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Betrixaban
Bevyxxa (betrixaban) is a small molecule pharmaceutical. Betrixaban was first approved as Bevyxxa on 2017-06-23. The pharmaceutical is active against coagulation factor X.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Betrixaban
Tradename
Company
Number
Date
Products
BEVYXXAPortola PharmaceuticalsN-208383 DISCN2017-06-23
2 products, RLD
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
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FDA Information
Betrixaban, Bevyxxa, Portola Pharms Inc
84047242031-03-29DPU-2034
89874632030-12-28DP
85578522028-09-08U-1167, U-2030
75982762026-11-08DP
95550232026-11-07U-1502
ATC Codes
B: Blood and blood forming organ drugs
B01: Antithrombotic agents
B01A: Antithrombotic agents
B01AF: Direct factor xa inhibitors
B01AF04: Betrixaban
HCPCS
No data
Clinical
Clinical Trials
217 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PsoriasisD011565EFO_0000676L4020161720878
Atopic dermatitisD003876EFO_0000274L20112228
Premature birthD047928EFO_0003917O6011416
Respiratory distress syndromeD012128EFO_1000637J8013115
Oral lichen planusD0176762114
OsteoarthritisD010003EFO_0002506M15-M19213
Premature obstetric laborD007752O60213
Neck painD019547HP_0030833M54.21113
Back painD001416HP_0003418M54213
Knee osteoarthritisD020370EFO_0004616M1733
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Newborn respiratory distress syndromeD012127P222113
Allergic rhinitisD065631J30.922
PregnancyD011247EFO_0002950Z33.1112
Allergic contact dermatitisD017449L231112
BronchiolitisD001988HP_0011950111
Contact dermatitisD003877L2511
Seborrheic dermatitisD012628L2111
Obstetric labor complicationsD00774411
Oral submucous fibrosisD009914K13.511
CoughD003371HP_0012735R0511
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Dry eye syndromesD015352H04.1222
Rotator cuff injuriesD000070636M75.122
Tennis elbowD013716EFO_1001896M77.122
Ankle injuriesD016512S93.411
Colorectal neoplasmsD01517911
Non-small-cell lung carcinomaD00228911
MelanomaD00854511
ArthritisD001168EFO_0005856M05-M14111
Open-angle glaucomaD005902EFO_0004190H40.111
PterygiumD011625H11.0111
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Plantar fasciitisD036981EFO_1001909M72.2112
Healthy volunteers/patients112
HypospadiasD007021EFO_0004209Q5411
VasoconstrictionD01466111
ProstatitisD011472EFO_0003830N4111
Amyotrophic lateral sclerosisD000690EFO_0000253G12.2111
Ataxia telangiectasiaD001260Orphanet_100G11.311
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
GoutD006073EFO_0004274M1011
Hypertrophic cicatrixD017439L91.011
CicatrixD002921HP_0100699L90.511
KeloidD007627EFO_0004212L91.011
Infant mortalityD00722611
Lichen planusD008010L4311
Hepatitis cD006526B19.211
VasculitisD014657EFO_0006803M3111
Autoimmune diseasesD001327EFO_0000540M30-M3611
Lichen sclerosus et atrophicusD018459L90.011
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameBETRIXABAN
INNbetrixaban
Description
Betrixaban is a secondary carboxamide obtained by formal condensation of the carboxy group of 4-(N,N-dimethylcarbamimidoyl)benzoic acid with the amino group of 2-amino-N-(5-chloropyridin-2-yl)-5-methoxybenzamide. A synthetic anticoagulant compound that targets activated factor Xa in the coagulation cascade. It has a role as an anticoagulant and an EC 3.4.21.6 (coagulation factor Xa) inhibitor. It is a member of guanidines, a member of benzamides, a secondary carboxamide, a monochloropyridine and a monomethoxybenzene.
Classification
Small molecule
Drug classantithrombotics, blood coagulation factor XA inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COc1ccc(NC(=O)c2ccc(C(=N)N(C)C)cc2)c(C(=O)Nc2ccc(Cl)cn2)c1
Identifiers
PDB
CAS-ID330942-05-7
RxCUI1927851
ChEMBL IDCHEMBL512351
ChEBI ID
PubChem CID10275777
DrugBankDB12364
UNII ID74RWP7W0J9 (ChemIDplus, GSRS)
Target
Agency Approved
F10
F10
Organism
Homo sapiens
Gene name
F10
Gene synonyms
NCBI Gene ID
Protein name
coagulation factor X
Protein synonyms
factor X, factor Xa, prothrombinase, Stuart factor, Stuart-Prower factor
Uniprot ID
Mouse ortholog
F10 (14058)
coagulation factor X (Q99L32)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 696 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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9,223 adverse events reported
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