISCN1982-01-01
2 products
SANDRILEli LillyN-009376 DISCN1982-01-01
2 products
SANDRILEli LillyN-010012 DISCN1982-01-01
1 products
SERPASILNovartisN-009115 DISCN1982-01-01
4 products
SERPASILNovartisN-009434 DISCN1982-01-01
1 products
SERPANRAYPanray CorporationN-009391 DISCN1982-01-01
3 products
RESERPINESandozN-009838 DISCN1982-01-01
2 products, RLD
SERPATEBausch Health CompaniesN-009453 DISCN1982-01-01
2 products
RESERPINEBausch Health CompaniesN-009667 DISCN1982-01-01
2 products
SERPIVITEVitarine PharmaceuticalsN-009645 DISCN1982-01-01
1 products
Hide discontinued
Reserpine
+
Trichlormethiazide
Tradename
Company
Number
Date
Products
METATENSIN #2SanofiN-012972 DISCN1982-01-01
1 products
METATENSIN #4SanofiN-012972 DISCN1982-01-01
1 products
NAQUIVALMerck Sharp & DohmeN-012265 DISCN1982-01-01
1 products
Hide discontinued
Trichlormethiazide
Tradename
Company
Number
Date
Products
NAQUAMerck Sharp & DohmeN-012265 DISCN1982-01-01
2 products
Hide discontinued
Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
dyskinesiasD020820G24
hypertensionEFO_0000537D006973I10
schizophreniaEFO_0000692D012559F20
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
C02: Antihypertensives
C02A: Antiadrenergic agents, centrally acting
C02AA: Rauwolfia alkaloids, centrally acting antiadrenergic
C02AA02: Reserpine
C02AA52: Reserpine, combinations
C02L: Antihypertensives and diuretics in combination
C02LA: Rauwolfia alkaloids and diuretics in combination
C02LA01: Reserpine and diuretics
C02LA51: Reserpine and diuretics, combinations with other drugs
C02LA71: Reserpine and diuretics, combinations with psycholeptics
HCPCS
No data
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameRESERPINE
INNreserpine
Description
Reserpine is an alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. It has a role as an antihypertensive agent, a first generation antipsychotic, an adrenergic uptake inhibitor, an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor, an environmental contaminant, a xenobiotic and a plant metabolite. It is an alkaloid ester, a methyl ester and a yohimban alkaloid. It is functionally related to a reserpic acid.
Classification
Small molecule
Drug classtricyclic compounds; Rauwolfia alkaloid derivatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC
Identifiers
PDB
CAS-ID50-55-5
RxCUI9260
ChEMBL IDCHEMBL772
ChEBI ID28487
PubChem CID5770
DrugBankDB00206
UNII ID8B1QWR724A (ChemIDplus, GSRS)
Target
Agency Approved
SLC18A2
SLC18A2
Organism
Homo sapiens
Gene name
SLC18A2
Gene synonyms
SVMT, VMAT2
NCBI Gene ID
Protein name
synaptic vesicular amine transporter
Protein synonyms
monoamine neurotransmitter transporter, Monoamine transporter, solute carrier family 18 (vesicular monoamine transporter), member 2, Solute carrier family 18 member 2, synaptic vesicle amine transporter, brain, synaptic vesicle monoamine transporter, brain, VAT2, vesicle monoamine transporter type 2, vesicle monoamine/H+ antiporter, Vesicular amine transporter 2
Uniprot ID
Mouse ortholog
Slc18a2 (214084)
synaptic vesicular amine transporter (Q8CC55)
Alternate
SLC18A1
SLC18A1
Organism
Homo sapiens
Gene name
SLC18A1
Gene synonyms
VAT1, VMAT1
NCBI Gene ID
Protein name
chromaffin granule amine transporter
Protein synonyms
solute carrier family 18 (vesicular monoamine transporter), member 1, solute carrier family 18 (vesicular monoamine), member 1, Solute carrier family 18 member 1, VAT1, Vesicular amine transporter 1
Uniprot ID
Mouse ortholog
Slc18a1 (110877)
chromaffin granule amine transporter (Q8R090)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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