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Clidinium
Librax, Quarzan (clidinium) is a small molecule pharmaceutical. Clidinium was first approved as Librax on 1982-01-01. It is used to treat inflammatory bowel diseases and peptic ulcer in the USA. The pharmaceutical is active against muscarinic acetylcholine receptor M3. In addition, it is known to target muscarinic acetylcholine receptor M2.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
digestive system diseasesD004066
Trade Name
FDA
EMA
Combinations
Librax (generic drugs available since 2020-07-07)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Chlordiazepoxide hydrochloride
+
Clidinium bromide
Tradename
Company
Number
Date
Products
LIBRAXBausch Health CompaniesN-012750 RX1982-01-01
1 products, RLD, RS
Clidinium bromide
Tradename
Company
Number
Date
Products
QUARZANRocheN-010355 DISCN1982-01-01
2 products
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Labels
FDA
EMA
Brand Name
Status
Last Update
chlordiazepoxide hcl and clidinium bromide ANDA2023-04-26
libraxNew Drug Application2021-02-03
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
inflammatory bowel diseasesEFO_0003767D015212—
peptic ulcerHP_0004398D010437K27
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A03: Drugs for functional gastrointestinal disorders
— A03C: Antispasmodics in combination with psycholeptics
— A03CA: Synthetic anticholinergic agents in combination with psycholeptics
— A03CA02: Clidinium and psycholeptics
HCPCS
No data
Clinical
Clinical Trials
14 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Multiple sclerosisD009103EFO_0003885G35231——4
DermatitisD003872HP_0011123L30.9——2——2
HypersensitivityD006967EFO_0003785T78.401—1——2
Ocular motility disordersD015835EFO_1001990H50.54——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Relapsing-remitting multiple sclerosisD020529EFO_000392912———2
AngioedemaD000799EFO_0005532T78.3—1———1
Chronic urticariaD000080223L50.8—1———1
Optic neuritisD009902EFO_0007405H46—1———1
Chronic progressive multiple sclerosisD02052811———1
SclerosisD01259811———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—1————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCLIDINIUM
INNclidinium bromide
Description
Clidinium is the ester resulting from formal condensation of benzilic acid and 3-hydroxy-1-methyl-1-azoniabicyclo[2.2.2]octane. It is used, generally as the bromide, for the symptomatic treatment of peptic ulcer disease and also to help relieve abdominal or stomach spasms or cramps due to colicky abdominal pain, diverticulitis, and irritable bowel syndrome. It has a role as a parasympatholytic, an antispasmodic drug and an anti-arrhythmia drug. It is a quaternary ammonium ion, a carboxylic ester and an organic cation. It is functionally related to a benzilic acid and a 3-quinuclidinol.
Classification
Small molecule
Drug classquaternary ammonium derivatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
C[N+]12CCC(CC1)C(OC(=O)C(O)(c1ccccc1)c1ccccc1)C2
Identifiers
PDB—
CAS-ID7020-55-5
RxCUI21232
ChEMBL IDCHEMBL620
ChEBI ID—
PubChem CID2784
DrugBankDB00771
UNII ID91ZQW5JF1Z (ChemIDplus, GSRS)
Target
Agency Approved
CHRM3
CHRM3
Organism
Homo sapiens
Gene name
CHRM3
Gene synonyms
NCBI Gene ID
1131
Protein name
muscarinic acetylcholine receptor M3
Protein synonyms
acetylcholine receptor, muscarinic 3, m3 muscarinic receptor
Uniprot ID
Q9HB60
Mouse ortholog
Chrm3 (12671)
muscarinic acetylcholine receptor M3 (Q9ERZ3)
Alternate
CHRM2
CHRM2
Organism
Homo sapiens
Gene name
CHRM2
Gene synonyms
NCBI Gene ID
1129
Protein name
muscarinic acetylcholine receptor M2
Protein synonyms
7TM receptor, acetylcholine receptor, muscarinic 2, muscarinic M2 receptor
Uniprot ID
Q9P1X9
Mouse ortholog
Chrm2 (243764)
muscarinic acetylcholine receptor M2 (Q9ERZ4)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 181 documents
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Safety
Black-box Warning
Black-box warning for: Chlordiazepoxide hcl and clidinium bromide , Librax
Adverse Events
Top Adverse Reactions
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670 adverse events reported
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