Skip to content
Dichlorphenamide
Keveyis (dichlorphenamide) is a small molecule pharmaceutical. Dichlorphenamide was first approved as Daranide on 1982-01-01. It is used to treat glaucoma in the USA. It is known to target carbonic anhydrase 1, carbonic anhydrase 12, and carbonic anhydrase 4.
Download report
Favorite
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
eye diseasesD005128
Trade Name
FDA
EMA
Keveyis (generic drugs available since 2022-12-29, discontinued: Daranide)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Dichlorphenamide
Tradename
Company
Number
Date
Products
KEVEYISXeris Biopharma HoldingsN-011366 RX2015-08-07
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
dichlorphenamideNDA authorized generic2023-03-10
keveyisNew Drug Application2021-12-13
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
glaucomaEFO_0000516D005901H40
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
S: Sensory organ drugs
S01: Ophthalmologicals
S01E: Antiglaucoma preparations and miotics
S01EC: Carbonic anhydrase inhibitors, antiglaucoma drugs and miotics
S01EC02: Diclofenamide
HCPCS
No data
Clinical
Clinical Trials
17 clinical trials
View more details
Mock data
Subscribe for the real data
Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Congenital abnormalitiesD000013EFO_0003915Q89.911
GastroschisisD020139EFO_1000949Q79.311
Meconium ileusD000074270P76.011
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
InfertilityD007246EFO_000054511
Urethral strictureD014525HP_0012227N3511
Colonic neoplasmsD003110C1811
Inflammatory bowel diseasesD015212EFO_000376711
Colonic polypsD003111K63.511
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Fecal impactionD005244K56.4111
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Intestinal obstructionD007415K56.6011
Colorectal neoplasmsD01517911
GallstonesD042882EFO_000421011
CholecystitisD002764HP_0001082K8111
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common nameDICHLORPHENAMIDE
INNdiclofenamide
Description
Diclofenamide is a sulfonamide that is benzene-1,3-disulfonamide in which the hydrogens at positions 4 and 5 are substituted by chlorine. An oral carbonic anhydrase inhibitor, it partially suppresses the secretion (inflow) of aqueous humor in the eye and so reduces intraocular pressure. It is used for the treatment of glaucoma. It has a role as an EC 4.2.1.1 (carbonic anhydrase) inhibitor, an antiglaucoma drug and an ophthalmology drug. It is a sulfonamide and a dichlorobenzene.
Classification
Small molecule
Drug class
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
NS(=O)(=O)c1cc(Cl)c(Cl)c(S(N)(=O)=O)c1
Identifiers
PDB
CAS-ID120-97-8
RxCUI
ChEMBL IDCHEMBL17
ChEBI ID101085
PubChem CID3038
DrugBankDB01144
UNII IDVVJ6673MHY (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CA1
CA1
CA12
CA12
CA4
CA4
Organism
Homo sapiens
Gene name
CA1
Gene synonyms
NCBI Gene ID
Protein name
carbonic anhydrase 1
Protein synonyms
CA-I, CAB, Carbonate dehydratase I, Carbonic anhydrase B, Carbonic anhydrase I, Cyanamide hydratase CA1, epididymis secretory protein Li 11, epididymis secretory sperm binding protein
Uniprot ID
Mouse ortholog
Car1 (12346)
carbonic anhydrase 1 (Q9DC84)
Variants
Clinical Variant
No data
Financial
Keveyis - Strongbridge Biopharma
$
£
Mock data
Subscribe for the real data
Mock data
Subscribe for the real data
Keveyis - Xeris Biopharma Holdings
$
£
Mock data
Subscribe for the real data
Mock data
Subscribe for the real data
Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Additional graphs summarizing 245 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
293 adverse events reported
View more details