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Taxotere(docetaxel)
Taxotere (docetaxel) is a small molecule pharmaceutical. Docetaxel was first approved as Taxotere on 1995-11-27. It is used to treat breast neoplasms, head and neck neoplasms, melanoma, non-small-cell lung carcinoma, and ovarian neoplasms amongst others in the USA. It has been approved in Europe to treat adenocarcinoma, adenoma, breast neoplasms, head and neck neoplasms, and non-small-cell lung carcinoma amongst others. The pharmaceutical is active against tubulin beta chain.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
digestive system diseasesD004066
respiratory tract diseasesD012140
urogenital diseasesD000091642
skin and connective tissue diseasesD017437
endocrine system diseasesD004700
Trade Name
FDA
EMA
Taxotere (generic drugs available since 2014-11-05, discontinued: Docefrez)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Docetaxel
Tradename
Company
Number
Date
Products
DOCETAXELACCORD HLTHCAREN-201195 RX2012-04-20
3 products, RLD, RS
DOCETAXELAllerganN-203551 RX2013-04-12
4 products
DOCETAXELHospiraN-022234 RX2011-03-08
6 products, RLD, RS
DOCETAXELMeridian LaboratoryN-215813 PEND2022-11-22
3 products, RLD
DOCETAXELSandozN-201525 RX2011-06-29
3 products
TAXOTERESanofiN-020449 RX2010-08-02
3 products, RLD, RS
DOCETAXELShilpa MedicareN-205934 RX2015-12-22
3 products, RLD, RS
DOCETAXELsparcN-022534 RX2019-01-08
3 products
Show 6 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
docetaxelANDA2023-06-16
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
breast neoplasmsEFO_0003869D001943C50
head and neck neoplasmsD006258
melanomaD008545
non-small-cell lung carcinomaD002289
ovarian neoplasmsEFO_0003893D010051C56
pancreatic neoplasmsEFO_0003860D010190C25
prostatic neoplasmsD011471C61
soft tissue neoplasmsD012983
stomach neoplasmsEFO_0003897D013274C16
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Docetaxel, Docetaxel, Shilpa
89407862033-09-30DPU-1789
93081952033-09-30DP
97638802033-09-30U-2558, U-2559, U-2560, U-2561, U-2562, U-2563, U-2564
108427702031-08-07DPU-2998
ATC Codes
L: Antineoplastic and immunomodulating agents
L01: Antineoplastic agents
L01C: Plant alkaloids and other natural products, antineoplastic drugs
L01CD: Taxanes, antineoplastic
L01CD02: Docetaxel
HCPCS
Code
Description
J9171
Injection, docetaxel, 1 mg
Clinical
Clinical Trials
2027 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Breast neoplasmsD001943EFO_0003869C50612471411721454
Non-small-cell lung carcinomaD0022897121410068355
Prostatic neoplasmsD011471C61711724719266
Head and neck neoplasmsD00625823629185
Squamous cell neoplasmsD01830752751132
Male breast neoplasmsD01856734218
Chemical and drug induced liver injuryD05648611
Second primary neoplasmsD01660911
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369C801275094164
Stomach neoplasmsD013274EFO_0003897C1620105245134
Lung neoplasmsD008175C34.902989212126
Squamous cell carcinoma of head and neckD000077195204511163
Esophageal neoplasmsD004938C15164511262
Ovarian neoplasmsD010051EFO_0003893C5620354155
AdenocarcinomaD0002307419153
Castration-resistant prostatic neoplasmsD06412913238239
Pancreatic neoplasmsD010190EFO_0003860C2510311239
SarcomaD0125091323333
Show 63 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Colorectal neoplasmsD015179127113
MelanomaD0085458712
Biliary tract neoplasmsD001661C24.9415
Kidney neoplasmsD007680EFO_0003865C64425
Gallbladder neoplasmsD005706EFO_0004606C231315
CholangiocarcinomaD018281C22.1155
Invasive hydatidiform moleD002820D39.2144
Liver neoplasmsD008113EFO_1001513C22.0314
Malignant pleural effusionD016066J91.033
HemangiosarcomaD00639433
Show 53 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Myeloid leukemia acuteD015470C92.022
Hematologic neoplasmsD01933722
Colonic neoplasmsD003110C1822
Liver diseasesD008107EFO_0001421K70-K7711
Renal insufficiencyD051437HP_0000083N1911
Myelomonocytic leukemia chronicD015477C93.111
Non-hodgkin lymphomaD008228C85.911
B-cell chronic lymphocytic leukemiaD015451C91.111
ChondrosarcomaD00281311
Paraneoplastic syndromesD01025711
Show 6 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
MalnutritionD044342EFO_0008572E40-E4622
Urogenital neoplasmsD014565EFO_0003863D0711
Drug-related side effects and adverse reactionsD064420T88.711
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDOCETAXEL
INNdocetaxel
Description
Docetaxel anhydrous is a tetracyclic diterpenoid that is paclitaxel with the N-benzyloxycarbonyl group replaced by N-tert-butoxycarbonyl, and the acetoxy group at position 10 replaced by a hydroxy group. It has a role as an antineoplastic agent, a photosensitizing agent and an antimalarial. It is a tetracyclic diterpenoid and a secondary alpha-hydroxy ketone. It derives from a hydride of a taxane.
Classification
Small molecule
Drug classantineoplastics, taxane derivatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C.O.O.O
Identifiers
PDB
CAS-ID114977-28-5
RxCUI1299922
ChEMBL IDCHEMBL3545252
ChEBI ID59809
PubChem CID148124
DrugBankDB01248
UNII ID699121PHCA (ChemIDplus, GSRS)
Target
Agency Approved
TUBB
TUBB
Organism
Homo sapiens
Gene name
TUBB
Gene synonyms
TUBB5
NCBI Gene ID
Protein name
tubulin beta chain
Protein synonyms
beta Ib tubulin, epididymis secretory sperm binding protein, tubulin beta-1 chain, Tubulin beta-5 chain, tubulin, beta polypeptide
Uniprot ID
Mouse ortholog
Tubb5 (22154)
tubulin beta-5 chain (Q3UF52)
Alternate
No data
Variants
Clinical Variant
No data
Financial
Docetaxel - Eagle Pharmaceuticals
$
£
Mock data
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 77,257 documents
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Safety
Black-box Warning
Black-box warning for: Docetaxel
Adverse Events
Top Adverse Reactions
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405 adverse events reported
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