Mezlocillin
Mezlin (mezlocillin) is a small molecule pharmaceutical. Mezlocillin was first approved as Mezlin on 1982-01-01. It is used to treat escherichia coli infections, haemophilus infections, infectious skin diseases, klebsiella infections, and proteus infections amongst others in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
| respiratory tract diseases | D012140 |
| urogenital diseases | D000091642 |
| skin and connective tissue diseases | D017437 |
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Mezlocillin sodium monohydrate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| MEZLIN | Bayer | N-050549 DISCN | 1982-01-01 | 5 products |
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Labels
FDA
EMA
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| escherichia coli infections | EFO_1001318 | D004927 | B96.20 |
| haemophilus infections | EFO_1001127 | D006192 | — |
| infectious skin diseases | — | D012874 | — |
| klebsiella infections | EFO_1001353 | D007710 | — |
| proteus infections | EFO_1001130 | D011512 | — |
| pseudomonas infections | EFO_0001076 | D011552 | — |
| respiratory tract infections | — | D012141 | J06.9 |
| soft tissue infections | — | D018461 | — |
| streptococcal infections | EFO_1001476 | D013290 | — |
| urinary tract infections | EFO_0003103 | D014552 | N39.0 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
24 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Amyotrophic lateral sclerosis | D000690 | EFO_0000253 | G12.21 | — | 2 | — | 1 | — | 3 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myotonic dystrophy | D009223 | G71.11 | — | 2 | 2 | — | 1 | 5 | |
| Myotonic disorders | D020967 | Orphanet_606 | G71.1 | — | — | 1 | — | 1 | 2 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | — | 2 | — | — | 2 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | 2 | — | — | 2 |
| Cardiac arrhythmias | D001145 | EFO_0004269 | I49.9 | — | — | 2 | — | — | 2 |
| Ventricular fibrillation | D014693 | EFO_0004287 | I49.01 | — | — | 2 | — | — | 2 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | — | 1 | — | — | 1 |
| Heart arrest | D006323 | EFO_0009492 | I46 | — | — | 1 | — | — | 1 |
| Myotonia congenita | D009224 | G71.12 | — | — | 1 | — | — | 1 | |
| Ventricular tachycardia | D017180 | I47.2 | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Charcot-marie-tooth disease | D002607 | G60.0 | — | 1 | — | — | — | 1 | |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | 1 | — | — | — | 1 |
| Peripheral nervous system diseases | D010523 | G64 | — | 1 | — | — | — | 1 | |
| Myotonia | D009222 | — | 1 | — | — | — | 1 | ||
| Surgical amputation | D000671 | — | 1 | — | — | — | 1 | ||
| Chronic pain | D059350 | HP_0012532 | — | 1 | — | — | — | 1 | |
| Dystonia | D004421 | HP_0001332 | G24 | — | 1 | — | — | — | 1 |
| Blepharospasm | D001764 | G24.5 | — | 1 | — | — | — | 1 | |
| Spasm | D013035 | M62.83 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pharmacokinetics | D010599 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | MEZLOCILLIN |
| INN | mezlocillin |
| Description | Mezlocillin is a penicillin in which the substituent at position 6 of the penam ring is a (2R)-2-[3-(methanesulfonyl)-2-oxoimidazolidine-1-carboxamido]-2-phenylacetamido group. It has a role as an antibacterial drug. It is a penicillin and a penicillin allergen. It is a conjugate acid of a mezlocillin(1-). |
| Classification | Small molecule |
| Drug class | penicillins |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](NC(=O)N3CCN(S(C)(=O)=O)C3=O)c3ccccc3)C(=O)N2[C@H]1C(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 51481-65-3 |
| RxCUI | 6927 |
| ChEMBL ID | CHEMBL1731 |
| ChEBI ID | 6919 |
| PubChem CID | 656511 |
| DrugBank | DB00948 |
| UNII ID | OH2O403D1G (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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722 adverse events reported
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