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Colistin
Coly-mycin (colistin) is a protein pharmaceutical. Colistin was first approved as Coly-mycin s on 1982-01-01.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
Combinations
Coly-mycin
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Colistin sulfate
Tradename
Company
Number
Date
Products
COLY-MYCIN SPfizerN-050355 DISCN1982-01-01
1 products
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Colistin sulfate
+
Hydrocortisone acetate
+
Neomycin sulfate
+
Thonzonium bromide
Tradename
Company
Number
Date
Products
COLY-MYCIN SEndoN-050356 RX1982-01-01
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
coly-mycinNew Drug Application2018-12-03
cortisporin tcNew Drug Application2019-01-15
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
A07: Antidiarrheals, intestinal antiinflammatory/antiinfective agents
A07A: Intestinal antiinfectives
A07AA: Antibiotics, intestinal
A07AA10: Colistin
J: Antiinfectives for systemic use
J01: Antibacterials for systemic use
J01X: Other antibacterials in atc
J01XB: Polymyxins
J01XB01: Colistin
HCPCS
No data
Clinical
Clinical Trials
79 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Cocaine-related disordersD019970F143173342
Substance-related disordersD019966EFO_0003890F1311113
AlcoholismD000437EFO_0003829F10.111
EpistaxisD004844EFO_0003895R04.011
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Opioid-related disordersD009293EFO_0005611F1111
Human influenzaD007251EFO_0007328J11.1111
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Acute coronary syndromeD054058EFO_000567211
Chest painD002637HP_0100749R07.911
PharmacokineticsD01059911
Healthy volunteers/patients11
Impulsive behaviorD00717511
Substance withdrawal syndromeD013375EFO_000580011
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Macular degenerationD008268EFO_0001365H35.3011
Type 2 diabetes mellitusD003924EFO_0001360E1111
LactationD00777411
Pituitary acth hypersecretionD047748EFO_1001110E24.011
PainD010146EFO_0003843R5211
Respiratory insufficiencyD012131HP_0002093J96.911
AnesthesiaD00075811
Dental implantsD01592111
Dental impression techniqueD00376111
ObesityD009765EFO_0001073E66.911
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCOLISTIN
INNcolistin
Description
Colistin, also known as polymyxin E, is an antibiotic medication used as a last-resort treatment for multidrug-resistant Gram-negative infections including pneumonia. These may involve bacteria such as Pseudomonas aeruginosa, Klebsiella pneumoniae, or Acinetobacter. It comes in two forms: colistimethate sodium can be injected into a vein, injected into a muscle, or inhaled, and colistin sulfate is mainly applied to the skin or taken by mouth. Colistimethate sodium is a prodrug; it is produced by the reaction of colistin with formaldehyde and sodium bisulfite, which leads to the addition of a sulfomethyl group to the primary amines of colistin. Colistimethate sodium is less toxic than colistin when administered parenterally. In aqueous solutions it undergoes hydrolysis to form a complex mixture of partially sulfomethylated derivatives, as well as colistin. Resistance to colistin began to appear as of 2015.
Classification
Small molecule
Drug class
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H](CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)[C@@H](C)O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H](CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)[C@@H](C)O
Identifiers
PDB
CAS-ID1066-17-7
RxCUI2709
ChEMBL IDCHEMBL2221249
ChEBI ID
PubChem CID5311054
DrugBankDB00803
UNII IDZ67X93HJG1 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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10,890 adverse events reported
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