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Cocaine
Goprelto, Numbrino (cocaine) is a small molecule pharmaceutical. Cocaine was first approved as Goprelto on 2017-12-14. It is used to treat cough and pain in the USA. The pharmaceutical is active against sodium-dependent dopamine transporter. In addition, it is known to target 5-hydroxytryptamine receptor 3A.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
respiratory tract diseasesD012140
signs and symptoms pathological conditionsD013568
psychological phenomenaD011579
musculoskeletal and neural physiological phenomenaD055687
Trade Name
FDA
EMA
Goprelto, Numbrino
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Cocaine hydrochloride
Tradename
Company
Number
Date
Products
NUMBRINOLannettN-209575 RX2020-01-10
1 products, RLD, RS
GOPRELTOGenus LifesciencesN-209963 RX2017-12-14
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
cocaine hydrochloride nasalNDA authorized generic2023-04-21
gopreltoNew Drug Application2020-01-03
numbrinoNew Drug Application2020-08-04
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
coughHP_0012735D003371R05
painEFO_0003843D010146R52
Agency Specific
FDA
EMA
Expiration
Code
COCAINE HYDROCHLORIDE, NUMBRINO, CODY LABS INC
2023-01-10NP
Patent Expiration
Patent
Expires
Flag
FDA Information
Cocaine Hydrochloride, Goprelto, Genus Lifesciences
98678152037-02-07U-2225, U-2226, U-2227
100164072037-02-07U-2329
101498432037-02-07U-2478, U-2479
102319612037-02-07DP
104135052037-02-07U-2479
104207602037-02-07U-2478
108570952037-02-07U-3014
108940122037-02-07U-3014
109330602037-02-07U-3014
109738112037-02-07U-2226
109873472037-02-07U-2225
110400322037-02-07DP
ATC Codes
N: Nervous system drugs
— N01: Anesthetics
— N01B: Local anesthetics
— N01BC: Esters of benzoic acid for local anesthesia
— N01BC01: Cocaine
R: Respiratory system drugs
— R02: Throat preparations
— R02A: Throat preparations
— R02AD: Local anesthetic throat preparations
— R02AD03: Cocaine
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01H: Local anesthetics, ophthalmologic
— S01HA: Local anesthetics
— S01HA01: Cocaine
— S02: Otologicals
— S02D: Other otologicals in atc
— S02DA: Analgesics and anesthetics
— S02DA02: Cocaine
HCPCS
Code
Description
C9046
Cocaine hydrochloride nasal solution for topical administration, 1 mg
Clinical
Clinical Trials
9 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Staphylococcal infectionsD013203A49.01——1113
OsteomyelitisD010019EFO_0003102M86———1—1
AbscessD000038EFO_0003030———1—1
Infectious arthritisD001170EFO_1001351M00———1—1
Central nervous system infectionsD002494EFO_1001456A81———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
EndocarditisD004696EFO_0000465I33——1——1
StaphylococcusD013210——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Gram-positive bacterial infectionsD016908—1———1
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
InfectionsD007239EFO_0000544————22
Renal dialysisD006435EFO_0010690Z99.2————11
NeutropeniaD009503D70————11
NeoplasmsD009369C80————11
FeverD005334HP_0001945R50.9————11
BacteremiaD016470EFO_0003033R78.81————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCOCAINE
INN—
Description
Cocaine is a tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca. It has a role as a local anaesthetic, a central nervous system stimulant, a sodium channel blocker, an adrenergic uptake inhibitor, a dopamine uptake inhibitor, a serotonin uptake inhibitor, a sympathomimetic agent, a vasoconstrictor agent, a xenobiotic, an environmental contaminant, a plant metabolite and a mouse metabolite. It is a methyl ester, a benzoate ester, a tertiary amino compound and a tropane alkaloid. It is a conjugate base of a cocaine(1+).
Classification
Small molecule
Drug classlocal anesthetics
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C
Identifiers
PDB2PGZ
CAS-ID50-36-2
RxCUI2653
ChEMBL IDCHEMBL370805
ChEBI ID27958
PubChem CID446220
DrugBankDB00907
UNII ID—
Target
Agency Approved
SLC6A3
SLC6A3
Organism
Homo sapiens
Gene name
SLC6A3
Gene synonyms
DAT1
NCBI Gene ID
6531
Protein name
sodium-dependent dopamine transporter
Protein synonyms
DA transporter, dopamine transporter 1, solute carrier family 6 (neurotransmitter transporter), member 3, solute carrier family 6 (neurotransmitter transporter, dopamine), member 3, Solute carrier family 6 member 3
Uniprot ID
Q14996
Mouse ortholog
Slc6a3 (13162)
sodium-dependent dopamine transporter (Q9R1I2)
Alternate
HTR3A
HTR3A
Organism
Homo sapiens
Gene name
HTR3A
Gene synonyms
5HT3R, HTR3
NCBI Gene ID
3359
Protein name
5-hydroxytryptamine receptor 3A
Protein synonyms
5-HT-3, 5-HT3R, 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic, 5-hydroxytryptamine receptor 3, 5HT3 serotonin receptor, Serotonin receptor 3A, Serotonin-gated ion channel receptor
Uniprot ID
Q9BSZ9
Mouse ortholog
Htr3a (15561)
5-hydroxytryptamine receptor 3A (Q61226)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 111,021 documents
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Safety
Black-box Warning
Black-box warning for: Cocaine hydrochloride nasal, Goprelto, Numbrino
Adverse Events
Top Adverse Reactions
Mock data
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2,567 adverse events reported
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