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Motegrity, Resolor(prucalopride)
Motegrity, Resolor (prucalopride) is a small molecule pharmaceutical. Prucalopride was first approved as Resolor on 2009-10-14. It is used to treat constipation in the USA. It has been approved in Europe to treat constipation. It is known to target 5-hydroxytryptamine receptor 4.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Motegrity
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Prucalopride succinate
Tradename
Company
Number
Date
Products
MOTEGRITYTakedaN-210166 RX2018-12-14
2 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
motegrityNew Drug Application2021-03-22
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
constipationHP_0002019D003248K59.0
Agency Specific
FDA
EMA
Expiration
Code
PRUCALOPRIDE SUCCINATE, MOTEGRITY, TAKEDA PHARMS USA
2023-12-14NCE
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
A06: Drugs for constipation
A06A: Drugs for constipation
A06AX: Other drugs for constipation in atc
A06AX05: Prucalopride
HCPCS
No data
Clinical
Clinical Trials
62 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
ConstipationD003248HP_0002019K59.05592324
GastroparesisD018589EFO_1000948K31.841112
Gastroesophageal refluxD005764EFO_0003948K2122
Inflammatory bowel diseasesD015212EFO_0003767112
Crohn diseaseD003424EFO_0000384K5011
Celiac diseaseD002446EFO_0001060K90.011
Gastrointestinal hemorrhageD006471K92.211
Intestinal diseasesD007410HP_0002242K63.911
Patient satisfactionD01706011
Esophageal motility disordersD015154K22.411
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Diabetes mellitusD003920EFO_0000400E08-E13111
Irritable bowel syndromeD043183EFO_0000555K58111
Critical illnessD01663811
Intestinal pseudo-obstructionD007418EFO_1000988K56.011
Postoperative complicationsD01118311
Opioid-induced constipationD00007968911
Colonic neoplasmsD003110C1811
Colonic polypsD003111K63.511
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
DyspepsiaD004415EFO_0008533K301112
Deglutition disordersD003680HP_0002015R13.111
Urinary bladder neoplasmsD001749C6711
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients44
Hepatic insufficiencyD04855011
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
DepressionD003863F33.922
Mood disordersD019964EFO_0004247F30-F3922
Mental disordersD001523EFO_0000677F91.922
Depressive disorderD003866EFO_1002014F32.A22
CognitionD003071EFO_000392522
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePRUCALOPRIDE
INNprucalopride
Description
Prucalopride is a member of benzamides.
Classification
Small molecule
Drug classsulpride derivatives and analogs
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COCCCN1CCC(NC(=O)c2cc(Cl)c(N)c3c2OCC3)CC1
Identifiers
PDB
CAS-ID179474-81-8
RxCUI2107310
ChEMBL IDCHEMBL117287
ChEBI ID
PubChem CID3052762
DrugBankDB06480
UNII ID0A09IUW5TP (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
HTR4
HTR4
Organism
Homo sapiens
Gene name
HTR4
Gene synonyms
NCBI Gene ID
Protein name
5-hydroxytryptamine receptor 4
Protein synonyms
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled, cardiac 5-HT4 receptor, Serotonin receptor 4
Uniprot ID
Mouse ortholog
Htr4 (15562)
5-hydroxytryptamine receptor 4 (Q9R2A4)
Variants
Clinical Variant
No data
Financial
Resolor - Shire
$
£
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,038 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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14,000 adverse events reported
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