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Carbachol
Miostat (carbachol) is a small molecule pharmaceutical. Carbachol was first approved as Miostat on 1982-01-01. It is used to treat glaucoma in the USA. The pharmaceutical is active against muscarinic acetylcholine receptor M3. In addition, it is known to target muscarinic acetylcholine receptor M2, muscarinic acetylcholine receptor M5, muscarinic acetylcholine receptor M1, and muscarinic acetylcholine receptor M4.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
eye diseasesD005128
Trade Name
FDA
EMA
Miostat (discontinued: Carbastat)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Carbachol
Tradename
Company
Number
Date
Products
MIOSTATAlcon ResearchN-016968 RX1982-01-01
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
miostat New Drug Application2020-11-09
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
glaucomaEFO_0000516D005901H40
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
N07: Other nervous system drugs in atc
N07A: Parasympathomimetics
N07AB: Choline esters, parasympathomimetics
N07AB01: Carbachol
S: Sensory organ drugs
S01: Ophthalmologicals
S01E: Antiglaucoma preparations and miotics
S01EB: Parasympathomimetics, antiglaucoma preparations and miotics
S01EB02: Carbachol
HCPCS
No data
Clinical
Clinical Trials
135 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Chronic renal insufficiencyD051436N18127212
PsoriasisD011565EFO_0000676L401216212
Secondary hyperparathyroidismD006962EFO_1001173115310
Vitamin d deficiencyD014808EFO_0003762E5511259
Chronic kidney failureD007676EFO_0003884N18.62237
Diabetic nephropathiesD003928EFO_000040112114
OsteoporosisD010024EFO_0003882M81.01113
ProteinuriaD011507HP_0000093R8033
Iga glomerulonephritisD005922EFO_0004194112
Postmenopausal osteoporosisD015663EFO_0003854112
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Prostatic neoplasmsD011471C613102114
HypocalcemiaD006996HP_0002901E83.513126
Adenomatous polypsD018256D2811
AngiofibromaD018322EFO_100176111
Heart transplantationD016027EFO_001067311
OsteopetrosisD010022Q78.211
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Breast neoplasmsD001943EFO_0003869C501214
HypertensionD006973EFO_0000537I101113
Non-small-cell lung carcinomaD002289233
Castration-resistant prostatic neoplasmsD06412922
Pancreatic neoplasmsD010190EFO_0003860C2522
Crohn diseaseD003424EFO_0000384K501112
Myelodysplastic syndromesD009190D4622
HypoparathyroidismD007011E20112
Chronic kidney disease-mineral and bone disorderD012080EFO_1001152N25.022
Type 1 diabetes mellitusD003922EFO_0001359E1022
Show 14 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369C8066
Healthy volunteers/patients11
Cocaine-related disordersD019970F1411
Hypophosphatemic ricketsD063730E83.3111
Chronic diseaseD00290811
Ovarian neoplasmsD010051EFO_0003893C5611
Endometrial neoplasmsD016889EFO_000423011
Uterine cervical neoplasmsD00258311
Central nervous system neoplasmsD01654311
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Open-angle glaucomaD005902EFO_0004190H40.122
Rheumatoid arthritisD001172EFO_0000685M06.911
Kidney diseasesD007674EFO_0003086N0811
HyperparathyroidismD006961EFO_0008506E21.311
Thyroid diseasesD013959HP_0000820E00-E0711
ObesityD009765EFO_0001073E66.911
Type 2 diabetes mellitusD003924EFO_0001360E1111
Lung neoplasmsD008175C34.9011
Tobacco use disorderD014029F1711
Precancerous conditionsD01123011
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCARBACHOL
INNcarbachol
Description
Carbachol is an ammonium salt and a carbamate ester. It has a role as a nicotinic acetylcholine receptor agonist, a muscarinic agonist, a non-narcotic analgesic, a cardiotonic drug and a miotic.
Classification
Small molecule
Drug class
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
C[N+](C)(C)CCOC(N)=O.[Cl-]
Identifiers
PDB
CAS-ID51-83-2
RxCUI1999
ChEMBL IDCHEMBL14
ChEBI ID3385
PubChem CID5831
DrugBankDB00411
UNII ID8Y164V895Y (ChemIDplus, GSRS)
Target
Agency Approved
CHRM3
CHRM3
Organism
Homo sapiens
Gene name
CHRM3
Gene synonyms
NCBI Gene ID
Protein name
muscarinic acetylcholine receptor M3
Protein synonyms
acetylcholine receptor, muscarinic 3, m3 muscarinic receptor
Uniprot ID
Mouse ortholog
Chrm3 (12671)
muscarinic acetylcholine receptor M3 (Q9ERZ3)
Alternate
CHRM2
CHRM2
CHRM5
CHRM5
CHRM1
CHRM1
CHRM4
CHRM4
Organism
Homo sapiens
Gene name
CHRM2
Gene synonyms
NCBI Gene ID
Protein name
muscarinic acetylcholine receptor M2
Protein synonyms
7TM receptor, acetylcholine receptor, muscarinic 2, muscarinic M2 receptor
Uniprot ID
Mouse ortholog
Chrm2 (243764)
muscarinic acetylcholine receptor M2 (Q9ERZ4)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 15,254 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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2,125 adverse events reported
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