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Desmopressin
Ddavp, Nocdurna (desmopressin) is a protein pharmaceutical. Desmopressin was first approved as Ddavp on 1982-01-01. It is used to treat enuresis, hemorrhage, neurogenic diabetes insipidus, thrombocytopenia, and von willebrand diseases in the USA. It is known to target vasopressin V1b receptor, vasopressin V2 receptor, vasopressin V1a receptor, and oxytocin receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
urogenital diseasesD000091642
hemic and lymphatic diseasesD006425
hereditary congenital and neonatal diseases and abnormalitiesD009358
endocrine system diseasesD004700
signs and symptoms pathological conditionsD013568
behavior and behavior mechanismsD001520
mental disordersD001523
Trade Name
FDA
EMA
Ddavp, Nocdurna (generic drugs available since 1997-10-15, discontinued: Concentraid, Minirin, Noctiva, Stimate)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Desmopressin acetate
Tradename
Company
Number
Date
Products
DDAVPFerring PharmaceuticalsN-018938 RX1984-03-30
1 products, RLD, RS
DDAVPFerring PharmaceuticalsN-019955 RX1995-09-06
2 products, RLD, RS
NOCDURNAFerring PharmaceuticalsN-022517 RX2018-06-21
2 products, RLD, RS
Show 9 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
ddavpNew Drug Application2021-07-20
desmopressin acetateANDA2023-06-06
nocdurnaNew Drug Application2020-12-03
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
enuresisD004775R32
hemorrhageMP_0001914D006470R58
neurogenic diabetes insipidusHP_0000863D020790
thrombocytopeniaHP_0001873D013921D69.6
von willebrand diseasesOrphanet_903D014842D68.0
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Desmopressin Acetate, Noctiva, Acerus Pharms
95393022030-06-15DP
114199142030-06-15U-3431
77997612024-09-26DP
Desmopressin Acetate, Nocdurna, Ferring Pharms Inc
99748262030-04-13U-2326, U-2327
101371672029-05-21U-2327
110204482029-05-21U-2327
75604292024-02-02DPU-2326
79476542023-12-29DP
88026242023-12-29U-2326
92207472023-05-07U-2326
95046472023-05-07DPU-2326
99190252023-05-07U-2326
103074592023-05-07DP
ATC Codes
H: Systemic hormonal preparations, excl. sex hormones and insulins
H01: Pituitary and hypothalamic hormones and analogues
H01B: Posterior pituitary lobe hormones
H01BA: Vasopressin and analogues
H01BA02: Desmopressin
HCPCS
Code
Description
J2597
Injection, desmopressin acetate, per 1 mcg
Clinical
Clinical Trials
38 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
DepressionD003863F33.9431311
Substance-related disordersD019966EFO_0003890F13213
Major depressive disorderD003865EFO_0003761F221113
Chronic painD059350HP_001253211
Neuroaxonal dystrophiesD01915011
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
AlcoholismD000437EFO_0003829F10.1112
Depressive disorderD003866EFO_1002014F32.A112
Irritable bowel syndromeD043183EFO_0000555K58112
Gastroesophageal refluxD005764EFO_0003948K2111
PainD010146EFO_0003843R5211
Herpes zosterD006562EFO_0006510B0211
Post-traumatic stress disordersD013313EFO_0001358F43.111
Abdominal painD015746R10.911
ConstipationD003248HP_0002019K59.011
Functional colonic diseasesD00310911
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Cocaine-related disordersD019970F1433
Back painD001416HP_0003418M5422
Obstructive sleep apneaD020181EFO_0003918G47.3322
Dual (psychiatry) diagnosisD01783111
SchizophreniaD012559EFO_0000692F2011
SciaticaD012585HP_0011868M54.311
Small cell lung carcinomaD05575211
Neuroendocrine tumorsD018358EFO_1001901D3A.811
Rett syndromeD015518F84.211
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients33
NeoplasmsD009369C8011
Erectile dysfunctionD007172EFO_0004234F52.2111
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Multiple myelomaD009101C90.011
DyspepsiaD004415EFO_0008533K3011
Vulvar diseasesD01484511
Anxiety disordersD001008EFO_0006788F41.111
Personality disordersD010554HP_0012075F60.611
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDESMOPRESSIN
INNdesmopressin
Description
Desmopressin is a synthetic analogue of vasopressin in which 3-mercaptopropionic acid replaces the cysteine residue at position 1 and D-arginine replaces the residue at position 8. An antidiuretic, it increases urine concentration and decreases urine production, and is used (usually as the trihydrate of the acetic acid salt) to prevent and control excessive thirst, urination, and dehydration caused by injury, surgery, and certain medical conditions. It is also used in the diagnosis and treatment of cranial diabetes insipidus and in tests of renal function. It has a role as a vasopressin receptor agonist, a renal agent and a diagnostic agent.
Classification
Protein
Drug classvasoconstrictors (vasopressin derivatives)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O
Identifiers
PDB
CAS-ID16679-58-6
RxCUI3251
ChEMBL IDCHEMBL1429
ChEBI ID4450
PubChem CID5311065
DrugBankDB00035
UNII IDENR1LLB0FP (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
AVPR1B
AVPR1B
AVPR2
AVPR2
AVPR1A
AVPR1A
OXTR
OXTR
Organism
Homo sapiens
Gene name
AVPR1B
Gene synonyms
AVPR3, VPR3
NCBI Gene ID
Protein name
vasopressin V1b receptor
Protein synonyms
Antidiuretic hormone receptor 1b, arginine vasopressin receptor 3, AVPR V1b, AVPR V3, pituitary vasopressin receptor 3, V1B receptor, Vasopressin V3 receptor
Uniprot ID
Mouse ortholog
Avpr1b (26361)
vasopressin V1b receptor (Q9WU02)
Variants
Clinical Variant
No data
Financial
Noctiva - Avadel Pharmaceuticals
$
£
Mock data
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 7,365 documents
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Safety
Black-box Warning
Black-box warning for: Desmopressin acetate, Nocdurna
Adverse Events
Top Adverse Reactions
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595 adverse events reported
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