Deserpidine
Enduronyl, Harmonyl, Oreticyl (deserpidine) is a small molecule pharmaceutical. Deserpidine was first approved as Harmonyl on 1982-01-01. It is used to treat dyskinesias, hypertension, and schizophrenia in the USA.
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Trade Name
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EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Deserpidine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| HARMONYL | AbbVie | N-010796 DISCN | 1982-01-01 | 2 products |
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Deserpidine
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Labels
FDA
EMA
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| dyskinesias | — | D020820 | G24 |
| hypertension | EFO_0000537 | D006973 | I10 |
| schizophrenia | EFO_0000692 | D012559 | F20 |
Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
C: Cardiovascular system drugs
— C02: Antihypertensives
— C02A: Antiadrenergic agents, centrally acting
— C02AA: Rauwolfia alkaloids, centrally acting antiadrenergic
— C02AA05: Deserpidine
— C02L: Antihypertensives and diuretics in combination
— C02LA: Rauwolfia alkaloids and diuretics in combination
— C02LA03: Deserpidine and diuretics
HCPCS
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Clinical
Clinical Trials
34 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Endometriosis | D004715 | EFO_0001065 | N80 | — | 2 | 1 | 1 | — | 4 |
| Infertility | D007246 | EFO_0000545 | — | — | 1 | 1 | — | 2 | |
| Ovarian cysts | D010048 | HP_0000138 | N83.1 | — | — | — | 1 | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Thrombocytopenic purpura idiopathic | D016553 | EFO_0007160 | D69.3 | 1 | 8 | — | — | — | 8 |
| Dyskeratosis congenita | D019871 | 1 | 2 | — | — | — | 2 | ||
| Telomere shortening | D059506 | 1 | 2 | — | — | — | 2 | ||
| Anemia | D000740 | EFO_0004272 | D64.9 | — | 1 | — | — | — | 1 |
| Pulmonary fibrosis | D011658 | J84.10 | — | 1 | — | — | — | 1 | |
| Aplastic anemia | D000741 | HP_0001915 | D61.9 | 1 | 1 | — | — | — | 1 |
| Fanconi anemia | D005199 | Orphanet_84 | D61.09 | 1 | 1 | — | — | — | 1 |
| Thrombotic thrombocytopenic purpura | D011697 | M31.19 | — | 1 | — | — | — | 1 | |
| Fibrocystic breast disease | D005348 | N60 | — | 1 | — | — | — | 1 | |
| Endometrial neoplasms | D016889 | EFO_0004230 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ovarian reserve | D065851 | EFO_0004770 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | DESERPIDINE |
| INN | deserpidine |
| Description | Deserpidine is an alkaloid ester, a methyl ester, a benzoate ester, an organic heteropentacyclic compound and a yohimban alkaloid. It derives from a hydride of a yohimban. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5ccccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC |
Identifiers
| PDB | — |
| CAS-ID | 131-01-1 |
| RxCUI | 62174 |
| ChEMBL ID | CHEMBL1200515 |
| ChEBI ID | 27478 |
| PubChem CID | 8550 |
| DrugBank | DB01089 |
| UNII ID | 9016E3VB47 (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
Clinical Variant
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Financial
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Trends
PubMed Central
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Additional graphs summarizing 129 documents
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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488 adverse events reported
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