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Clioquinol
Nystaform (clioquinol) is a small molecule pharmaceutical. Clioquinol was first approved as Nystaform on 1982-01-01. It is used to treat acneiform eruptions, dermatitis, folliculitis, lichenoid eruptions, and tinea pedis in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
skin and connective tissue diseasesD017437
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Clioquinol
+
Nystatin
Tradename
Company
Number
Date
Products
NYSTAFORMBayerN-050235 DISCN1982-01-01
1 products
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Labels
FDA
EMA
Brand Name
Status
Last Update
dermoscribe ichybumOTC monograph not final2019-03-04
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
acneiform eruptionsEFO_1000662D017486
dermatitisHP_0011123D003872L30.9
folliculitisD005499
lichenoid eruptionsD017512
tinea pedisEFO_0007512D014008B35.3
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
D: Dermatologicals
D08: Antiseptics and disinfectants
D08A: Antiseptics and disinfectants
D08AH: Quinoline derivatives, antiseptics and disinfectants
D08AH30: Clioquinol
D09: Medicated dressings
D09A: Medicated dressings
D09AA: Medicated dressings with antiinfectives
D09AA10: Clioquinol
G: Genito urinary system and sex hormones
G01: Gynecological antiinfectives and antiseptics
G01A: Antiinfectives and antiseptics, excl. combinations with corticosteroids
G01AC: Quinoline gynecological antiinfectives
G01AC02: Clioquinol
P: Antiparasitic products, insecticides and repellents
P01: Antiprotozoals
P01A: Agents against amoebiasis and other protozoal diseases
P01AA: Hydroxyquinoline derivatives for amoebiasis and other protozoal diseases
P01AA02: Clioquinol
P01AA52: Clioquinol, combinations
S: Sensory organ drugs
S02: Otologicals
S02A: Antiinfective drugs, otologic
S02AA: Antiinfectives
S02AA05: Clioquinol
HCPCS
No data
Clinical
Clinical Trials
1 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Chest painD002637HP_0100749R07.911
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCLIOQUINOL
INNclioquinol
Description
5-chloro-7-iodoquinolin-8-ol is a monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease. It has a role as an antifungal agent, an antineoplastic agent, an antimicrobial agent, an antibacterial agent, a chelator, an antiprotozoal drug and a copper chelator. It is an organochlorine compound, an organoiodine compound and a monohydroxyquinoline.
Classification
Small molecule
Drug class
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Oc1c(I)cc(Cl)c2cccnc12
Identifiers
PDB
CAS-ID130-26-7
RxCUI5942
ChEMBL IDCHEMBL497
ChEBI ID74460
PubChem CID2788
DrugBankDB04815
UNII ID7BHQ856EJ5 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,938 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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29,690 adverse events reported
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