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Qutenza(capsaicin)
Qutenza (capsaicin) is a small molecule pharmaceutical. Capsaicin was first approved as Qutenza on 2009-05-15. It is used to treat diabetic neuropathies, herpes zoster, and neuralgia in the USA. It has been approved in Europe to treat neuralgia. The pharmaceutical is active against transient receptor potential cation channel subfamily V member 1. In addition, it is known to target cystic fibrosis transmembrane conductance regulator, transient receptor potential cation channel subfamily V member 6, potassium voltage-gated channel subfamily C member 1, potassium voltage-gated channel subfamily A member 7, potassium voltage-gated channel subfamily A member 2, and potassium voltage-gated channel subfamily A member 1.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
nervous system diseasesD009422
endocrine system diseasesD004700
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Qutenza
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Capsaicin
Tradename
Company
Number
Date
Products
QUTENZAAveritas PharmaN-022395 RX2009-11-16
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
leader capsaicin pain relief creamOTC monograph not final2023-06-08
qutenzaNew Drug Application2020-10-21
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
diabetic neuropathiesEFO_1000783D003929
herpes zosterEFO_0006510D006562B02
neuralgiaEFO_0009430D009437
Agency Specific
FDA
EMA
Expiration
Code
CAPSAICIN, QUTENZA, AVERITAS
2023-07-17I-838
Patent Expiration
Patent
Expires
Flag
FDA Information
Capsaicin, Qutenza, Averitas
88219202030-03-26DP
92269032028-12-15DP
100348412025-09-06DP
82630592023-09-05U-2705
88891132023-09-05U-2705
104635982023-09-05DP
108698272023-09-05DP
ATC Codes
M: Musculo-skeletal system drugs
M02: Topical products for joint and muscular pain
M02A: Topical products for joint and muscular pain
M02AB: Capsaicin and similar agents
M02AB01: Capsaicin
N: Nervous system drugs
N01: Anesthetics
N01B: Local anesthetics
N01BX: Other local anesthetics in atc
N01BX04: Capsaicin
HCPCS
Code
Description
J7336
Capsaicin 8% patch, per square centimeter
Clinical
Clinical Trials
177 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PainD010146EFO_0003843R5269101530
NeuralgiaD009437EFO_00094301642719
Healthy volunteers/patients631514
Diabetic neuropathiesD003929EFO_100078346210
Knee osteoarthritisD020370EFO_0004616M17213118
Postherpetic neuralgiaD0514741336
Peripheral nerve injuriesD0593481123
ExerciseD015444EFO_0000483112
Central nervous system sensitizationD059333112
Motor disordersD00006807911
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Peripheral nervous system diseasesD010523G6457112
Herpes zosterD006562EFO_0006510B02548
Hiv infectionsD015658EFO_0000764B20437
Breast neoplasmsD001943EFO_0003869C50112
Head and neck neoplasmsD006258112
Acute painD059787R52112
OsteoarthritisD010003EFO_0002506M15-M19112
VulvodyniaD056650N94.81111
DyslipidemiasD050171HP_0003119111
OverweightD050177E66.3111
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
CoughD003371HP_0012735R054248
Deglutition disordersD003680HP_0002015R13.1156
PruritusD011537HP_0000989L291123
Parkinson diseaseD010300EFO_0002508G202113
Pulmonary hypertensionD006976EFO_0001361I27.2022
Myofascial pain syndromesD009209EFO_1001054112
Postoperative painD010149G89.1822
Diabetes mellitusD003920EFO_0000400E08-E1322
PolyneuropathiesD011115EFO_0009562A69.2222
Morton neuromaD000070607G57.622
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
StrokeD020521EFO_0000712I63.9134
Migraine disordersD008881EFO_0003821G43213
Amyotrophic lateral sclerosisD000690EFO_0000253G12.21213
MetabolismD008660GO_000815222
Sickle cell anemiaD000755EFO_0000697D5711
Cluster headacheD003027HP_0012199G44.0011
Trigeminal autonomic cephalalgiasD05130311
Paroxysmal hemicraniaD051302EFO_1001822G44.0311
CystinosisD003554E72.0411
Brain injuriesD001930S06.911
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Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HyperalgesiaD00693022
Chest painD002637HP_0100749R07.922
Burning mouth syndromeD002054EFO_100085022
HeadacheD006261HP_0002315R5111
ArthritisD001168EFO_0005856M05-M1411
TendinopathyD052256EFO_1001434M77.911
SynovitisD013585EFO_0008997M67.511
SpasmD013035M62.8311
RadiculopathyD011843M54.111
GoutD006073EFO_0004274M1011
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCAPSAICIN
INNcapsaicin
Description
Capsaicin is a capsaicinoid. It has a role as a non-narcotic analgesic, a voltage-gated sodium channel blocker and a TRPV1 agonist.
Classification
Small molecule
Drug class
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COc1cc(CNC(=O)CCCC/C=C/C(C)C)ccc1O
Identifiers
PDB7VEK
CAS-ID404-86-4
RxCUI1992
ChEMBL IDCHEMBL294199
ChEBI ID3374
PubChem CID1548943
DrugBankDB06774
UNII IDS07O44R1ZM (ChemIDplus, GSRS)
Target
Agency Approved
TRPV1
TRPV1
Organism
Homo sapiens
Gene name
TRPV1
Gene synonyms
VR1
NCBI Gene ID
Protein name
transient receptor potential cation channel subfamily V member 1
Protein synonyms
Capsaicin receptor, Osm-9-like TRP channel 1, OTRPC1, transient receptor potential vanilloid 1a, transient receptor potential vanilloid 1b, Vanilloid receptor 1, vanilloid receptor subtype 1
Uniprot ID
Mouse ortholog
Trpv1 (193034)
transient receptor potential cation channel subfamily V member 1 (Q704Y3)
Alternate
CFTR
CFTR
TRPV6
TRPV6
KCNC1
KCNC1
KCNA7
KCNA7
KCNA2
KCNA2
KCNA1
KCNA1
Organism
Homo sapiens
Gene name
CFTR
Gene synonyms
ABCC7
NCBI Gene ID
Protein name
cystic fibrosis transmembrane conductance regulator
Protein synonyms
ATP-binding cassette sub-family C member 7, cAMP-dependent chloride channel, Channel conductance-controlling ATPase, cystic fibrosis transmembrane conductance regulating, cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
Uniprot ID
Mouse ortholog
Cftr (12638)
cystic fibrosis transmembrane conductance regulator (Q9JKQ6)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 30,449 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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240 adverse events reported
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