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Chlorthalidone
Clorpres, Combipres, Demi-regroton, Edarbyclor, Kerledex, Lopressidone, Regroton, Tenoretic, Thalitone (chlorthalidone) is a small molecule pharmaceutical. Chlorthalidone was first approved as Hygroton on 1982-01-01. It is used to treat edema, glomerulonephritis, heart failure, hypertension, and liver cirrhosis amongst others in the USA. The pharmaceutical is active against carbonic anhydrase 7. In addition, it is known to target carbonic anhydrase 12, carbonic anhydrase 14, carbonic anhydrase 1, carbonic anhydrase 4, and carbonic anhydrase 2.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
digestive system diseasesD004066
urogenital diseasesD000091642
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Thalitone (generic drugs available since 1982-01-01, discontinued: Hygroton)
Combinations
Edarbyclor, Tenoretic (generic drugs available since 1982-01-01, discontinued: Clorpres, Combipres, Demi-regroton, Kerledex, Lopressidone, Regroton)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Atenolol
+
Chlorthalidone
Tradename
Company
Number
Date
Products
TENORETIC 100Almatica PharmaN-018760 RX1984-06-08
1 products, RLD, RS
TENORETIC 50Almatica PharmaN-018760 RX1984-06-08
1 products, RLD
Azilsartan kamedoxomil
+
Chlorthalidone
Tradename
Company
Number
Date
Products
EDARBYCLORAzurityN-202331 RX2011-12-20
2 products, RLD, RS
Betaxolol hydrochloride
+
Chlorthalidone
Tradename
Company
Number
Date
Products
KERLEDEXSanofiN-019807 DISCN1992-10-30
2 products
Hide discontinued
Chlorthalidone
Tradename
Company
Number
Date
Products
THALITONECasper PharmaN-019574 RX1988-12-20
2 products, RLD
Show 1 discontinued
Chlorthalidone
+
Clonidine hydrochloride
Tradename
Company
Number
Date
Products
COMBIPRESBoehringer IngelheimN-017503 DISCN1982-01-01
3 products, RLD
Hide discontinued
Chlorthalidone
+
Metoprolol tartrate
Tradename
Company
Number
Date
Products
LOPRESSIDONENovartisN-019451 DISCN1987-12-31
2 products
Hide discontinued
Chlorthalidone
+
Reserpine
Tradename
Company
Number
Date
Products
REGROTONSanofiN-015103 DISCN1982-01-01
1 products
DEMI-REGROTONSanofiN-015103 DISCN1982-01-01
1 products
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
chlorthalidoneANDA2023-06-07
edarbyclorNew Drug Application2020-06-05
tenoreticNew Drug Application2021-01-31
thalitoneNew Drug Application2019-12-30
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
edema—D004487R60.9
glomerulonephritis—D005921N05
heart failureEFO_0003144D006333I50
hypertensionEFO_0000537D006973I10
liver cirrhosisEFO_0001422D008103K74.0
nephrotic syndromeEFO_0004255D009404N04
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Azilsartan Kamedoxomil / Chlorthalidone, Edarbyclor, Azurity
93872492031-07-01U-3
91692382030-02-04DP
90669362028-03-26DP
71575842025-05-22DP
75729202025-01-07DPU-3
ATC Codes
C: Cardiovascular system drugs
— C03: Diuretics
— C03B: Low-ceiling diuretics, excl. thiazides
— C03BA: Sulfonamides, low-ceiling diuretics, plain
— C03BA04: Chlortalidone
— C03BB: Sulfonamides and potassium in combination, low-ceiling diruetics, excluding thiazides
— C03BB04: Chlortalidone and potassium
— C03E: Diuretics and potassium-sparing agents in combination
— C03EA: Low-ceiling diuretics and potassium-sparing agents
— C03EA06: Chlortalidone and potassium-sparing agents
HCPCS
No data
Clinical
Clinical Trials
2 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
DementiaD003704F03——1——1
Psychophysiologic disordersD011602F45.9——1——1
SchizophreniaD012559EFO_0000692F20——1——1
DepressionD003863F33.9——1——1
Anxiety disordersD001008EFO_0006788F41.1——1——1
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Morbid obesityD009767EFO_0001074————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCHLORTHALIDONE
INNchlortalidone
Description
Chlorthalidone is a sulfonamide, a member of isoindoles and a member of monochlorobenzenes.
Classification
Small molecule
Drug classThiazide-like diuretic
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
NS(=O)(=O)c1cc(C2(O)NC(=O)c3ccccc32)ccc1Cl
Identifiers
PDB3F4X
CAS-ID77-36-1
RxCUI2409
ChEMBL IDCHEMBL1055
ChEBI ID3654
PubChem CID2732
DrugBankDB00310
UNII IDQ0MQD1073Q (ChemIDplus, GSRS)
Target
Agency Approved
CA7
CA7
Organism
Homo sapiens
Gene name
CA7
Gene synonyms
NCBI Gene ID
766
Protein name
carbonic anhydrase 7
Protein synonyms
CA-VII, Carbonate dehydratase VII, Carbonic anhydrase VII, carbonic dehydratase VII
Uniprot ID
P43166
Mouse ortholog
Car7 (12354)
carbonic anhydrase 7 (Q9ERQ8)
Alternate
CA12
CA12
CA14
CA14
CA1
CA1
CA4
CA4
CA2
CA2
Organism
Homo sapiens
Gene name
CA12
Gene synonyms
NCBI Gene ID
771
Protein name
carbonic anhydrase 12
Protein synonyms
CA-XII, Carbonate dehydratase XII, Carbonic anhydrase XII, carbonic dehydratase, Tumor antigen HOM-RCC-3.1.3
Uniprot ID
Q9BWG2
Mouse ortholog
Car12 (76459)
carbonic anhydrase 12 (Q8CI85)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 3,348 documents
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Safety
Black-box Warning
Black-box warning for: Edarbyclor
Adverse Events
Top Adverse Reactions
Mock data
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582 adverse events reported
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