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Pipobroman
Vercyte (pipobroman) is a small molecule pharmaceutical. Pipobroman was first approved as Vercyte on 1982-01-01. It is used to treat leukemia and polycythemia vera in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
hemic and lymphatic diseasesD006425
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Pipobroman
Tradename
Company
Number
Date
Products
VERCYTEAbbott BiotherapeuticsN-016245 DISCN1982-01-01
2 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
leukemiaD007938C95
polycythemia veraD011087D45
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
L: Antineoplastic and immunomodulating agents
L01: Antineoplastic agents
L01A: Alkylating agents
L01AX: Other alkylating agents in atc
L01AX02: Pipobroman
HCPCS
No data
Clinical
Clinical Trials
5 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
MalariaD008288EFO_0001068B5444
AnemiaD000740EFO_0004272D64.911
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePIPOBROMAN
INNpipobroman
Description
Pipobroman is an N-acylpiperazine that is piperazine in which each of the nitrogens has been acylated by a 3-bromopropionoyl group. An anti-cancer drug. It has a role as an antineoplastic agent and an alkylating agent. It is a N-acylpiperazine, a tertiary carboxamide and an organobromine compound.
Classification
Small molecule
Drug class
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=C(CCBr)N1CCN(C(=O)CCBr)CC1
Identifiers
PDB
CAS-ID54-91-1
RxCUI8347
ChEMBL IDCHEMBL1585
ChEBI ID8242
PubChem CID4842
DrugBankDB00236
UNII ID6Q99RDT97R (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 250 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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238 adverse events reported
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