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Benzhydrocodone
Apadaz (benzhydrocodone) is a small molecule pharmaceutical. Benzhydrocodone was first approved as Apadaz on 2018-02-23. It is used to treat pain in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
signs and symptoms pathological conditionsD013568
psychological phenomenaD011579
musculoskeletal and neural physiological phenomenaD055687
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Acetaminophen
+
Benzhydrocodone hydrochloride
Tradename
Company
Number
Date
Products
APADAZKVK TechN-208653 DISCN2018-02-23
3 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
apadazNew Drug Application2021-03-12
benzhydrocodone and acetaminophenNDA authorized generic2021-03-17
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
painEFO_0003843D010146R52
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Acetaminophen / Benzhydrocodone Hydrochloride, Apadaz, Kvk Tech Inc
84611372031-02-22DS, DP
87484132030-07-10DS, DP
88289782030-07-01DP
91321252030-07-01DS, DPU-2249
95499232030-07-01DS, DP
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
6 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
MyopiaD009216H52.1112
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Conscious sedationD01629211
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Refractive errorsD012030EFO_0003908H52.711
BlepharitisD001762EFO_0009536H01.011
Lacrimal apparatus diseasesD007766HP_0009926H0411
Corneal diseasesD003316H18.911
MicrobiotaD06430711
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameBENZHYDROCODONE
INNbenzhydrocodone
Description
Benzhydrocodone (INN) (contracted from benzoate-hydrocodone) is an opioid prodrug of the morphinan class. Its chemical structure consists of hydrocodone coupled with benzoic acid. Benzhydrocodone itself is inactive and acts as a prodrug to hydrocodone upon cleavage of the benzoate portion of the molecule.
Classification
Small molecule
Drug class
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COc1ccc2c3c1O[C@H]1C(OC(=O)c4ccccc4)=CC[C@@H]4[C@@H](C2)N(C)CC[C@@]341
Identifiers
PDB
CAS-ID1259440-61-3
RxCUI
ChEMBL IDCHEMBL3137321
ChEBI ID
PubChem CID49836084
DrugBankDB15465
UNII ID75MS0AAZ9I (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 26 documents
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Safety
Black-box Warning
Black-box warning for: Apadaz, Benzhydrocodone and acetaminophen
Adverse Events
Top Adverse Reactions
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117 adverse events reported
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