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Diflunisal
Dolobid (diflunisal) is a small molecule pharmaceutical. Diflunisal was first approved as Dolobid on 1982-04-19. It is used to treat osteoarthritis, pain, and rheumatoid arthritis in the USA. It is known to target dihydrofolate reductase.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
musculoskeletal diseasesD009140
skin and connective tissue diseasesD017437
immune system diseasesD007154
signs and symptoms pathological conditionsD013568
psychological phenomenaD011579
musculoskeletal and neural physiological phenomenaD055687
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Diflunisal
Tradename
Company
Number
Date
Products
DOLOBIDMerck KGaAN-018445 DISCN1982-04-19
2 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
diflunisalANDA2023-02-01
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
osteoarthritisEFO_0002506D010003M15-M19
painEFO_0003843D010146R52
rheumatoid arthritisEFO_0000685D001172M06.9
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N02: Analgesics
— N02B: Other analgesics and antipyretics in atc
— N02BA: Salicylic acid and derivatives, analgesics and antipyretics
— N02BA11: Diflunisal
HCPCS
No data
Clinical
Clinical Trials
2 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Prostatic neoplasmsD011471C61—11——2
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDIFLUNISAL
INNdiflunisal
Description
Diflunisal is an organofluorine compound comprising salicylic acid having a 2,4-difluorophenyl group at the 5-position. It has a role as a non-steroidal anti-inflammatory drug and a non-narcotic analgesic. It is an organofluorine compound and a monohydroxybenzoic acid. It is functionally related to a salicylic acid and a 1,3-difluorobenzene.
Classification
Small molecule
Drug classanti-inflammatory agents (salicylic acid derivatives)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=C(O)c1cc(-c2ccc(F)cc2F)ccc1O
Identifiers
PDB—
CAS-ID22494-42-4
RxCUI3393
ChEMBL IDCHEMBL898
ChEBI ID39669
PubChem CID3059
DrugBankDB00861
UNII ID7C546U4DEN (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
DHFR
DHFR
Organism
Homo sapiens
Gene name
DHFR
Gene synonyms
NCBI Gene ID
1719
Protein name
dihydrofolate reductase
Protein synonyms
Uniprot ID
Q6IRW8
Mouse ortholog
Dhfr (13361)
dihydrofolate reductase (Q61579)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,750 documents
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Safety
Black-box Warning
Black-box warning for: Diflunisal
Adverse Events
Top Adverse Reactions
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49 adverse events reported
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