Dezocine
Dalgan (dezocine) is a small molecule pharmaceutical. Dezocine was first approved as Dalgan on 1989-12-29. It is used to treat pain in the USA.
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Drug Products
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Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Dezocine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DALGAN | AstraZeneca | N-019082 DISCN | 1989-12-29 | 3 products |
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Labels
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| pain | EFO_0003843 | D010146 | R52 |
Agency Specific
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HCPCS
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Clinical
Clinical Trials
164 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anesthesia | D000758 | — | 1 | 3 | 6 | 10 | 19 | ||
| General anesthesia | D000768 | 1 | 1 | 1 | 1 | 4 | 7 | ||
| Obesity | D009765 | EFO_0001073 | E66.9 | — | 1 | — | 3 | 1 | 5 |
| Delirium | D003693 | R41.0 | — | — | — | 3 | 2 | 5 | |
| Postoperative cognitive complications | D000079690 | 1 | 1 | — | 2 | 2 | 5 | ||
| Coronary artery bypass | D001026 | EFO_0003776 | — | — | — | 1 | 2 | 3 | |
| Colorectal neoplasms | D015179 | — | 1 | — | 1 | 1 | 3 | ||
| Arthritis | D001168 | EFO_0005856 | M05-M14 | — | — | — | 2 | — | 2 |
| Delayed emergence from anesthesia | D055191 | — | — | — | 1 | 1 | 2 | ||
| Prostatic neoplasms | D011471 | C61 | — | — | — | 2 | — | 2 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postoperative nausea and vomiting | D020250 | EFO_0004888 | — | 1 | — | — | 1 | 2 | |
| Replacement arthroplasty knee | D019645 | — | 1 | — | — | — | 1 | ||
| Orthopedic procedures | D019637 | — | 1 | — | — | — | 1 | ||
| Down syndrome | D004314 | EFO_0001064 | Q90 | — | 1 | — | — | — | 1 |
| Kidney transplantation | D016030 | — | 1 | — | — | — | 1 | ||
| Drug-related side effects and adverse reactions | D064420 | T88.7 | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hip fractures | D006620 | EFO_0003964 | S72.00 | — | — | — | — | 2 | 2 |
| Anesthesia recovery period | D000762 | — | — | — | — | 2 | 2 | ||
| Inhalation anesthesia | D000769 | — | — | — | — | 2 | 2 | ||
| Pituitary neoplasms | D010911 | — | — | — | — | 2 | 2 | ||
| Dna damage | D004249 | — | — | — | — | 2 | 2 | ||
| Hypotension | D007022 | EFO_0005251 | I95 | — | — | — | — | 1 | 1 |
| Rhytidoplasty | D015361 | — | — | — | — | 1 | 1 | ||
| Sleep wake disorders | D012893 | G47 | — | — | — | — | 1 | 1 | |
| Animal mammary neoplasms | D015674 | — | — | — | — | 1 | 1 | ||
| Enhanced recovery after surgery | D000080482 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | DEZOCINE |
| INN | dezocine |
| Description | Dezocine is (7S,8S)-7-Amino-8-methyl-5,6,7,8-tetrahydronaphthalen-2-ol in which the hydrogen at position 8 and one of the hydrogens at position 6 are substituted by each end of a tetramethylene bridge. A synthetic opioid analgesic, it has mixed opiod agonist and antagonist properties. Although it is used for pain management, it can produce opioid withdrawal syndrome in patients already dependent on other opioids, and its clinical application is limited by side effects such as dizziness. It has a role as an opioid analgesic. It is a member of phenols and a primary amino compound. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | C[C@@]12CCCCC[C@@H](Cc3ccc(O)cc31)[C@@H]2N |
Identifiers
| PDB | — |
| CAS-ID | 53648-55-8 |
| RxCUI | 22713 |
| ChEMBL ID | CHEMBL1685 |
| ChEBI ID | 4474 |
| PubChem CID | 3033053 |
| DrugBank | DB01209 |
| UNII ID | VHX8K5SV4X (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
Clinical Variant
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Trends
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Additional graphs summarizing 579 documents
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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1,071 adverse events reported
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