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Phenylpropanolamine
Capsule, Codamine, Triaminic (phenylpropanolamine) is a small molecule pharmaceutical. Phenylpropanolamine was first approved as Triaminic-12 on 1982-01-01. It is used to treat common cold, obesity, rhinitis, and urinary incontinence in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
respiratory tract diseasesD012140
otorhinolaryngologic diseasesD010038
urogenital diseasesD000091642
nutritional and metabolic diseasesD009750
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Chlorpheniramine maleate
+
Phenylpropanolamine hydrochloride
Tradename
Company
Number
Date
Products
COLD CAPSULE IVGRAHAM DMN-018793 DISCN1985-04-25
1 products
COLD CAPSULE VGRAHAM DMN-018794 DISCN1985-04-23
1 products
TRIAMINIC-12NovartisN-018115 DISCN1982-01-01
1 products
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Labels
FDA
EMA
Brand Name
Status
Last Update
triaminicOTC monograph final2020-12-17
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
common coldEFO_0007214D003139J00
obesityEFO_0001073D009765E66.9
rhinitisEFO_0008521D012220J31
urinary incontinenceHP_0000020D014549R32
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
R: Respiratory system drugs
R01: Nasal preparations
R01B: Nasal decongestants for systemic use
R01BA: Sympathomimetics
R01BA01: Phenylpropanolamine
R01BA51: Phenylpropanolamine, combinations
HCPCS
No data
Clinical
Clinical Trials
141 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Macular edemaD0082695315730
CataractD002386EFO_0001059H26.9310417
Retinal vein occlusionD012170EFO_1001157H34.811326
Postoperative painD010149G89.18426
InflammationD007249325
Dry eye syndromesD015352H04.12415
Corneal edemaD015715EFO_1000879H18.20213
Retinal detachmentD012163EFO_0005773H33.2123
Replacement arthroplasty kneeD019645213
Epiretinal membraneD019773HP_0100014123
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Multiple myelomaD009101C90.02114
LymphomaD008223C85.91214
NeoplasmsD009369C80112
LeukemiaD007938C95112
Large b-cell lymphoma diffuseD016403C83.311
TineaD014005EFO_0007510B35.411
AsthmaD001249EFO_0000270J4511
NeuroblastomaD009447EFO_000062111
Opsoclonus-myoclonus syndromeD053578EFO_100138311
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Non-hodgkin lymphomaD008228C85.922
Precursor cell lymphoblastic leukemia-lymphomaD054198C91.022
Hodgkin diseaseD006689C8122
B-cell lymphomaD01639311
Uveal neoplasmsD014604EFO_100123011
Wet macular degenerationD057135EFO_000468311
PseudophakiaD01959111
Fuchs' endothelial dystrophyD005642EFO_0003946H18.5111
Brain neoplasmsD001932EFO_0003833C7111
Breast neoplasmsD001943EFO_0003869C5011
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PlasmacytomaD010954C90.311
Lacrimal apparatus diseasesD007766HP_0009926H0411
Healthy volunteers/patients11
T-cell lymphomaD01639911
Retinal telangiectasisD058456Orphanet_190H35.0211
Retinal perforationsD012167EFO_100102811
Type 1 stickler syndromeC53749211
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Respiratory soundsD012135HP_0010307R06.111
PruritusD011537HP_0000989L2911
Cesarean sectionD00258511
Hypertrophic cicatrixD017439L91.011
CicatrixD002921HP_0100699L90.511
KeloidD007627EFO_0004212L91.011
Newborn respiratory distress syndromeD012127P2211
Deglutition disordersD003680HP_0002015R13.111
ThyroidectomyD01396511
InfertilityD007246EFO_000054511
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePHENYLPROPANOLAMINE
INNphenylpropanolamine
Description
(-)-norephedrine is an amphetamine that is propylbenzene substituted by a hydroxy group at position 1 and by an amino group at position 2 (the 1R,2S-stereoisomer). It is a plant alkaloid. It has a role as a plant metabolite. It is a member of amphetamines and a phenethylamine alkaloid.
Classification
Small molecule
Drug class
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(N)C(O)c1ccccc1
Identifiers
PDB
CAS-ID14838-15-4
RxCUI
ChEMBL IDCHEMBL61006
ChEBI ID
PubChem CID10297
DrugBankDB00397
UNII ID33RU150WUN (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 1,356 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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215 adverse events reported
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