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Tenex, Intuniv(guanfacine)
Intuniv (guanfacine) is a small molecule pharmaceutical. Guanfacine was first approved as Tenex on 1986-10-27. It is used to treat attention deficit disorder with hyperactivity and hypertension in the USA. It has been approved in Europe to treat attention deficit disorder with hyperactivity. It is known to target alpha-2B adrenergic receptor, alpha-2C adrenergic receptor, and alpha-2A adrenergic receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
cardiovascular diseasesD002318
mental disordersD001523
Trade Name
FDA
EMA
Intuniv (generic drugs available since 1995-10-17, discontinued: Tenex)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Guanfacine hydrochloride
Tradename
Company
Number
Date
Products
INTUNIVTakedaN-022037 RX2009-09-02
4 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
guanfacineANDA2023-06-14
intunivNew Drug Application2021-01-26
tenex New Drug Application2013-05-08
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
attention deficit disorder with hyperactivityEFO_0003888D001289F90
hypertensionEFO_0000537D006973I10
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
C02: Antihypertensives
C02A: Antiadrenergic agents, centrally acting
C02AC: Imidazoline receptor agonists
C02AC02: Guanfacine
HCPCS
No data
Clinical
Clinical Trials
71 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Attention deficit disorder with hyperactivityD001289EFO_0003888F902711525
Cognitive dysfunctionD060825G31.84112
Prader-willi syndromeD011218Orphanet_739Q87.1122
Schizotypal personality disorderD012569F21112
Chronic painD059350HP_0012532112
Tourette syndromeD005879EFO_0004895F95.2112
Pervasive child development disordersD002659EFO_0003756F84112
SchizophreniaD012559EFO_0000692F2011
Psychotic disordersD011618F20.8111
Major depressive disorderD003865EFO_0003761F2211
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypertensionD006973EFO_0000537I10123
DeliriumD003693R41.0112
Alzheimer diseaseD000544EFO_0000249F0311
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Smoking cessationD016540EFO_000431922
SmokingD012907EFO_0003768F1722
Cocaine-related disordersD019970F14112
Critical illnessD01663811
Substance-related disordersD019966EFO_0003890F1311
Trigeminal neuralgiaD014277EFO_1001219G50.011
Alcohol abstinenceD064829111
Alcohol drinkingD000428EFO_000432911
Anxiety disordersD001008EFO_0006788F41.111
Separation anxietyD001010EFO_100191611
Show 3 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Marijuana abuseD002189EFO_0007191F1211
Healthy volunteers/patients11
AlcoholismD000437EFO_0003829F10.111
Post-traumatic stress disordersD013313EFO_0001358F43.111
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
BursitisD002062EFO_1000941M71.911
Postoperative nausea and vomitingD020250EFO_000488811
Postoperative painD010149G89.1811
Cognitive agingD00006649211
Borderline personality disorderD001883HP_0012076F60.311
Autistic disorderD001321EFO_0003758F84.011
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameGUANFACINE
INNguanfacine
Description
Guanfacine is a member of acetamides.
Classification
Small molecule
Drug classantihypertensives (guanidine deriviatives)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
N=C(N)NC(=O)Cc1c(Cl)cccc1Cl
Identifiers
PDB
CAS-ID29110-47-2
RxCUI40114
ChEMBL IDCHEMBL862
ChEBI ID5558
PubChem CID3519
DrugBankDB01018
UNII ID30OMY4G3MK (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
ADRA2B
ADRA2B
ADRA2C
ADRA2C
ADRA2A
ADRA2A
Organism
Homo sapiens
Gene name
ADRA2B
Gene synonyms
ADRA2L1, ADRA2RL1
NCBI Gene ID
Protein name
alpha-2B adrenergic receptor
Protein synonyms
ADRA2B adrenergic, alpha-2B-, receptor, Alpha-2 adrenergic receptor subtype C2, alpha-2-adrenergic receptor-like 1, Alpha-2B adrenoceptor, Alpha-2B adrenoreceptor, Alpha-2BAR, G-protein coupled receptor
Uniprot ID
Mouse ortholog
Adra2b (11552)
alpha-2B adrenergic receptor (P30545)
Variants
Clinical Variant
No data
Financial
Intuniv - Shire
$
£
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 2,836 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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4,397 adverse events reported
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