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Danazol
Danocrine (danazol) is a small molecule pharmaceutical. Danazol was first approved as Danocrine on 1982-01-01. It is used to treat endometriosis and fibrocystic breast disease in the USA. The pharmaceutical is active against androgen receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
urogenital diseasesD000091642
skin and connective tissue diseasesD017437
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Danazol
Tradename
Company
Number
Date
Products
DANOCRINESanofiN-017557 DISCN1982-01-01
3 products
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Labels
FDA
EMA
Brand Name
Status
Last Update
danazolANDA2023-03-03
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
endometriosisEFO_0001065D004715N80
fibrocystic breast diseaseD005348N60
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
G: Genito urinary system and sex hormones
G03: Sex hormones and modulators of the genital system
G03X: Other sex hormones and modulators of the genital system in atc
G03XA: Antigonadotropins and similar agents
G03XA01: Danazol
HCPCS
Code
Description
G9507
Documentation that the patient is on a statin medication or has documentation of a valid contraindication or exception to statin medications; contraindications/exceptions that can be defined by diagnosis codes include pregnancy during the measurement period, active liver disease, rhabdomyolysis, end stage renal disease on dialysis and heart failure; provider documented contraindications/exceptions include breastfeeding during the measurement period, woman of child-bearing age not actively taking birth control, allergy to statin, drug interaction (hiv protease inhibitors, nefazodone, cyclosporine, gemfibrozil, and danazol) and intolerance (with supporting documentation of trying a statin at least once within the last 5 years or diagnosis codes for myostitis or toxic myopathy related to drugs)
Clinical
Clinical Trials
162 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
MelanomaD0085451234201162
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hodgkin diseaseD006689C8132311136
LymphomaD008223C85.998118
SarcomaD012509383113
LeiomyosarcomaD0078901347
Uveal neoplasmsD014604EFO_1001230516
NeuroblastomaD009447EFO_00006211315
NeoplasmsD009369C802214
Synovial sarcomaD013584112
Skin neoplasmsD012878EFO_0004198C4411
Alveolar soft part sarcomaD01823411
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hiv infectionsD015658EFO_0000764B20133
Neuroendocrine tumorsD018358EFO_1001901D3A.822
Neoplasm metastasisD009362EFO_000970822
Thyroid neoplasmsD013964EFO_0003841111
T-cell lymphoma peripheralD016411C84.911
Solitary fibrous tumorsD05436411
ImmunotherapyD00716711
NeurofibrosarcomaD01831911
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Small cell lung carcinomaD05575211
Carcinoid tumorD002276D3A.0011
Parathyroid neoplasmsD01028211
Breast neoplasmsD001943EFO_0003869C5011
Lung neoplasmsD008175C34.9011
Kidney neoplasmsD007680EFO_0003865C6411
Colonic neoplasmsD003110C1811
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDANAZOL
INNdanazol
Description
Danazol is a 17beta-hydroxy steroid and a terminal acetylenic compound. It has a role as an anti-estrogen, an estrogen antagonist and a geroprotector. It derives from a hydride of a pregnane.
Classification
Small molecule
Drug classAndrogen; Anabolic steroid; Progestogen; Progestin; Antigonadotropin; Steroidogenesis inhibitor; Antiestrogen
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C
Identifiers
PDB
CAS-ID17230-88-5
RxCUI3102
ChEMBL IDCHEMBL1479
ChEBI ID4315
PubChem CID28417
DrugBankDB01406
UNII IDN29QWW3BUO (ChemIDplus, GSRS)
Target
Agency Approved
AR
AR
Organism
Homo sapiens
Gene name
AR
Gene synonyms
DHTR, NR3C4
NCBI Gene ID
Protein name
androgen receptor
Protein synonyms
Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4
Uniprot ID
Mouse ortholog
Ar (11835)
androgen receptor (P19091)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 3,946 documents
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Safety
Black-box Warning
Black-box warning for: Danazol
Adverse Events
Top Adverse Reactions
Mock data
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4,676 adverse events reported
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