Skip to content
Clarinex, Azomyr(desloratadine)
Aerinaze, Aerius, Azomyr, Clarinex, Neoclarityn (desloratadine) is a small molecule pharmaceutical. Desloratadine was first approved as Azomyr on 2001-01-15. It is used to treat allergic rhinitis perennial, allergic rhinitis seasonal, and urticaria in the USA. It has been approved in Europe to treat allergic rhinitis perennial, allergic rhinitis seasonal, and urticaria. The pharmaceutical is active against histamine H1 receptor.
Download report
Favorite
Searched
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
respiratory tract diseasesD012140
otorhinolaryngologic diseasesD010038
skin and connective tissue diseasesD017437
immune system diseasesD007154
Trade Name
FDA
EMA
Clarinex (generic drugs available since 2010-02-19)
Combinations
Clarinex (generic drugs available since 2010-02-19, discontinued: Clarinex d)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Desloratadine
Tradename
Company
Number
Date
Products
CLARINEXOrganonN-021165 RX2001-12-21
1 products, RLD, RS
Show 2 discontinued
Desloratadine
+
Pseudoephedrine sulfate
Tradename
Company
Number
Date
Products
CLARINEX-D 12 HOUROrganonN-021313 RX2006-02-01
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
clarinex-d 12 hourNew Drug Application2022-11-14
desloratadineANDA2023-02-06
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
allergic rhinitis perennialEFO_1001417D012221J30.89
allergic rhinitis seasonalEFO_0003956D006255J30
urticariaEFO_0005531D014581L50
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
R: Respiratory system drugs
R06: Antihistamines for systemic use
R06A: Antihistamines for systemic use
R06AX: Other antihistamines for systemic use in atc
R06AX27: Desloratadine
HCPCS
No data
Clinical
Clinical Trials
68 clinical trials
View more details
Mock data
Subscribe for the real data
Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Allergic rhinitis seasonalD006255EFO_0003956J301510117
UrticariaD014581EFO_0005531L5027312
Allergic rhinitisD065631J30.9718
Allergic rhinitis perennialD012221EFO_1001417J30.892316
Chronic urticariaD000080223L50.8246
HypersensitivityD006967EFO_0003785T78.401134
AsthmaD001249EFO_0000270J451124
Allergic conjunctivitisD003233EFO_0007141H10.44112
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Cold temperatureD00308011
EczemaD004485HP_0000964L30.911
DermatitisD003872HP_0011123L30.911
Atopic dermatitisD003876EFO_0000274L2011
Relapsing-remitting multiple sclerosisD020529EFO_000392911
Chronic progressive multiple sclerosisD02052811
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Non-small-cell lung carcinomaD00228911
RhinorrheaD00008672211
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients44
FastingD005215EFO_000275611
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
RhinitisD012220EFO_0008521J3144
PruritusD011537HP_0000989L2922
InflammationD00724911
Heat stress disordersD018882T67.211
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common nameDESLORATADINE
INNdesloratadine
Description
Desloratadine is loratadine in which the ethoxycarbonyl group attached to the piperidine ring is replaced by hydrogen. The major metabolite of loratidine, desloratadine is an antihistamine which is used for the symptomatic relief of allergic conditions including rhinitis and chronic urticaria. It does not readily enter the central nervous system, so does not cause drowsiness. It has a role as a H1-receptor antagonist, an anti-allergic agent, a cholinergic antagonist and a drug metabolite.
Classification
Small molecule
Drug classtricyclic histaminic-H1 receptor antagonists, loratadine derivatives (formerly-tadine)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Clc1ccc2c(c1)CCc1cccnc1C2=C1CCNCC1
Identifiers
PDB
CAS-ID100643-71-8
RxCUI275635
ChEMBL IDCHEMBL1172
ChEBI ID291342
PubChem CID124087
DrugBankDB00967
UNII IDFVF865388R (ChemIDplus, GSRS)
Target
Agency Approved
HRH1
HRH1
Organism
Homo sapiens
Gene name
HRH1
Gene synonyms
NCBI Gene ID
Protein name
histamine H1 receptor
Protein synonyms
histamine receptor, subclass H1
Uniprot ID
Mouse ortholog
Hrh1 (15465)
histamine H1 receptor (Q91XN3)
Alternate
No data
Variants
Clinical Variant
No data
Financial
Clarinex - Organon
$
£
Mock data
Subscribe for the real data
Mock data
Subscribe for the real data
Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Additional graphs summarizing 1,916 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
143,855 adverse events reported
View more details