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Benztropine
Cogentin (benztropine) is a small molecule pharmaceutical. Benztropine was first approved as Cogentin on 1982-01-01. It is used to treat drug-induced abnormalities and parkinson disease in the USA. It is known to target muscarinic acetylcholine receptor M2, muscarinic acetylcholine receptor M1, sodium-dependent dopamine transporter, and sodium-dependent neutral amino acid transporter B(0)AT1.
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Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
hereditary congenital and neonatal diseases and abnormalitiesD009358
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Benztropine mesylate
Tradename
Company
Number
Date
Products
COGENTINAkornN-012015 DISCN1982-01-01
1 products, RLD
COGENTINMerck KGaAN-009193 DISCN1982-01-01
3 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
benztropine mesylateANDA2023-06-13
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
drug-induced abnormalities—D000014—
parkinson diseaseEFO_0002508D010300G20
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N04: Anti-parkinson drugs
— N04A: Anticholinergic agents
— N04AC: Ethers of tropine or tropine derivatives, anticholinergic
— N04AC01: Benzatropine
HCPCS
Code
Description
J0515
Injection, benztropine mesylate, per 1 mg
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameBENZTROPINE
INNbenzatropine
Description
Benzatropine is tropane in which a hydrogen at position 3 is substituted by a diphenylmethoxy group (endo-isomer). An acetylcholine receptor antagonist, it is used (particularly as its methanesulphonate salt) in the treatment of Parkinson's disease, and to reduce parkinsonism and akathisia side effects of antipsychotic treatments. It has a role as an antiparkinson drug, a parasympatholytic, an antidyskinesia agent, a muscarinic antagonist and a oneirogen.
Classification
Small molecule
Drug classatropine derivatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccccc1)C2
Identifiers
PDB—
CAS-ID86-13-5
RxCUI—
ChEMBL IDCHEMBL1201203
ChEBI ID3048
PubChem CID1201549
DrugBankDB00245
UNII ID1NHL2J4X8K (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CHRM2
CHRM2
CHRM1
CHRM1
SLC6A3
SLC6A3
SLC6A19
SLC6A19
Organism
Homo sapiens
Gene name
CHRM2
Gene synonyms
NCBI Gene ID
1129
Protein name
muscarinic acetylcholine receptor M2
Protein synonyms
7TM receptor, acetylcholine receptor, muscarinic 2, muscarinic M2 receptor
Uniprot ID
Q9P1X9
Mouse ortholog
Chrm2 (243764)
muscarinic acetylcholine receptor M2 (Q9ERZ4)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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