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Doxorubicin hydrochloride, Caelyx pegylated liposomal(doxorubicin)
Doxil, Myocet, Pegylated (doxorubicin) is a small molecule pharmaceutical. Doxorubicin was first approved as Doxorubicin hydrochloride on 1982-01-01. It is used to treat breast neoplasms, gastrointestinal neoplasms, hodgkin disease, lung neoplasms, and myeloid leukemia acute amongst others in the USA. It has been approved in Europe to treat breast neoplasms, kaposi sarcoma, multiple myeloma, and ovarian neoplasms. It is known to target DNA topoisomerase 2-alpha and sorcin.
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Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
neoplasmsD009369
digestive system diseasesD004066
respiratory tract diseasesD012140
urogenital diseasesD000091642
cardiovascular diseasesD002318
hemic and lymphatic diseasesD006425
hereditary congenital and neonatal diseases and abnormalitiesD009358
skin and connective tissue diseasesD017437
endocrine system diseasesD004700
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Trade Name
FDA
EMA
Doxil (generic drugs available since 1989-03-17, discontinued: Adriamycin, Rubex)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Doxorubicin hydrochloride
Tradename
Company
Number
Date
Products
DOXIL (LIPOSOMAL)BaxterN-050718 RX1995-11-17
2 products, RLD
DOXORUBICIN HYDROCHLORIDEMylanN-050629 RX1987-12-23
3 products, RLD, RS
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Labels
FDA
EMA
Brand Name
Status
Last Update
adriamycinANDA2022-12-20
doxilNew Drug Application2019-08-12
doxorubicin hydrochlorideANDA2021-01-31
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
breast neoplasmsEFO_0003869D001943C50
gastrointestinal neoplasmsD005770C26.9
hodgkin diseaseD006689C81
lung neoplasmsD008175C34.90
myeloid leukemia acuteD015470C92.0
neuroblastomaEFO_0000621D009447
osteosarcomaD012516
ovarian neoplasmsEFO_0003893D010051C56
precursor cell lymphoblastic leukemia-lymphomaD054198C91.0
soft tissue neoplasmsD012983
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Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
L: Antineoplastic and immunomodulating agents
L01: Antineoplastic agents
L01D: Cytotoxic antibiotics and related substances
L01DB: Anthracyclines and related substances
L01DB01: Doxorubicin
HCPCS
Code
Description
J9000
Injection, doxorubicin hydrochloride, 10 mg
Q2049
Injection, doxorubicin hydrochloride, liposomal, imported lipodox, 10 mg
Q2050
Injection, doxorubicin hydrochloride, liposomal, not otherwise specified, 10 mg
Clinical
Clinical Trials
1708 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Breast neoplasmsD001943EFO_0003869C505720982932357
SarcomaD01250945813118148
Ovarian neoplasmsD010051EFO_0003893C5651603416136
Precursor cell lymphoblastic leukemia-lymphomaD054198C91.02337279290
Large b-cell lymphoma diffuseD016403C83.32748201280
Liver neoplasmsD008113EFO_1001513C22.01127161960
Multiple myelomaD009101C90.01339102154
Non-hodgkin lymphomaD008228C85.9152982249
Follicular lymphomaD008224C829123117
Mantle-cell lymphomaD020522C83.12114116
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
LymphomaD008223C85.9251034811172
NeoplasmsD009369C8062207383
Hodgkin diseaseD006689C8173820262
Fallopian tube neoplasmsD005185272313154
LeukemiaD007938C9562520248
Triple negative breast neoplasmsD0647261032746
NeuroblastomaD009447EFO_0000621102013245
Prostatic neoplasmsD011471C61815424
Endometrial neoplasmsD016889EFO_00042302121124
Ovarian epithelial carcinomaD00007721612103223
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Stomach neoplasmsD013274EFO_0003897C1645211
Male breast neoplasmsD01856747210
Pancreatic neoplasmsD010190EFO_0003860C255519
Neoplasm metastasisD009362EFO_00097083619
Myeloid leukemia acuteD015470C92.0448
Invasive hydatidiform moleD002820D39.288
Myelodysplastic syndromesD009190D46426
Head and neck neoplasmsD006258446
Adult t-cell leukemia-lymphomaD015459C91.5335
Biphenotypic leukemia acuteD015456C95.0145
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
CystadenocarcinomaD00353633
Appendiceal neoplasmsD001063EFO_0003880C18.1213
Myelodysplastic-myeloproliferative diseasesD05443722
Castration-resistant prostatic neoplasmsD06412911
Primary myelofibrosisD055728D47.411
Myelomonocytic leukemia chronicD015477C93.111
AnemiaD000740EFO_0004272D64.911
Leukemia myeloid chronic atypical bcr-abl negativeD054438C92.211
ThrombocytosisD013922D75.8311
HypersensitivityD006967EFO_0003785T78.4011
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Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
FatigueD005221HP_0012378R53.8311
NauseaD009325HP_0002018R11.011
Ataxia telangiectasiaD001260Orphanet_100G11.311
Therapeutic equivalencyD01381011
Takotsubo cardiomyopathyD054549EFO_1002000I51.8111
Liver transplantationD016031EFO_001068211
Adjuvant chemotherapyD01702411
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDOXORUBICIN
INNdoxorubicin
Description
Doxorubicin is a deoxy hexoside, an anthracycline, an anthracycline antibiotic, an aminoglycoside, a member of tetracenequinones, a member of p-quinones, a primary alpha-hydroxy ketone and a tertiary alpha-hydroxy ketone. It has a role as an Escherichia coli metabolite. It is a conjugate base of a doxorubicin(1+). It derives from a hydride of a tetracene.
Classification
Small molecule
Drug classantineoplastic antibiotics (daunorubicin type)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1
Identifiers
PDB5MRA
CAS-ID23214-92-8
RxCUI3639
ChEMBL IDCHEMBL53463
ChEBI ID28748
PubChem CID31703
DrugBankDB00997
UNII ID80168379AG (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
TOP2A
TOP2A
SRI
SRI
Organism
Homo sapiens
Gene name
TOP2A
Gene synonyms
TOP2
NCBI Gene ID
Protein name
DNA topoisomerase 2-alpha
Protein synonyms
DNA gyrase, DNA topoisomerase (ATP-hydrolyzing), DNA topoisomerase II, 170 kD, DNA topoisomerase II, alpha isozyme, topoisomerase (DNA) II alpha 170kDa
Uniprot ID
Mouse ortholog
Top2a (21973)
DNA topoisomerase 2-alpha (Q01320)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 170,871 documents
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Safety
Black-box Warning
Black-box warning for: Adriamycin, Doxil, Doxorubicin hydrochloride
Adverse Events
Top Adverse Reactions
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6,930 adverse events reported
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