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Dacarbazine
Dtic-dome (dacarbazine) is a small molecule pharmaceutical. Dacarbazine was first approved as Dtic-dome on 1982-01-01. It is used to treat fibrosarcoma, hodgkin disease, islet cell carcinoma, medullary carcinoma, and melanoma amongst others in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
digestive system diseasesD004066
hemic and lymphatic diseasesD006425
endocrine system diseasesD004700
immune system diseasesD007154
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Dacarbazine
Tradename
Company
Number
Date
Products
DTIC-DOMEBayerN-017575 DISCN1982-01-01
2 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
dacarbazine ANDA2022-10-20
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
fibrosarcomaD005354
hodgkin diseaseD006689C81
islet cell carcinomaD018273C25.4
medullary carcinomaD018276
melanomaD008545
neuroblastomaEFO_0000621D009447
rhabdomyosarcomaD012208
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
L: Antineoplastic and immunomodulating agents
L01: Antineoplastic agents
L01A: Alkylating agents
L01AX: Other alkylating agents in atc
L01AX04: Dacarbazine
HCPCS
Code
Description
J9130
Dacarbazine, 100 mg
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDACARBAZINE
INNdacarbazine
Description
(E)-dacarbazine is a dacarbazine in which the N=N double bond adopts a trans-configuration.
Classification
Small molecule
Drug class
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CN(C)/N=N/c1[nH]cnc1C(N)=O
Identifiers
PDB
CAS-ID4342-03-4
RxCUI3098
ChEMBL IDCHEMBL476
ChEBI ID
PubChem CID135398738
DrugBankDB00851
UNII ID7GR28W0FJI (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 13,567 documents
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Safety
Black-box Warning
Black-box warning for: Dacarbazine
Adverse Events
Top Adverse Reactions
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1 adverse events reported
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