Skip to content
Metyrapone
Metopirone (metyrapone) is a small molecule pharmaceutical. Metyrapone was first approved as Metopirone on 1982-01-01. The pharmaceutical is active against cytochrome P450 11B1, mitochondrial. In addition, it is known to target cytochrome P450 11B2, mitochondrial.
Download report
Favorite
Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
Metopirone
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Metyrapone
Tradename
Company
Number
Date
Products
METOPIRONEHRA PharmaN-012911 RX1996-08-09
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
metopironeNew Drug Application2020-02-14
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
V: Various drug classes in atc
— V04: Diagnostic agents
— V04C: Other diagnostic agents in atc
— V04CD: Pituitary function test diagnostic agents
— V04CD01: Metyrapone
HCPCS
No data
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common nameMETYRAPONE
INNmetyrapone
Description
Metyrapone is an aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency. It has a role as a diagnostic agent, an antimetabolite and an EC 1.14.15.4 (steroid 11beta-monooxygenase) inhibitor.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(C)(C(=O)c1cccnc1)c1cccnc1
Identifiers
PDB4ZF8
CAS-ID54-36-4
RxCUI6923
ChEMBL IDCHEMBL934
ChEBI ID44241
PubChem CID4174
DrugBankDB01011
UNII IDZS9KD92H6V (ChemIDplus, GSRS)
Target
Agency Approved
CYP11B1
CYP11B1
Organism
Homo sapiens
Gene name
CYP11B1
Gene synonyms
S11BH
NCBI Gene ID
1584
Protein name
cytochrome P450 11B1, mitochondrial
Protein synonyms
CYPXIB1, Cytochrome P-450c11, cytochrome p450 XIB1, cytochrome P450, family 11, subfamily B, polypeptide 1, cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 1, Cytochrome P450C11, Steroid 11-beta-hydroxylase, CYP11B1, steroid 11-beta-monooxygenase
Uniprot ID
Q9UML2
Mouse ortholog
—
—
Alternate
CYP11B2
CYP11B2
Organism
Homo sapiens
Gene name
CYP11B2
Gene synonyms
NCBI Gene ID
1585
Protein name
cytochrome P450 11B2, mitochondrial
Protein synonyms
ALDOS, Aldosterone synthase, Aldosterone-synthesizing enzyme, Corticosterone 18-monooxygenase, CYP11B2, CYPXIB2, Cytochrome P-450Aldo, Cytochrome P-450C18, cytochrome P450, family 11, subfamily B, polypeptide 2, cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2, mitochondrial cytochrome P450, family 11, subfamily B, polypeptide 2, Steroid 11-beta-hydroxylase, CYP11B2, steroid 11-beta-monooxygenase, steroid 11-beta/18-hydroxylase, Steroid 18-hydroxylase, steroid 18-hydroxylase, aldosterone synthase, P450C18, P450aldo
Uniprot ID
Q16726
Mouse ortholog
Cyp11b2 (13072)
cytochrome P450 11B2, mitochondrial (Q64661)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Additional graphs summarizing 3,220 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
1 adverse events reported
View more details