Idebenone
Raxone (idebenone) is a small molecule pharmaceutical. Idebenone was first approved as Raxone on 2015-09-08. It has been approved in Europe to treat hereditary optic atrophy leber.
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Brand Name | Status | Last Update |
|---|---|---|
| lebody lab renewal dual effect idebenone serum | unapproved drug other | 2023-02-24 |
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Clinical
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30 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hereditary optic atrophy leber | D029242 | Orphanet_104 | H47.22 | — | 1 | 1 | 1 | 2 | 5 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | 1 | 1 | 1 | — | 2 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | — | — | 1 | 1 | — | 2 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Friedreich ataxia | D005621 | Orphanet_95 | G11.11 | 2 | 1 | 5 | — | — | 8 |
| Duchenne muscular dystrophy | D020388 | — | 2 | 3 | — | 1 | 6 | ||
| Rem sleep behavior disorder | D020187 | EFO_0007462 | G47.52 | — | 2 | 1 | — | — | 2 |
| Headache disorders | D020773 | EFO_0009550 | G44 | — | — | 1 | — | — | 1 |
| Ambulatory care | D000553 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic progressive multiple sclerosis | D020528 | 2 | 2 | — | — | — | 2 | ||
| Alcoholic fatty liver | D005235 | K70.0 | 1 | 1 | — | — | — | 1 | |
| Synucleinopathies | D000080874 | — | 1 | — | — | — | 1 | ||
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | 1 | 1 | — | — | — | 1 |
| Melas syndrome | D017241 | E88.41 | — | 1 | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | IDEBENONE |
| INN | idebenone |
| Description | Idebenone is a member of the class of 1,4-benzoquinones which is substituted by methoxy groups at positions 2 and 3, by a methyl group at positions 5, and by a 10-hydroxydecyl group at positions 6. Initially developed for the treatment of Alzheimer's disease, benefits were modest; it was subsequently found to be of benefit for the symptomatic treatment of Friedreich's ataxia. It has a role as an antioxidant and a ferroptosis inhibitor. It is a primary alcohol and a member of 1,4-benzoquinones. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | COC1=C(OC)C(=O)C(CCCCCCCCCCO)=C(C)C1=O |
Identifiers
| PDB | — |
| CAS-ID | 58186-27-9 |
| RxCUI | 51296 |
| ChEMBL ID | CHEMBL252556 |
| ChEBI ID | 31687 |
| PubChem CID | 3686 |
| DrugBank | DB09081 |
| UNII ID | HB6PN45W4J (ChemIDplus, GSRS) |
Target
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Safety
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Adverse Events
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3,187 adverse events reported
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