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Dihydroergotamine
Embolex, Migranal, Trudhesa (dihydroergotamine) is a small molecule pharmaceutical. Dihydroergotamine was first approved as D.h.e. 45 on 1982-01-01. It is used to treat cluster headache, migraine disorders, orthostatic hypotension, postpartum hemorrhage, and xerostomia in the USA. The pharmaceutical is active against 5-hydroxytryptamine receptor 1D. In addition, it is known to target 5-hydroxytryptamine receptor 1F, 5-hydroxytryptamine receptor 1E, 5-hydroxytryptamine receptor 7, 5-hydroxytryptamine receptor 1B, and 5-hydroxytryptamine receptor 6.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
stomatognathic diseasesD009057
nervous system diseasesD009422
urogenital diseasesD000091642
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Migranal, Trudhesa (generic drugs available since 2003-04-28, discontinued: D.h.e. 45)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Dihydroergotamine mesylate
Tradename
Company
Number
Date
Products
MIGRANALBausch Health CompaniesN-020148 RX1997-12-08
1 products, RLD, RS
TRUDHESAImpel PharmaceuticalsN-213436 RX2021-09-02
1 products, RLD, RS
Show 1 discontinued
Dihydroergotamine mesylate
+
Heparin sodium
+
Lidocaine hydrochloride
Tradename
Company
Number
Date
Products
EMBOLEXNovartisN-018885 DISCN1984-11-30
2 products
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Labels
FDA
EMA
Brand Name
Status
Last Update
dihydroergotamine mesylateANDA2023-04-24
migranalNew Drug Application2019-07-05
trudhesaNew Drug Application2021-09-17
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
cluster headacheHP_0012199D003027G44.00
migraine disordersEFO_0003821D008881G43
orthostatic hypotension—D007024I95.1
postpartum hemorrhage—D006473O72
xerostomia—D014987K11.7
Agency Specific
FDA
EMA
Expiration
Code
DIHYDROERGOTAMINE MESYLATE, TRUDHESA, IMPEL PHARMS
2024-09-02NP
Patent Expiration
Patent
Expires
Flag
FDA Information
Dihydroergotamine Mesylate, Trudhesa, Impel Pharms
111854972039-01-04U-3218
112667992036-11-05DP
99191172033-03-17DPU-3218
109402782033-01-23DP
105072952032-12-25DP
95500362032-09-05DP
ATC Codes
N: Nervous system drugs
— N02: Analgesics
— N02C: Antimigraine preparations
— N02CA: Ergot alkaloids, antimigraine
— N02CA01: Dihydroergotamine
— N02CA51: Dihydroergotamine, combinations
HCPCS
Code
Description
J1110
Injection, dihydroergotamine mesylate, per 1 mg
Clinical
Clinical Trials
1 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PainD010146EFO_0003843R52———1—1
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDIHYDROERGOTAMINE
INNdihydroergotamine
Description
Dihydroergotamine is ergotamine in which a single bond replaces the double bond between positions 9 and 10. A semisynthetic ergot alkaloid with weaker oxytocic and vasoconstrictor properties than ergotamine, it is used (as the methanesulfonic or tartaric acid salts) for the treatment of migraine and orthostatic hypotension. It has a role as a serotonergic agonist, a non-narcotic analgesic, a vasoconstrictor agent, a dopamine agonist and a sympatholytic agent. It is an ergot alkaloid and a semisynthetic derivative.
Classification
Small molecule
Drug classergot alkaloid deriviatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CN1C[C@H](C(=O)N[C@]2(C)O[C@@]3(O)[C@@H]4CCCN4C(=O)[C@H](Cc4ccccc4)N3C2=O)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21
Identifiers
PDB4IAQ
CAS-ID511-12-6
RxCUI3418
ChEMBL IDCHEMBL1732
ChEBI ID4562
PubChem CID10531
DrugBankDB00320
UNII ID436O5HM03C (ChemIDplus, GSRS)
Target
Agency Approved
HTR1D
HTR1D
Organism
Homo sapiens
Gene name
HTR1D
Gene synonyms
HTR1DA, HTRL
NCBI Gene ID
3352
Protein name
5-hydroxytryptamine receptor 1D
Protein synonyms
5-HT-1D, 5-HT-1D-alpha, 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled, Serotonin 1D alpha receptor, Serotonin receptor 1D
Uniprot ID
P28221
Mouse ortholog
Htr1d (15552)
5-hydroxytryptamine receptor 1D (Q8BUW7)
Alternate
HTR1F
HTR1F
HTR1E
HTR1E
HTR7
HTR7
HTR1B
HTR1B
HTR6
HTR6
Organism
Homo sapiens
Gene name
HTR1F
Gene synonyms
HTR1EL
NCBI Gene ID
3355
Protein name
5-hydroxytryptamine receptor 1F
Protein synonyms
5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled, Serotonin receptor 1F
Uniprot ID
P30939
Mouse ortholog
Htr1f (15557)
5-hydroxytryptamine receptor 1F (Q02284)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,918 documents
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Safety
Black-box Warning
Black-box warning for: Dihydroergotamine mesylate, Migranal, Trudhesa
Adverse Events
Top Adverse Reactions
Mock data
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2,522 adverse events reported
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