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Dapiprazole
Dapiprazole is a small molecule pharmaceutical. Dapiprazole was first approved as Dapiprazole hydrochloride on 1990-12-31. It is used to treat mydriasis in the USA. The pharmaceutical is active against alpha-1D adrenergic receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
eye diseasesD005128
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Dapiprazole hydrochloride
Tradename
Company
Number
Date
Products
DAPIPRAZOLE HYDROCHLORIDEFera PharmaceuticalsN-019849 DISCN1990-12-31
1 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
dapiprazoleANDA2019-06-11
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
mydriasisHP_0011499D015878H57.04
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01E: Antiglaucoma preparations and miotics
— S01EX: Other antiglaucoma preparations in atc
— S01EX02: Dapiprazole
HCPCS
No data
Clinical
Clinical Trials
11 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Ventricular tachycardiaD017180I47.2—11——1
Heat stress disordersD018882T67.2——1——1
HyperthermiaD000084462—11——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Intracranial vasospasmD020301EFO_1000994G45.922———2
Multiple sclerosisD009103EFO_0003885G3511———1
Diabetes mellitusD003920EFO_0000400E08-E1311———1
AtaxiaD001259R27.011———1
Wolfram syndromeD014929Orphanet_3463E13.811———1
Healthy volunteers/patients——1———1
Heat strokeD018883EFO_1001340T67.01—1———1
Subarachnoid hemorrhageD013345EFO_0000713I6011———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDAPIPRAZOLE
INNdapiprazole
Description
Dapiprazole is a N-arylpiperazine, a N-alkylpiperazine and a member of pyridines. It has a role as an alpha-adrenergic antagonist, a miotic, an ophthalmology drug and an antipsychotic agent.
Classification
Small molecule
Drug classantiulcer agents (benzimidazole derivatives)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cc1ccccc1N1CCN(CCc2nnc3n2CCCC3)CC1
Identifiers
PDB—
CAS-ID72822-12-9
RxCUI22298
ChEMBL IDCHEMBL1201216
ChEBI ID51066
PubChem CID3033538
DrugBankDB00298
UNII ID5RNZ8GJO7K (ChemIDplus, GSRS)
Target
Agency Approved
ADRA1D
ADRA1D
Organism
Homo sapiens
Gene name
ADRA1D
Gene synonyms
ADRA1A
NCBI Gene ID
146
Protein name
alpha-1D adrenergic receptor
Protein synonyms
adrenergic, alpha -1D-, receptor, adrenergic, alpha-1A-, receptor, Alpha-1A adrenergic receptor, Alpha-1D adrenoceptor, Alpha-1D adrenoreceptor, Alpha-adrenergic receptor 1a
Uniprot ID
Q9NPY0
Mouse ortholog
Adra1d (11550)
alpha-1D adrenergic receptor (P97714)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 69 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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594 adverse events reported
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