Disulfiram
Antabuse (disulfiram) is a small molecule pharmaceutical. Disulfiram was first approved as Antabuse on 1982-01-01. It is used to treat alcoholism in the USA. It is known to target aldehyde dehydrogenase, mitochondrial.
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Disulfiram
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ANTABUSE | Teva | N-007883 DISCN | 1982-01-01 | 2 products, RLD |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| antabuse | ANDA | 2012-04-18 |
| disulfiram | ANDA | 2022-11-21 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| alcoholism | EFO_0003829 | D000437 | F10.1 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N07: Other nervous system drugs in atc
— N07B: Drugs used in addictive disorders
— N07BB: Drugs used in alcohol dependence
— N07BB01: Disulfiram
P: Antiparasitic products, insecticides and repellents
— P03: Ectoparasiticides, incl. scabicides, insecticides and repellents
— P03A: Ectoparasiticides, incl. scabicides
— P03AA: Sulfur containing product ectoparasiticides
— P03AA04: Disulfiram
— P03AA54: Disulfiram, combinations
HCPCS
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Clinical
Clinical Trials
68 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Erectile dysfunction | D007172 | EFO_0004234 | F52.21 | — | 1 | — | 1 | 4 | 6 |
| Arterial occlusive diseases | D001157 | EFO_0009085 | 1 | — | 1 | 1 | — | 3 | |
| St elevation myocardial infarction | D000072657 | — | — | — | 2 | — | 2 | ||
| Induced labor | D007751 | — | — | — | 2 | — | 2 | ||
| Obstetric labor complications | D007744 | — | 1 | 1 | 1 | — | 2 | ||
| Postpartum hemorrhage | D006473 | O72 | — | — | — | 1 | 1 | 2 | |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | — | — | 1 | — | 1 |
| Ischemia | D007511 | EFO_0000556 | — | — | — | 1 | — | 1 | |
| Chronic renal insufficiency | D051436 | N18 | — | — | — | 1 | — | 1 | |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart failure | D006333 | EFO_0003144 | I50 | — | — | 1 | — | 1 | 2 |
| Prostatic neoplasms | D011471 | C61 | — | 1 | 1 | — | — | 2 | |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | 1 | 1 | — | — | 1 |
| Labor pain | D048949 | — | — | 1 | — | — | 1 | ||
| Percutaneous coronary intervention | D062645 | — | — | 1 | — | — | 1 | ||
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | — | 2 | — | — | 1 | 3 |
| Covid-19 | D000086382 | U07.1 | — | 1 | — | — | 1 | 2 | |
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | — | 1 | — | — | 1 | 2 |
| Respiratory insufficiency | D012131 | HP_0002093 | J96.9 | — | 2 | — | — | — | 2 |
| Newborn respiratory distress syndrome | D012127 | P22 | — | 2 | — | — | — | 2 | |
| Extracorporeal membrane oxygenation | D015199 | — | 1 | — | — | — | 1 | ||
| Systemic scleroderma | D012595 | EFO_0000717 | M34 | — | 1 | — | — | — | 1 |
| Streptococcal infections | D013290 | EFO_1001476 | — | 1 | — | — | — | 1 | |
| Peripheral arterial disease | D058729 | EFO_0004265 | — | 1 | — | — | — | 1 | |
| Ischemic optic neuropathy | D018917 | EFO_1000809 | H47.01 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Congenital heart defects | D006330 | HP_0001627 | Q24.9 | 1 | — | — | — | 1 | 2 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | 1 | — | — | — | — | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Penile neoplasms | D010412 | C60 | — | — | — | — | 1 | 1 | |
| Raynaud disease | D011928 | EFO_1001145 | I73.0 | — | — | — | — | 1 | 1 |
| Sleep | D012890 | GO_0030431 | — | — | — | — | 1 | 1 | |
| Psychological distress | D000079225 | — | — | — | — | 1 | 1 | ||
| Professional burnout | D002055 | — | — | — | — | 1 | 1 | ||
| Anxiety | D001007 | EFO_0005230 | F41.1 | — | — | — | — | 1 | 1 |
| Affect | D000339 | — | — | — | — | 1 | 1 | ||
| Pituitary acth hypersecretion | D047748 | EFO_1001110 | E24.0 | — | — | — | — | 1 | 1 |
| Pyloric stenosis | D011707 | K31.1 | — | — | — | — | 1 | 1 | |
| Mesenteric ischemia | D065666 | K55.1 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | DISULFIRAM |
| INN | disulfiram |
| Description | Disulfiram is an organic disulfide that results from the formal oxidative dimerisation of N,N-diethyldithiocarbamic acid. A multi-enzyme inhibitor that is used in alcohol aversion therapy and also exhibits anticancer properties. It has a role as an EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor, an angiogenesis inhibitor, an EC 3.1.1.8 (cholinesterase) inhibitor, an EC 3.1.1.1 (carboxylesterase) inhibitor, an EC 5.99.1.2 (DNA topoisomerase) inhibitor, a fungicide, an apoptosis inducer, a NF-kappaB inhibitor, an antineoplastic agent and a ferroptosis inducer. It is an organic disulfide and an organosulfur acaricide. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CCN(CC)C(=S)SSC(=S)N(CC)CC |
Identifiers
| PDB | — |
| CAS-ID | 97-77-8 |
| RxCUI | 3554 |
| ChEMBL ID | CHEMBL964 |
| ChEBI ID | 4659 |
| PubChem CID | 3117 |
| DrugBank | DB00822 |
| UNII ID | TR3MLJ1UAI (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
ALDH2
ALDH2
Organism
Homo sapiens
Gene name
ALDH2
Gene synonyms
ALDM
NCBI Gene ID
Protein name
aldehyde dehydrogenase, mitochondrial
Protein synonyms
acetaldehyde dehydrogenase 2, aldehyde dehydrogenase 2 family (mitochondrial), ALDH class 2, ALDH-E2, ALDHI, epididymis secretory sperm binding protein, liver mitochondrial ALDH, nucleus-encoded mitochondrial aldehyde dehydrogenase 2
Uniprot ID
Mouse ortholog
Aldh2 (11669)
aldehyde dehydrogenase, mitochondrial (P47738)
Variants
Clinical Variant
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
Black-box warning for: Antabuse
Adverse Events
Top Adverse Reactions
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58,860 adverse events reported
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