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Digoxin
Lanoxin (digoxin) is a small molecule pharmaceutical. Digoxin was first approved as Lanoxin on 1982-01-01. It is used to treat anxiety disorders, atrial fibrillation, atrial flutter, cardiogenic shock, and heart failure amongst others in the USA. The pharmaceutical is active against sodium/potassium-transporting ATPase subunit alpha-1. In addition, it is known to target solute carrier organic anion transporter family member 4C1.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
mental disordersD001523
Trade Name
FDA
EMA
Lanoxin (generic drugs available since 1982-01-01, discontinued: Lanoxicaps)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Digoxin
Tradename
Company
Number
Date
Products
LANOXINConcordia LaboratoriesN-020405 RX1997-09-30
3 products, RLD, RS
LANOXINCovis PharmaN-009330 RX1982-01-01
1 products, RLD, RS
LANOXIN PEDIATRICCovis PharmaN-009330 RX1982-01-01
1 products, RLD, RS
DIGOXINHikma PharmaceuticalsN-021648 RX2004-08-26
1 products, RLD, RS
Show 2 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
lanoxinNew Drug Application2022-11-02
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
anxiety disordersEFO_0006788D001008F41.1
atrial fibrillationEFO_0000275D001281I48.0
atrial flutterEFO_0003911D001282
cardiogenic shockD012770R57.0
heart failureEFO_0003144D006333I50
low cardiac outputD002303
supraventricular tachycardiaHP_0004755D013617I47.1
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
C01: Cardiac therapy drugs
C01A: Cardiac glycosides
C01AA: Digitalis glycosides
C01AA05: Digoxin
HCPCS
Code
Description
J1160
Injection, digoxin, up to 0.5 mg
J1162
Injection, digoxin immune fab (ovine), per vial
Clinical
Clinical Trials
172 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients53154
Atrial fibrillationD001281EFO_0000275I48.0154414
Heart failureD006333EFO_0003144I50136211
Dilated cardiomyopathyD002311EFO_0000407I42.011
Acute kidney injuryD058186HP_0001919N1711
HypertensionD006973EFO_0000537I1011
Renal dialysisD006435EFO_0010690Z99.211
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Heart diseasesD006331EFO_0003777I51.9213
Supraventricular tachycardiaD013617HP_0004755I47.1213
Cardiac arrhythmiasD001145EFO_0004269I49.922
Pre-eclampsiaD011225EFO_0000668O14212
Cardiovascular diseasesD002318EFO_0000319I9811
Atrial flutterD001282EFO_000391111
HypotensionD007022EFO_0005251I9511
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Rheumatoid arthritisD001172EFO_0000685M06.9415
Breast neoplasmsD001943EFO_0003869C50224
Pancreatic neoplasmsD010190EFO_0003860C25112
Prostatic neoplasmsD011471C61112
Non-alcoholic fatty liver diseaseD065626EFO_0003095K75.81112
Myelodysplastic syndromesD009190D46111
Myeloid leukemia acuteD015470C92.0111
Head and neck neoplasmsD006258111
Non-small-cell lung carcinomaD00228911
Actinic keratosisD055623L57.011
Show 6 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369C8099
Drug interactionsD00434777
Type 2 diabetes mellitusD003924EFO_0001360E1155
MelanomaD00854522
Hiv infectionsD015658EFO_0000764B2022
EpilepsyD004827EFO_0000474G40.922
PharmacokineticsD01059922
Hereditary angioedemasD054179EFO_000413111
VomitingD014839HP_0002013R11.111
Human influenzaD007251EFO_0007328J11.111
Show 19 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Induced abortionD00002833
Congenital heart defectsD006330HP_0001627Q24.911
Exercise testD005080EFO_000432811
CardiomyopathiesD009202EFO_0000318I4211
Medullary thyroid cancerC53691411
Liver cirrhosisD008103EFO_0001422K74.011
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDIGOXIN
INNdigoxin
Description
Digoxin is a cardenolide glycoside that is digitoxin beta-hydroxylated at C-12. A cardiac glycoside extracted from the foxglove plant, Digitalis lanata, it is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation, but the margin between toxic and therapeutic doses is small. It has a role as an epitope, an anti-arrhythmia drug, a cardiotonic drug and an EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor. It is a cardenolide glycoside and a steroid saponin. It is a conjugate acid of a digoxin(1-).
Classification
Small molecule
Drug classfluoroquinolone derivatives, nonantibacterial indication (e.g., antineoplastic antibiotics)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
C[C@H]1O[C@@H](O[C@H]2[C@@H](O)C[C@H](O[C@H]3[C@@H](O)C[C@H](O[C@H]4CC[C@]5(C)[C@H]6C[C@@H](O)[C@]7(C)[C@@H](C8=CC(=O)OC8)CC[C@]7(O)[C@@H]6CC[C@@H]5C4)O[C@@H]3C)O[C@@H]2C)C[C@H](O)[C@@H]1O
Identifiers
PDB7DDH
CAS-ID20830-75-5
RxCUI3407
ChEMBL IDCHEMBL1751
ChEBI ID4551
PubChem CID2724385
DrugBankDB00390
UNII ID73K4184T59 (ChemIDplus, GSRS)
Target
Agency Approved
ATP1A1
ATP1A1
Organism
Homo sapiens
Gene name
ATP1A1
Gene synonyms
NCBI Gene ID
Protein name
sodium/potassium-transporting ATPase subunit alpha-1
Protein synonyms
ATPase, Na+/K+ transporting, alpha 1 polypeptide, Na(+)/K(+) ATPase alpha-1 subunit, Na+/K+ ATPase 1, Na, K-ATPase, alpha-A catalytic polypeptide, Na,K-ATPase alpha-1 subunit, Na,K-ATPase catalytic subunit alpha-A protein, Sodium pump subunit alpha-1, sodium-potassium ATPase catalytic subunit alpha-1, sodium-potassium-ATPase, alpha 1 polypeptide
Uniprot ID
Mouse ortholog
Atp1a1 (11928)
sodium/potassium-transporting ATPase subunit alpha-1 (Q91Z09)
Alternate
SLCO4C1
SLCO4C1
Organism
Homo sapiens
Gene name
SLCO4C1
Gene synonyms
OATP4C1, OATPX, SLC21A20
NCBI Gene ID
Protein name
solute carrier organic anion transporter family member 4C1
Protein synonyms
OATP-H, OATP-M1, OATP4C1, Organic anion transporter M1, Organic anion transporting polypeptide 4C1, Solute carrier family 21 member 20
Uniprot ID
Mouse ortholog
Slco4c1 (227394)
solute carrier organic anion transporter family member 4C1 (Q8BGD4)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 28,602 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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59,282 adverse events reported
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