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Cisapride
Propulsid (cisapride) is a small molecule pharmaceutical. Cisapride was first approved as Propulsid on 1993-07-29. It is used to treat constipation, dyspepsia, gastroesophageal reflux, and gastroparesis in the USA. The pharmaceutical is active against 5-hydroxytryptamine receptor 4. In addition, it is known to target 5-hydroxytryptamine receptor 7 and potassium voltage-gated channel subfamily H member 2.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
digestive system diseasesD004066
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Cisapride monohydrate
Tradename
Company
Number
Date
Products
PROPULSID QUICKSOLVJohnson & JohnsonN-020767 DISCN1997-11-07
1 products
PROPULSIDJohnson & JohnsonN-020210 DISCN1993-07-29
2 products
PROPULSIDJohnson & JohnsonN-020398 DISCN1995-09-15
1 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
constipationHP_0002019D003248K59.0
dyspepsiaEFO_0008533D004415K30
gastroesophageal refluxEFO_0003948D005764K21
gastroparesisEFO_1000948D018589K31.84
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
A03: Drugs for functional gastrointestinal disorders
A03F: Propulsives
A03FA: Propulsives
A03FA02: Cisapride
HCPCS
No data
Clinical
Clinical Trials
177 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
InfertilityD007246EFO_0000545358211450
Fertilization in vitroD0053071227516
Polycystic ovary syndromeD011085EFO_0000660E28.21243210
Female infertilityD007247EFO_0008560N971113510
HypogonadismD007006E23.0111317
Kallmann syndromeD017436Orphanet_478E23.0426
Intracytoplasmic sperm injectionsD02055444
Embryo transferD0046241124
Ovarian hyperstimulation syndromeD016471123
FertilityD005298112
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PregnancyD011247EFO_0002950Z33.11235
Klinefelter syndromeD007713EFO_1001006Q98.0112
Covid-19D000086382U07.1112
AnovulationD00085811
Assisted reproductive techniquesD02772411
Embryonic developmentD04710811
Adenomatous polypsD018256D28111
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Ovulation inductionD010062235
LeiomyomaD007889HP_0000131D251112
Primary ovarian insufficiencyD016649EFO_0004266E28.31112
SinusitisD012852EFO_0007486J3211
InfectionsD007239EFO_0000544111
EndometriosisD004715EFO_0001065N80111
Ectopic pregnancyD011271O00111
SalpingitisD012488N70.91111
Graft vs host diseaseD006086D89.81111
Endocrine system diseasesD004700EFO_0001379E34.9111
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369C8011
NeuroblastomaD009447EFO_000062111
Retinal diseasesD012164HP_0000479H35.911
Healthy volunteers/patients11
AzoospermiaD053713EFO_0000279N46.011
NeurodermatitisD009450L28.011
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Pregnancy testsD01125844
Pregnancy rateD01887322
HivD006678O98.722
AsthmaD001249EFO_0000270J4522
Reproductive behaviorD04376211
Premature obstetric laborD007752O6011
EunuchismD005058EFO_0007266E29.111
Breast neoplasmsD001943EFO_0003869C5011
Spinal cord injuriesD013119EFO_100191911
SpondylarthritisD02524111
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCISAPRIDE
INNcisapride
Description
Cisapride is the amide resulting from formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with cis-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-amine. It has been used (as its monohydrate or as its tartrate) for the treatment of gastro-oesophageal reflux disease and for non-ulcer dyspepsia, but its propensity to cause cardiac arrhythmias resulted in its complete withdrawal from many countries, including the U.K., and restrictions on its use elsewhere. It has a role as a serotonergic agonist, an anti-ulcer drug and a gastrointestinal drug. It is a member of piperidines, a member of benzamides, a member of monochlorobenzenes, a substituted aniline, an organofluorine compound and an aromatic ether.
Classification
Small molecule
Drug classsulpride derivatives and analogs
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCOc2ccc(F)cc2)CC1OC
Identifiers
PDB
CAS-ID81098-60-4
RxCUI35255
ChEMBL IDCHEMBL1729
ChEBI ID
PubChem CID6917698
DrugBankDB00604
UNII IDUVL329170W (ChemIDplus, GSRS)
Target
Agency Approved
HTR4
HTR4
Organism
Homo sapiens
Gene name
HTR4
Gene synonyms
NCBI Gene ID
Protein name
5-hydroxytryptamine receptor 4
Protein synonyms
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled, cardiac 5-HT4 receptor, Serotonin receptor 4
Uniprot ID
Mouse ortholog
Htr4 (15562)
5-hydroxytryptamine receptor 4 (Q9R2A4)
Alternate
HTR7
HTR7
KCNH2
KCNH2
Organism
Homo sapiens
Gene name
HTR7
Gene synonyms
NCBI Gene ID
Protein name
5-hydroxytryptamine receptor 7
Protein synonyms
5-HT-7, 5-HT-X, 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled), Serotonin receptor 7
Uniprot ID
Mouse ortholog
Htr7 (15566)
5-hydroxytryptamine receptor 7 (Q14A50)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 3,785 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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181 adverse events reported
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