Nityr, Orfadin (nitisinone) is a small molecule pharmaceutical. Nitisinone was first approved as Nityr on 2002-01-18. It is used to treat tyrosinemias in the USA. It has been approved in Europe to treat tyrosinemias. The pharmaceutical is active against 4-hydroxyphenylpyruvate dioxygenase. Orfadin's patents are valid until 2035-01-05 (FDA).