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Cimetidine
Tagamet (cimetidine) is a small molecule pharmaceutical. Cimetidine was first approved as Tagamet on 1982-01-01. It is used to treat duodenal ulcer, dyspepsia, gastroesophageal reflux, heartburn, and helicobacter infections amongst others in the USA. The pharmaceutical is active against histamine H2 receptor. In addition, it is known to target multidrug and toxin extrusion protein 2, multidrug and toxin extrusion protein 1, and equilibrative nucleoside transporter 4.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
neoplasmsD009369
digestive system diseasesD004066
skin and connective tissue diseasesD017437
immune system diseasesD007154
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Tagamet (generic drugs available since 1994-05-17, discontinued: Tagamet)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Cimetidine
Tradename
Company
Number
Date
Products
TAGAMET HBMedTech ProductsN-020238 OTC1996-08-21
1 products, RLD, RS
Show 3 discontinued
Cimetidine hydrochloride
Tradename
Company
Number
Date
Products
TAGAMETGSKN-017924 DISCN1982-01-01
1 products
TAGAMETGSKN-017939 DISCN1982-01-01
1 products
TAGAMET HYDROCHLORIDE IN SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINERGSKN-019434 DISCN1985-10-31
1 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
tagametNew Drug Application2023-05-09
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
duodenal ulcerEFO_0004607D004381K26
dyspepsiaEFO_0008533D004415K30
gastroesophageal refluxEFO_0003948D005764K21
heartburn—D006356R12
helicobacter infectionsEFO_1000961D016481—
peptic esophagitisEFO_1001095D004942—
stomach ulcer—D013276K25
urticariaEFO_0005531D014581L50
zollinger-ellison syndrome—D015043E16.4
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A02: Drugs for acid related disorders
— A02B: Drugs for peptic ulcer and gastro-oesophageal reflux disease (gord)
— A02BA: H2-receptor antagonists
— A02BA01: Cimetidine
— A02BA51: Cimetidine, combinations
HCPCS
Code
Description
S0023
Injection, cimetidine hydrochloride, 300 mg
Clinical
Clinical Trials
50 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—6——1—7
OsteoarthritisD010003EFO_0002506M15-M19———145
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Peptic ulcerD010437HP_0004398K27——1——1
Atopic dermatitisD003876EFO_0000274L20——1——1
Breast neoplasmsD001943EFO_0003869C50—11——1
Femoral neck fracturesD005265EFO_1001792S72.00——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hip osteoarthritisD015207EFO_1000786M16—1——12
Endometrial neoplasmsD016889EFO_0004230—1———1
NeoplasmsD009369C80—1———1
MelanomaD008545—1———1
Kidney neoplasmsD007680EFO_0003865C64—1———1
Erythropoietic protoporphyriaD046351E80.0—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Chronic obstructive pulmonary diseaseD029424EFO_0000341J44.91————1
Bacterial infectionsD001424A491————1
Amyotrophic lateral sclerosisD000690EFO_0000253G12.211————1
Anxiety disordersD001008EFO_0006788F41.11————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Replacement arthroplasty kneeD019645————44
Rheumatoid arthritisD001172EFO_0000685M06.9————33
Knee osteoarthritisD020370EFO_0004616M17————33
OsteonecrosisD010020EFO_0004259M87————22
Gastroesophageal refluxD005764EFO_0003948K21————11
ArthritisD001168EFO_0005856M05-M14————11
Hip fracturesD006620EFO_0003964S72.00————11
Bone fracturesD050723EFO_0003931T14.8————11
Multiple fracturesD000069076HP_0002757————11
Shoulder painD020069HP_0030834M25.51————11
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCIMETIDINE
INNcimetidine
Description
Cimetidine is a member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach. It has a role as a H2-receptor antagonist, a P450 inhibitor, an anti-ulcer drug, an analgesic and an adjuvant. It is a member of guanidines, a member of imidazoles, an aliphatic sulfide and a nitrile.
Classification
Small molecule
Drug classH2-receptor antagonists (cimetidine type)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CN/C(=N\CCSCc1nc[nH]c1C)NC#N
Identifiers
PDB—
CAS-ID51481-61-9
RxCUI2541
ChEMBL IDCHEMBL30
ChEBI ID3699
PubChem CID2756
DrugBankDB00501
UNII ID80061L1WGD (ChemIDplus, GSRS)
Target
Agency Approved
HRH2
HRH2
Organism
Homo sapiens
Gene name
HRH2
Gene synonyms
NCBI Gene ID
3274
Protein name
histamine H2 receptor
Protein synonyms
gastric receptor 1, Gastric receptor I
Uniprot ID
P25021
Mouse ortholog
Hrh2 (15466)
histamine H2 receptor (Q9D282)
Alternate
SLC47A2
SLC47A2
SLC47A1
SLC47A1
SLC29A4
SLC29A4
Organism
Homo sapiens
Gene name
SLC47A2
Gene synonyms
MATE2
NCBI Gene ID
146802
Protein name
multidrug and toxin extrusion protein 2
Protein synonyms
Kidney-specific H(+)/organic cation antiporter, solute carrier family 47 (multidrug and toxin extrusion), member 2, Solute carrier family 47 member 2
Uniprot ID
Q86VL8
Mouse ortholog
—
—
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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41,585 adverse events reported
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