Skip to content
Primaxin, Recarbrio(imipenem)
Primaxin, Recarbrio (imipenem) is a small molecule pharmaceutical. Imipenem was first approved as Primaxin on 1985-11-26. It is used to treat bacterial endocarditis, bacterial infections, enterobacteriaceae infections, infectious bone diseases, and intraabdominal infections amongst others in the USA. It has been approved in Europe to treat gram-negative bacterial infections.
Download report
Favorite
FDA Novel Drug Approvals 2019
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
musculoskeletal diseasesD009140
respiratory tract diseasesD012140
urogenital diseasesD000091642
cardiovascular diseasesD002318
Trade Name
FDA
EMA
Combinations
Primaxin, Recarbrio (generic drugs available since 2011-12-21)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Cilastatin sodium
+
Imipenem
Tradename
Company
Number
Date
Products
PRIMAXINMerck KGaAN-050587 RX1985-11-26
1 products, RLD, RS
Show 2 discontinued
Cilastatin sodium
+
Imipenem
+
Relebactam
Tradename
Company
Number
Date
Products
RECARBRIOMerck Sharp & DohmeN-212819 RX2019-07-16
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
imipenem and cilastatin imipenem and cilastatin ANDA2022-10-11
primaxinANDA, New Drug Application2020-12-21
recarbrioNew Drug Application2021-04-09
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
bacterial endocarditisEFO_1000830D004697
bacterial infectionsD001424A49
enterobacteriaceae infectionsEFO_1001313D004756
infectious bone diseasesD001850
intraabdominal infectionsD059413
pelvic infectionD034161
pseudomonas infectionsEFO_0001076D011552
respiratory tract infectionsD012141J06.9
staphylococcal infectionsD013203A49.01
streptococcal infectionsEFO_1001476D013290
Show 1 more
Agency Specific
FDA
EMA
Expiration
Code
CILASTATIN SODIUM / IMIPENEM / RELEBACTAM, RECARBRIO, MSD MERCK CO
2029-07-16GAIN
2024-07-16NCE
Patent Expiration
Patent
Expires
Flag
FDA Information
Cilastatin Sodium / Imipenem / Relebactam, Recarbrio, Msd Merck Co
84870932029-11-19DS, DPU-2586, U-2587, U-2840
ATC Codes
J: Antiinfectives for systemic use
J01: Antibacterials for systemic use
J01D: Other beta-lactam antibacterials in atc
J01DH: Carbapenems
J01DH51: Imipenem and cilastatin
J01DH56: Imipenem, cilastatin and relebactam
HCPCS
Code
Description
J0742
Injection, imipenem 4 mg, cilastatin 4 mg and relebactam 2 mg
J0743
Injection, cilastatin sodium; imipenem, per 250 mg
Clinical
Clinical Trials
62 clinical trials
View more details
Mock data
Subscribe for the real data
Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Urinary tract infectionsD014552EFO_0003103N39.05319
Ventilator-associated pneumoniaD053717EFO_1001865J95.85113419
SepsisD018805A41.931115
Bacterial pneumoniaD018410EFO_1001272J15.92215
InfectionsD007239EFO_0000544134
PneumoniaD011014EFO_0003106J1811114
Critical illnessD016638213
Intraabdominal infectionsD0594131113
Hematologic neoplasmsD0193371112
Febrile neutropeniaD06414722
Show 8 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Bacterial infectionsD001424A4942117
Lung diseasesD008171EFO_0003818J98.4111
Iatrogenic diseaseD00704911
BacteremiaD016470EFO_0003033R78.8111
SinusitisD012852EFO_0007486J3211
AbscessD000038EFO_000303011
CellulitisD002481EFO_0003035L03.9011
Healthcare-associated pneumoniaD00007729911
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PyelonephritisD011704EFO_1001141N10-N1622
Abdominal abscessD018784EFO_100175311
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Communicable diseasesD00314111
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeutropeniaD009503D7011
Hematopoietic stem cell transplantationD01838011
Septic shockD012772A48.311
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common nameIMIPENEM
INNimipenem
Description
Imipenem is a broad-spectrum, intravenous beta-lactam antibiotic of the carbapenem subgroup. It has a role as an antibacterial drug. It is a beta-lactam antibiotic allergen and a member of carbapenems. It is a tautomer of an imipenem zwitterion.
Classification
Small molecule
Drug classantibacterial antibiotics, carbapenem derivatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
C[C@@H](O)[C@H]1C(=O)N2C(C(=O)O)=C(SCCNC=N)C[C@H]12
Identifiers
PDB
CAS-ID64221-86-9
RxCUI1545986
ChEMBL IDCHEMBL148
ChEBI ID471744
PubChem CID104838
DrugBankDB01598
UNII IDQ20IM7HE75 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
Primaxin - Merck Sharp & Dohme
$
£
Mock data
Subscribe for the real data
Mock data
Subscribe for the real data
Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Additional graphs summarizing 32,061 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
4,643 adverse events reported
View more details