Diethylcarbamazine
Hetrazan (diethylcarbamazine) is a small molecule pharmaceutical. Diethylcarbamazine was first approved as Hetrazan on 1982-01-01. It is used to treat filarial elephantiasis, loiasis, and pulmonary eosinophilia in the USA.
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Diethylcarbamazine citrate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| HETRAZAN | Lederle Laboratories | N-006459 DISCN | 1982-01-01 | 1 products |
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Labels
FDA
EMA
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| filarial elephantiasis | EFO_0007272 | D004605 | B74.0 |
| loiasis | — | D008118 | B74.3 |
| pulmonary eosinophilia | EFO_0007257 | D011657 | J82.81 |
Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
50 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Endometriosis | D004715 | EFO_0001065 | N80 | 1 | 4 | 5 | 1 | 12 | 21 |
| Contraception | D003267 | — | 1 | 2 | 1 | — | 4 | ||
| Adenomyosis | D062788 | EFO_1001757 | N80.0 | — | — | — | 1 | 2 | 3 |
| Leiomyoma | D007889 | HP_0000131 | D25 | — | — | — | 2 | — | 2 |
| Ovarian reserve | D065851 | EFO_0004770 | — | 1 | — | 1 | — | 2 | |
| Infertility | D007246 | EFO_0000545 | — | — | — | 1 | 1 | 2 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Metrorrhagia | D008796 | HP_0100608 | N92.1 | — | — | 3 | — | — | 3 |
| Premenstrual syndrome | D011293 | N94.3 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anorexia nervosa | D000856 | EFO_0004215 | F50.0 | — | 1 | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pregnancy rate | D018873 | — | — | — | — | 1 | 1 | ||
| Hormonal contraception | D000080282 | — | — | — | — | 1 | 1 | ||
| Fibromyalgia | D005356 | EFO_0005687 | M79.1 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | DIETHYLCARBAMAZINE |
| INN | diethylcarbamazine |
| Description | Diethylcarbamazine is a N-methylpiperazine and a N-carbamoylpiperazine. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CCN(CC)C(=O)N1CCN(C)CC1 |
Identifiers
| PDB | — |
| CAS-ID | 90-89-1 |
| RxCUI | 3384 |
| ChEMBL ID | CHEMBL684 |
| ChEBI ID | 4527 |
| PubChem CID | 3052 |
| DrugBank | DB00711 |
| UNII ID | V867Q8X3ZD (ChemIDplus, GSRS) |
Target
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Alternate
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Variants
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Trends
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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1,074 adverse events reported
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