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Corticotropin
Acthar, Cortrophin (corticotropin) is a protein pharmaceutical. Corticotropin was first approved as Purified cortrophin gel on 1982-01-01. It is used to treat collagen diseases, erythema multiforme, infantile spasms, multiple sclerosis, and nephrotic syndrome amongst others in the USA. The pharmaceutical is active against adrenocorticotropic hormone receptor. In addition, it is known to target CRHR1-IT1-CRHR1 protein, melanocortin receptor 5, melanocortin receptor 4, melanocyte-stimulating hormone receptor, melanocortin receptor 3, and corticotropin-releasing factor receptor 2.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
musculoskeletal diseasesD009140
nervous system diseasesD009422
eye diseasesD005128
urogenital diseasesD000091642
hemic and lymphatic diseasesD006425
skin and connective tissue diseasesD017437
immune system diseasesD007154
chemically-induced disordersD064419
Trade Name
FDA
EMA
Acthar, Cortrophin (discontinued: Acth)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Corticotropin
Tradename
Company
Number
Date
Products
PURIFIED CORTROPHIN GELANI PHARMSN-008975 RX1982-01-01
1 products, RLD, RS
ACTHAR GELMallinckrodtN-008372 RX1982-01-01
1 products, RLD, RS
Show 5 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
actharNew Drug Application2021-03-11
purified cortrophin gelNew Drug Application2021-11-01
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
collagen diseasesD003095
erythema multiformeD004892L51
infantile spasmsEFO_1000643D013036G40.82
multiple sclerosisEFO_0003885D009103G35
nephrotic syndromeEFO_0004255D009404N04
optic neuritisEFO_0007405D009902H46
rheumatic diseasesD012216M79.0
sarcoidosisEFO_0000690D012507D80-D89
serum sicknessD012713T80.6
uveitisEFO_1001231D014605H20.9
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
H: Systemic hormonal preparations, excl. sex hormones and insulins
H01: Pituitary and hypothalamic hormones and analogues
H01A: Anterior pituitary lobe hormones and analogues
H01AA: Acth and synthetic analog preparations
H01AA01: Corticotropin
HCPCS
Code
Description
J0800
Injection, corticotropin, up to 40 units
Clinical
Clinical Trials
209 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Postoperative painD010149G89.182419216
HypertensionD006973EFO_0000537I10436113
PainD010146EFO_0003843R521532212
Neonatal abstinence syndromeD009357EFO_0005799P96.132318
DeliriumD003693R41.01247
Attention deficit disorder with hyperactivityD001289EFO_0003888F901326
Opioid-related disordersD009293EFO_0005611F1122115
Knee osteoarthritisD020370EFO_0004616M17224
Labor painD048949314
Critical illnessD016638224
Show 54 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Diabetic neuropathiesD003929EFO_1000783415
Substance-related disordersD019966EFO_0003890F131213
HyperalgesiaD006930112
NeoplasmsD009369C80112
Laron syndromeD046150Orphanet_633E34.32122
Fecal incontinenceD005242R15112
Emergence deliriumD0000712571112
Pain managementD059408112
Post-traumatic stress disordersD013313EFO_0001358F43.1112
Epidural anesthesiaD00076711
Show 6 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients314
Breast neoplasmsD001943EFO_0003869C5022
Orthostatic intoleranceD054971212
ObesityD009765EFO_0001073E66.9112
Parkinson diseaseD010300EFO_0002508G20112
AnesthesiaD00075822
Back painD001416HP_0003418M54112
Chronic fatigue syndromeD015673EFO_0004540G93.31112
Conduction anesthesiaD00076511
HerniorrhaphyD05968511
Show 25 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Blood pressureD001794EFO_000432522
Male circumcisionD002944EFO_000395311
Vascular stiffnessD05928911
Neurodegenerative diseasesD019636EFO_0005772G31.911
Autonomic nervous system diseasesD001342EFO_0009532G9011
Orthostatic hypotensionD007024I95.111
Amphetamine-related disordersD019969EFO_0004701F1511
Mood disordersD019964EFO_0004247F30-F3911
Cocaine-related disordersD019970F1411
Heroin dependenceD006556EFO_000424011
Show 1 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PregnancyD011247EFO_0002950Z33.111
Pilonidal sinusD010864HP_0010769L0511
RhytidoplastyD01536111
Asphyxia neonatorumD001238EFO_1000824P8411
Complex regional pain syndromesD020918EFO_100199811
RadiculopathyD011843M54.111
Ventricular tachycardiaD017180I47.211
Intracranial hemorrhagesD020300EFO_0000551I6211
StrokeD020521EFO_0000712I63.911
Cerebral hemorrhageD00254311
Show 7 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCORTICOTROPIN
INNcorticotropin
Description
Corticotropin is a polypeptide hormone produced and secreted by the pituitary gland comprising 39 amino acid residues coupled in a linear sequence. The N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Corticotropin stimulates the cortex of the adrenal gland and boosts the synthesis of corticosteroids, mainly glucocorticoids but also sex steroids (androgens). It is used in the treatment of certain neurological disorders such as infantile spasms and multiple sclerosis, and diagnostically to investigate adrenocortical insufficiency. It has a role as a diagnostic agent. It is a polypeptide, a peptide hormone and a biomacromolecule.
Classification
Protein
Drug classatropine derivatives
Image (chem structure or protein)CORTICOTROPIN
Structure (InChI/SMILES or Protein Sequence)
Identifiers
PDB
CAS-ID9002-60-2
RxCUI376
ChEMBL IDCHEMBL1201610
ChEBI ID
PubChem CID
DrugBankDB01285
UNII IDK0U68Q2TXA (ChemIDplus, GSRS)
Target
Agency Approved
MC2R
MC2R
Organism
Homo sapiens
Gene name
MC2R
Gene synonyms
ACTHR
NCBI Gene ID
Protein name
adrenocorticotropic hormone receptor
Protein synonyms
ACTH receptor, Adrenocorticotropin receptor, corticotropin receptor, MC2 receptor, MC2-R, melanocortin 2 receptor (adrenocorticotropic hormone), Melanocortin receptor 2
Uniprot ID
Mouse ortholog
Mc2r (17200)
adrenocorticotropic hormone receptor (Q64326)
Alternate
LINC02210-CRHR1
LINC02210-CRHR1
MC5R
MC5R
MC4R
MC4R
MC1R
MC1R
MC3R
MC3R
CRHR2
CRHR2
Organism
Homo sapiens
Gene name
LINC02210-CRHR1
Gene synonyms
CRFR, CRFR1, CRHR
NCBI Gene ID
Protein name
CRHR1-IT1-CRHR1 protein
Protein synonyms
Corticotropin-releasing hormone receptor 1, CRH-R-1, CRH-R1, CRHR1-IT1-CRHR1 readthrough
Uniprot ID
Mouse ortholog
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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14,079 adverse events reported
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