Skip to content
Echothiophate
Echothiophate is a small molecule pharmaceutical. Echothiophate was first approved as Phospholine iodide on 1982-01-01. It is known to target acetylcholinesterase.
Download report
Favorite
Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Echothiophate iodide
Tradename
Company
Number
Date
Products
PHOSPHOLINE IODIDEFera PharmaceuticalsN-011963 RX1982-01-01
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
phospholine iodideNew Drug Application2021-11-09
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
S: Sensory organ drugs
S01: Ophthalmologicals
S01E: Antiglaucoma preparations and miotics
S01EB: Parasympathomimetics, antiglaucoma preparations and miotics
S01EB03: Ecothiopate
HCPCS
No data
Clinical
Clinical Trials
1 clinical trials
View more details
Mock data
Subscribe for the real data
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common nameECHOTHIOPHATE
INN
Description
Ecothiopate is the phosphorothioate obtained by formal condensation of diethyl phosphate with N,N,N-trimethyl-2-sulfanylethanaminium. An irreversible acetylcholinesterase inhibitor, its iodide salt is used an ocular antihypertensive in the treatment of open-angle glaucoma, particularly when other drugs have proved inadequate. It has a role as an EC 3.1.1.8 (cholinesterase) inhibitor and a miotic. It is an organic thiophosphate, a member of phosphocholines and a quaternary ammonium ion.
Classification
Small molecule
Drug class
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCOP(=O)(OCC)SCC[N+](C)(C)C
Identifiers
PDB
CAS-ID6736-03-4
RxCUI89778
ChEMBL IDCHEMBL1201341
ChEBI ID4753
PubChem CID10548
DrugBankDB01057
UNII ID
Target
Agency Approved
No data
Alternate
ACHE
ACHE
Organism
Homo sapiens
Gene name
ACHE
Gene synonyms
NCBI Gene ID
Protein name
acetylcholinesterase
Protein synonyms
acetylcholinesterase (Yt blood group), apoptosis-related acetylcholinesterase, Yt blood group
Uniprot ID
Mouse ortholog
Ache (11423)
acetylcholinesterase (P21836)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Additional graphs summarizing 240 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
39 adverse events reported
View more details